TANAKA Keiji

J-GLOBAL         Last updated: Jan 10, 2019 at 11:08
 
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Name
TANAKA Keiji
E-mail
tanaka-kjigakuken.or.jp
URL
http://www.rinshoken.or.jp/
Affiliation
Tokyo Metropolitan Institute of Medical Science
Degree
ph. D. (The University of Tokushima)

Research Interests

 
 

Education

 
 
   
 
Graduate School of Medicine, The University of Tokushima
 
 
   
 
The University of Tokushima
 

Awards & Honors

 
2014
Nobel Forum Lecture at Karolinska Institute
 

Published Papers

 
Sugar-recognizing ubiquitin ligases - action mechanisms and physiology. In “E3 Ubiquitin Ligases: From Structure to Physiology”, hosted by VM. Bolanos-Garcia, J. Licchesi, H. Laman, F. Ikeda in Frontiers in Physiology
Yoshida, Y., Mizushima, T., and Tanaka, K.
section Integrative Physiology. in press      2019   [Refereed]
Methods to measure ubiquitin chain length and linkage
Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
Methods Enzymol. in press      2019   [Refereed]
TR-TUBE system: Method for detecting ubiquitination activity and identifying ubiquitinated substrates
Yoshida, Y., Saeki, Y., Tsuchiya, H., and Tanaka, K.
Methods Enzymol. in press      2019   [Refereed]
Takahama Y, Ohigashi I, Murata S, Tanaka K
Immunogenetics      Oct 2018   [Refereed]
Murata S, Takahama Y, Kasahara M, Tanaka K
Nature immunology   19(9) 923-931   Sep 2018   [Refereed]
Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S
Scientific reports   8(1) 10382   Jul 2018   [Refereed]
Uchida T, Sakashita Y, Kitahata K, Yamashita Y, Tomida C, Kimori Y, Komatsu A, Hirasaka K, Ohno A, Nakao R, Higashitani A, Higashibata A, Ishioka N, Shimazu T, Kobayashi T, Okumura Y, Choi I, Oarada M, Mills EM, Teshima-Kondo S, Takeda S, Tanaka E, Tanaka K, Sokabe M, Nikawa T
American journal of physiology. Cell physiology   314(6) C721-C731   Jun 2018   [Refereed]
Yamano, K., Wang, C., Sarraf, S.A., Münch, C., Kikuchi, R., Noda, N.N., Hizukuri, Y., Kanemaki, M.T., Harper, W., Tanaka, K., Matsuda, N., and Youle, R.J.
Elife 2018   7 pii: e31326   2018   [Refereed]
Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., and Tanaka, K.*, and Saeki, Y.* (*Correspondence)
Nat. Commun.   9 524   2018   [Refereed]
Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K.
Proc. Natl. Acad. Sci. USA   115 E1401-E1408   2018   [Refereed]
Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30
Sato, S., Okatsu1, K., Saeki, Y., Yamano, K., Matsuda, M., Kaiho, A., Yamagata, A., Goto-Ito, S., Ishikawa, M., Hashimoto, Y., Tanaka, K., and Fukai, S.
Nat. Struct. Mol. Biol.   24 911-919   2017   [Refereed]
A human PSMB11 variant affects thymoproteasome processing and CD8(+) T cell production
Ohigashi, I., Ohte, Y., Setoh, K., Nakase, H., Maekawa, A., Kiyonari, H., Hamazaki, Y., Sekai, M., Sudo, T., Tabara, Y., Sawai, H., Omae, Y., Yuliwulandari, R., Tanaka, Y., Mizokami, M., Inoue, H., Kasahara, M., Minato, N., Tokunaga, K., Tanaka, K., Matsuda, F., Murata, S., and Takahama, Y.
JCI Insight   pii: 93664   2017   [Refereed]
In vivo ubiquitin linkage-type analysis reveals that the Cdc48-Rad23/Dsk2 axis contributes to K48-linked chain specificity of the proteasome
Tsuchiya, H., Ohtake, F., Arai, N., Kaiho, A., Yasuda, S., Tanaka, K.*, and Saeki, Y.* (*Correspondence)
Mol. Cell   66 488-502   2017   [Refereed]
Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation
Kurimoto, E., Satoh, T., Ito, Y., Ishihara, E., Okamoto, K., Yagi-Utsumi, M., Tanaka, K., and Kato, K.
Protein Sci.   26 1080-1085   2017   [Refereed]
Foxn1-β5t transcriptional axis controls CD8+ T cell production in the thymus
Uddin, MM., Ohigashi, I., Motosugi, R., Nakayama, T., Sakata, M., Hamazaki, J., Nishito, Y., Rode, I., Tanaka, K., Takemoto, T., Murata, S., and Takahama, Y.
Nat. Commun.   8 14419   2017   [Refereed]
Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro
Matsuda, N., Kimura., M., Queliconi, B.B., Kojima, W., Mishima, M., Takagi, K., Koyano, F., Yamano, K., Mizushima, T., Ito, Y., and Tanaka, K.
Sci Rep.   7 12816   2017   [Refereed]
Inhibitory effects of local anesthetics on the proteasome and their biological actions
Bahrudin, U., Unno, M., Nishio, K., Kita, A., Li, P., Kato, M., Inoue, M., Tsujitani, S., Murakami, T., Sugiyama, R., Saeki, Y., Obara, Y., Tanaka, K., Yamaguchi, H., Sakane, I., Kawata, Y., Itoh, T., Ninomiya, H., Hisatome, I., and Morimoto, Y.
Sci. Rep.   7 5079   2017   [Refereed]
Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy
Yoshida, Y., Yasuda, S., Fujita, T., Hamasaki, M., Murakami, A., Kawawaki, J., Iwai, K., Saeki, Y., Yoshimori, T., Matsuda, M., and Tanaka, K
Proc. Natl. Acad. Sci. USA   114 8574-8579   2017   [Refereed]
The K48-K63 branched ubiquitin chain regulates NF-B signaling
Ohtake, F., Saeki, Y., Ishido, S., Kanno, J., and Tanaka, K.
Mol Cell   64 251-266   2016   [Refereed]
Biallelic variants in UBA5 link dysfunctional UFM1 ubiquitin-like modifier pathway to severe infantile-onset encephalopathy
Muona, M., Ishimura, R., Laari, A., Ichimura, Y., Linnankivi, T., Keski-Filppula, R., Herva, R., Rantala, H., Paetau, P., Pöyhönen, M., Obata, M., Uemura, T., Karhu, T., Bizen, N., Takebayashi, H., Anttonen, A-K., Tanaka, K., Palotie, A., Waguri, S., Lehesjoki, A-E., and Komatsu, M.
Am. J. Hum. Genet.   99 683-694   2016   [Refereed]
Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1mutants but not wild type DJ-1
Kojima, W., Kujuro, Y., Okatsu, K., Bruno, Q., Koyano, F., Kimura, M., Yamano, K., Tanaka, K., and Matsuda, N.
Genes Cells   21 772-788   2016   [Refereed]
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, M-S., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., and Komatsu, M.
Nat. Commun.   7 12030   2016   [Refereed]
Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells
Kincaid, E. Z., Murata, S., Tanaka, K., and Rock, K. L.
Nat. Immunol.   17 938-945   2016   [Refereed]
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation
Yamano, K., Matsuda, N., and Tanaka, K.
EMBO Rep.   17 300-316   2016   [Refereed]
Site-specific interaction mapping of phosphorylated ubiquitin to uncover parkin activation* *The Best of 2015
Yamano, K., Queliconi, B. B., Koyano, F., Saeki, Y., Hirokawa, T., Tanaka, K., and Matsuda, N.
J. Biol. Chem.   290 25199-25211   2015   [Refereed]
Measurement of proteasome activity in peripheral blood mononuclear cells as an indicator of susceptibility to bortezomib-induced severe neurological adverse events in patients with multiple myeloma
Cho, Y., Hori, M., Okoshi, Y., Fujisawa, F., Shinagawa, A., Kudo, D., Komeno, T., Yoshida, C., Katsura, Y., Ota, I., Shimizu, S., Kamoshita, M., Sasaki, K., Tanaka, K., Mukai, H.Y., and Kojima, H.
Acta Haematol.   134 25-31   2015   [Refereed]
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells
Sasaki, K., Takada, K., Ohte, Y., Kondo, H., Sorimachi, H., Tanaka, K., Takahama, Y., and Murata, M.
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells   6 7484   2015   [Refereed]
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells
Takada, K., van Laethem, F., Xing, Y., Akane, K., Suzuki, H., Murata, S., Tanaka, K., Jameson, S.C., Singer, A., and Takahama, Y.
Nat. Immunol.   16 1069-1076   2015   [Refereed]
Phosphorylated ubiquitin chain is the genuine Parkin receptor
Okatsu, K., Koyano, F., Kimura, M., Kosako, H., Saeki, Y., Tanaka, K.*, and Matsuda, N.* (*cocorespondences)
J. Cell Biol.   209 111-128   2015   [Refereed]
A comprehensive method for detecting ubiquitinated substrates using TR-TUBE
Yoshida, Y., Yasushi Saeki, Y., Murakami, A., Kawawaki, J., Tsuchiya, H., Yoshihara, H., Shindo, M., and Tanaka, K.
Proc. Natl. Acad. Sci. USA   112 4630-4635   2015   [Refereed]
Unconventional PINK1 localization mechanism to the outer membrane of depolarized mitochondria drives Parkin recruitment
Okatsu, K., Kimura, M., Oka, T., Tanaka, K., and Matsuda, N.
J. Cell Sci.   128 964-978   2015   [Refereed]
The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates
Morimoto, D., Walinda, E., Fukada, H., Sou, Y.S., Kageyama, S., Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., and Shirakawa M.
Nat. Commun.   6 6116   2015   [Refereed]
Mutations in the deubiquitinase gene USP8 cause Cushing’s disease
Reincke, M., Sbiera, S., Hayakawa, A., Theodoropoulou, M., Osswald, A., Beuschlein, F., Meitinger, T., Mizuno-Yamasaki, E., Kawaguchi, K., Saeki, Y., Tanaka, K., Wieland, T., Graf, E., Saeger, W., Ronchi, C.L., Allolio, B., Buchfelder, M., Strom, T.M., Fassnacht, M., and Komada M.
Nat. Genet.   47 31-38   2015   [Refereed]
Ubiquitin acetylation inhibits polyubiquitin chain elongation
Ohtake, F., Saeki, Y., Sakamoto, K., Ohtake, K., Nishikawa, H., Tsuchiya, H., Ohta, T., Tanaka, K., and Kanno, J.
EMBO Rep.   16 192-201   2015   [Refereed]
Tagged tags engage disposal
Matsuda, N. and Tanaka, K.
Nature (News and Views)   524 294-295   2015   [Refereed]
Modification of ASC1 by UFM1 is crucial for ER transactivation and breast cancer development
Yoo, H. M., Kang, S. H., Kim, J. Y., Lee, S. W., Seong, M. W., Ka, S. H., Sou, Y-S., Komatsu, M., Tanaka, K., Lee, S. T., Noh, D. Y., Baek, S. H., Jeon, Y. J., and Chung, C. H.
Mol. Cell   56 261-274   2014   [Refereed]
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway
Kageyama, S., Sou, Y. S., Uemura, T., Kametaka, S., Saito, T., Ishimura, R., Kouno, T, Bedford, L., Mayer, R. J., Lee, M. S., Yamamoto, M., Waguri, S., Tanaka, K., and Komatsu, M.
J. Biol. Chem.   289 24944-24955   2014   [Refereed]
Ubiquitin is phosphorylated by PINK1 to activate parkin
Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E.A., Trempe, J. F., Saeki, Y., Tanaka, K.*, and Matsuda, N.* (*Correspondence)
Nature   510 162-166   2014   [Refereed]
Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome
Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
Nat. Commun.   5 3396   2014   [Refereed]
Structural basis for proteasome formation controlled by an assembly chaperone Nas2
Satoh, T., Saeki, Y., Hiromoto, T., Wang, Y-H., Uekusa, Y., Yagi, H., Yoshihara, H., Yagi-Utsumi, M., Mizushima, T., Tanaka, K., and Kato, K.
Structure   22 731-743   2014   [Refereed]
Ubiquitin chain elongation: An intriguing strategy
Iwai, K. and Tanaka, K.
Mol Cell (preview)   56 189-191   2014   [Refereed]
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K. *, Yamamoto, M., * and Komatsu, K. * (*cocorespondences)
Mol Cell   51 618-631   2013   [Refereed]
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment
Okatsu, K., Uno, M., Koyano, F., Go, E., Kimura, M., Oka, T., Tanaka, K., and Matsuda, N.
J. Biol. Chem.   288 36372-36384   2013   [Refereed]
Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells
Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
Proc Natl Acad Sci USA   110 9885-9890   2013   [Refereed]
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons
Koyano, F., Okatsu, K., Ishigaki, S., Fujioka, Y., Kimura, M., Sobue, G., Tanaka, K.* and Matsuda, N* (*cocorespondences)
Genes Cells   18 672-681   2013   [Refereed]
Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae
Tsuchiya, H., Arai, N., Tanaka, K.,* and Saeki, Y.* (*cocorespondences)
Biochem Biophys Res Commun   436 372-376   2013   [Refereed]
The parallel reaction monitoring method contributes to highly sensitive polyubiquitin chain quantification
Tsuchiya, H., Tanaka, K., * and Saeki, Y.* (*cocorespondences)
Biochem Biophys Res Commun   436 223-229   2013   [Refereed]
Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation
Iguchi, M. ¶, Kujuro, Y. ¶, Okatsu, K. ¶, Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K.*, and Matsuda, N. (¶These authors equally contributed to this work)
J Biol Chem   288 22019-22032   2013   [Refereed]
Akahane, T., Sahara, K., Yashiroda, H., Tanaka, K., and Murata, S.
Nat Commun.   4 2234   2013   [Refereed]
The proteasome: molecular machinery and pathophysiological roles
Tanaka, K., Mizushima, T., and Saeki, Y.
Biol Chem.   393 217-234   2012   [Refereed]
Structural basis for specific recognition of Rpt1, an ATPase subunit of the 26S proteasome, by the proteasome-dedicated chaperone Hsm3
Takagi, K., Kim, S., Yukii, H., Ueno, M., Morishita , R., Endo, Y., Kato, K., Tanaka, K., Saeki, Y. *, and Mizushima, Y. * *Correspondences
J Biol Chem.** **The Best of 2012   287 12172-12182   2012   [Refereed]
Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy
Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Förster F, and Baumeister W
Proc Natl Acad Sci USA   109 1479-1484   2012   [Refereed]
Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities
Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, and Kasahara M.
Am. J. Pathol.   180 963-972   2012   [Refereed]
Proteasomal degradation resolves competition between cell polarization and cellular wound healing
Kono, K., Saeki, Y., Yoshida, S., Tanaka, K., and Pellman, D.
Cell   150 151-164   2012   [Refereed]
Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, and Matsuda N.
Nat Commun.   3 1016   2012   [Refereed]
Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase
Okatsu, K., Iemura, S., Koyano, F., Go, E., Kimura, M., Natsume, T., Tanaka, K., and Matsuda, N.
Biochem Biophys Res Commun.   428 197-202   2012   [Refereed]
Thymic nurse cells do not nurse most T cells but support TCR revision in cortical thymocytes
Nakagawa, Y., Ohigashi, I., Nitta, T., Tanaka, K., Murata, S., Sakata, M., and Takahama, Y.
Proc Natl Acad Sci USA   109 20572-20577   2012   [Refereed]
β5t-containing thymoproteasome: thymic cortical epithelial cell-specific expression and role in positive selection of CD8+ T cells
48. Takahama, Y., Takada, K., Murata, S., and Tanaka, K.
Curr. Opini. Immunol.   24 92-98   2012   [Refereed]
Assembly and function of the proteasome
Saeki, Y and Tanaka, K.
Methods Mol Biol   832 315-337   2012   [Refereed]
A mutation in an immunoproteasome subunit causes autoinflammation and lipodystrophy in humans
Kitamura, A., Maekawa, Y., Uehara, H., Izumi, K., Kawachi, I., Nishizawa, M., Toyoshima, Y., Takahashi, H., Standley, D.M., Tanaka, K., Hamazaki, J., Murata, S., Obara, K., Toyoshima, I., and Yasutomo, K.
J. Clin. Invest.   121 4150-4160   2011   [Refereed]
Assembly defect due to a PSMB8 mutation reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome
Arima, K., Kinoshita, A., Mishima, H., Kanazawa, N., Kaneko, T., Mizushima, T., Ichinose, K., Nakamura, H., Tsujino, A., Kawakami, A., Matsunaka, M., Kasagi, S., Kawano, S., Kumagai, S., Ohmura, K., Mimori, T., Hirano, M., Ueno, S., Tanaka, K., Tanaka, M., Toyoshima, I., Sugino, H., Yamakawa, A., Tanaka, K., Niikawa, N., Furukawa, F., Murata, S., Eguchi, K., Ida, H., and Yoshiura, K
Proc. Natl. Acad. Sci. USA   108 14914-14919   2011   [Refereed]
The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle
Sakata, E., Stengel, F., Fukunaga, K., Zhou, M., Saeki, Y., Förster, F., Baumeister, W.*, Tanaka, K.*, and Robinson, CV.**correspondences
Mol. Cell   42 637-649   2011   [Refereed]
Role of persistent activation of Nrf2 through p62 in hepatocarcinogenesis
Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Andoh, J., Iwadate, M., Yamamoto, M., Lee. M-S., Tanaka, K., and Komatsu, K.
J. Cell. Biol.   193 275-284   2011   [Refereed]
Autophagy-deficient mice develop multiple liver tumors
Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino O., Tanaka, K., and Mizushima, N.
Genes Dev.   25 795-800   2011   [Refereed]
Ontogeny of thymic cortical epithelial cells expressing thymoproteasome subunit β5t
Ripen, AM., Nitta, T., Murata, S., Tanaka, K., and Takahama, Y.
Eur. J. Immunol.   41 1278-1287   2011   [Refereed]
Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex
Tokunaga, F., Nakagawa, T., Nakahara1, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., and Iwai, I.
Nature   471 633-636   2011   [Refereed]
Tatsumi, K., Yamamoto-Mukai, H., Shimizu, R., Waguri , S., Sou, Y-S., Sakamoto, A., Taya, C., Shitara, H., Hara , T., Chung, C.H., Tanana, K., Yamamoto, M., and Komatsu, M.
Nat. Commun.   2 181   2011   [Refereed]
Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiae
Fukunaga, K., Kudo, T., Toh-e, A., Tanaka, K., and Saeki, Y.
Biochem. Biophys. Res. Commun.   396 1048-1053   2010   [Refereed]
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., Tanaka, K., and Matsuda, N.
Genes Cells   15 887-900   2010   [Refereed]
PINK1 stabilized by depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, CA Sou, Y., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., and Tanaka, K.
J Cell Biol.   189 211-221   2010   [Refereed]
Crystal structure of yeast Rpn14, a chaperone of the 19S regulatory particles of the proteasome
Kim, S.*, Saeki, S.*, Fukunaga, K., Suzuki, A., Takagi, K., Yamane, T., Tanaka, K., Mizushima, T., and Kato, K.
J. Biol. Chem.   285 15159-15166   2010   [Refereed]
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y-S., Ueno, I., Sakamoto, A., Tong. K. I., Kim, M., Nishito Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., and Yamamoto, M
Nat. Cell Biol.   12 213-223   2010   [Refereed]
Novel type of E3 ligase for Ufm1-conjugating system
Tatsumi, K., Sou, Y., Tada, N., Nakamura, E., Iemura, S., Natsume, T., Kang, SW., Chung, CH., Kasahara, M., Kominami, E., Tanaka, K., and Komatsu, M
J. Biol. Chem.   285 5417-5427   2010   [Refereed]
Thymoproteasome shapes immunocompetent repertoire of CD8 T cells
Nitta, T., Murata, S., Sasaki, K., Fujii, H., Ripen, A. M., Ishimaru, N., Koyasu, S., Tanaka, K., and Takahama, Y.
Immunity   32 29-40   2010   [Refereed]
PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and importance of latent 20S proteasomes in maintaining cellular homeostasis
Sasaki, K., Hamazaki, J., Koike, M., Hirano, Y., Komatsu, M., Uchiyama, Y., Tanaka, K., and Murata, M.
Mol Cell. Biol.   30 3864-3874   2010   [Refereed]
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t
Florea, B.I., Verdoes, M., Li ,N., van der Linden, W.A., Geurink, P.P., van den Elst, H., Hofmann, T., de Ru, A., van Veelen, P.A., Tanaka, K., Sasaki, K., Murata, S., den Dulk, H., Brouwer, J., Ossendorp, F.A., Kisselev, A.F., and Overkleeft, H.S.
Chem Biol.   17 795-801   2010   [Refereed]
Ubiquitin accumulation in autophagy-deficinet mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection
Riley, B.E., Kaiser, S.E., Shaler, T.A., Ng, A.C.Y., Hara, T., Hipp, M.S., Lage, K., Xavier, R. J., Ryu, K-Y., Taguchi, K., Yamamoto,M., Tanaka, K., Mizushima, N., Komatsu, M., and Kopito, R.R.
J. Cell Biol.   191 537-552   2010   [Refereed]
Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson’s disease?
Matsuda, N. and Tanaka, K.
J Alzheimer’s Dis.   19 1-9   2010   [Refereed]
Lectin-like ERAD players in ER and cytosol
Yoshida, Y. and Tanaka, K.
Biochem. Biophys. Acta   1800 172-180   2010   [Refereed]
Role of thymic cortex-specific self-peptides in positive selection of T cells
Takahama, Y., Nitta, T., Ripen, A. M., Nitta, S., Murata, M., and Tanaka, K.
Semin. Immunol.   22 287-293   2010   [Refereed]
Uncovering the roles of PINK1 and parkin in mitophagy
Matsuda, N. and Tanaka, K.
Autophagy   6 952-954   2010   [Refereed]
Linear ubiquitination of NEMO triggers NF-B activation
Tokunaga, T., Sakata, S., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Murata, S., Yamaoka, S., Takao, T., Tanaka, K., and Iwai K.
Nat. Cell Biol.   11 123-132   2009   [Refereed]
Genetic evidence linking age-dependent attenuation of the 26S proteasome with aging process
Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K., and Miura. M.
Mol. Cell. Biol.   29 1095-1106   2009   [Refereed]
Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome
Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A., and Tanaka, K.
EMBO J.  *Science 323 (2009)の“Editors’ Choice”で紹介   28 359-371   2009   [Refereed]
An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis
Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K.
Cell   137 549-559   2009   [Refereed]
Exclusive expression of proteasome subunit 5t in the human thymic cortex
Tomaru, U., Ishizu, A., Murata, S., Miyakate, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K., and Kasahara, M.
Blood   113 5186-5189   2009   [Refereed]
Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle
Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., and Tanaka, K.
Cell   137 900-913   2009   [Refereed]
Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperone
Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., and Murata, S.
Cell   137 914-925   2009   [Refereed]
The 20S proteasome as an assembly platform for the 19S regulatory complex
Hendil, K. B. Kriegenburg, F., Tanaka, K., Murata, S., Lauridsen, A-M. B, Anders H. Johnsen, and Hartmann-Petersen, R.
J. Mol. Biol.   394 320-328   2009   [Refereed]
Molecular mechanisms of proteasome assembly
Murata, S., Yashiroda, H., and Tanaka, K.
Nat. Rev. Mol. Cell. Biol.   10 104-115   2009   [Refereed]
The proteasome: Overview of structure and functions
Tanaka, K.
Proc. Jpn. Acad. Ser. B Phys Biol Sci   85 12-36   2009   [Refereed]
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases
Yue, Z., Friedman, L., Komatsu, M., and Tanaka, K.
Biochem. Biophys. Acta   1793 1793-1507   2009   [Refereed]
The proteasome’s crown for destruction
Sakata, E., Saeki, Y., and Tanaka, K.
Mol. Cell (preview)   34 519-520   2009   [Refereed]
Sou Yu-shin, Waguri Satoshi, Iwata Jun-ichi, Ueno Takashi, Fujimura Tsutomu, Hara Taichi, Sawada Naoki, Yamada Akane, Mizushima Noboru, Uchiyama Yasuo, Kominami Eiki, Tanaka Keiji, Komatsu Masaaki
MOLECULAR BIOLOGY OF THE CELL   19(11) 4762-4775   Nov 2008   [Refereed]
Saitoh Tatsuya, Fujita Naonobu, Jang Myoung Ho, Uematsu Satoshi, Yang Bo-Gie, Satoh Takashi, Omori Hiroko, Noda Takeshi, Yamamoto Naoki, Komatsu Masaaki, Tanaka Keiji, Kawai Taro, Tsujimura Tohru, Takeuchi Osamu, Yoshimori Tamotsu, Akira Shizuo
NATURE   456(7219) 264-268   Nov 2008   [Refereed]
Ebato Chie, Uchida Toyoyoshi, Arakawa Masayuki, Komatsu Masaaki, Ueno Takashi, Komiya Koji, Azuma Kosuke, Hirose Takahisa, Tanaka Keiji, Kominami Eiki, Kawamori Ryuzo, Fujitani Yoshio, Watada Hirotaka
CELL METABOLISM   8(4) 325-332   Oct 2008   [Refereed]
Yamano Taketoshi, Mizukami Shusaku, Murata Shigeo, Chiba Tomoki, Tanaka Keiji, Udono Heiichiro
JOURNAL OF BIOLOGICAL CHEMISTRY   283(42) 28060-28065   Oct 2008   [Refereed]
Yoshida Yuko, Takeda Shinhiro, Akada Shinji, Hongo Takashi, Tanaka Keiji, Sakamoto Atsuhiro
JOURNAL OF ANESTHESIA   22(3) 201-206   Aug 2008   [Refereed]
Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes
Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama, T., Hayashi, H., Kishimoto, T., Kasahara, M., Kurimoto, E., Sakata, E., Suzuki, A., Hirano, Y., Murata , S., Kato, K., Yamane, T., and Tanaka, K.
Nat. Struct. Mol. Biol.   15 228-236   2008   [Refereed]

Misc

 
佐藤慎吉, 佐伯泰, 田中啓二, 稲田利文
日本薬学会東北支部大会講演要旨集   57th 56   Oct 2018
池内健, 杉山誉人, 松尾芳隆, 佐伯泰, 田中啓二, 稲田利文
日本RNA学会年会要旨集   20th 80   Jul 2018
板橋直樹, 杉本良之, 藤村康, 田中啓二, 荻田省一
電子情報通信学会技術研究報告   118(62(LQE2018 10-19)) 33‐36   May 2018
板橋直樹, 杉本良之, 藤村康, 田中啓二, 荻田省一
電子情報通信学会大会講演論文集(CD-ROM)   2018 ROMBUNNO.C‐4‐5   Mar 2018
DJ-1の局在解析から見出す非典型的ミトコンドリア局在化シグナル
小島 和華, 山野 晃史, 木村 まゆみ, Bruno Queliconi, 田中 啓二, 松田 憲之
生命科学系学会合同年次大会   2017年度 [1P-0324]   Dec 2017

Research Grants & Projects

 
Mechanism of intracellular protein degradation mediated by ubiquitin and proteasomes