WATABE Kazuhiko

J-GLOBAL         Last updated: Aug 8, 2019 at 13:40
 
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Name
WATABE Kazuhiko
Affiliation
Kyorin University
Section
Faculty of Health Sciences
Job title
Laboratory Director
Degree
MD. PhD(Niigata University)
ORCID ID
0000-0002-0245-3834

Research Areas

 
 

Academic & Professional Experience

 
Apr 2016
 - 
Today
Professor, Department of Medical Technology, Kyorin University Faculty of Health Sciences
 
Apr 2011
 - 
Mar 2016
Project Leader, Tokyo Metropolitan Institute of Medical Science
 
Jan 1997
 - 
Mar 2011
Laboratory Director, Dept. of Neuropathology, Tokyo Metropolitan Institute for Neuroscience
 
Oct 1991
 - 
Dec 1996
Assistant Professor, Division of Neuropathology, Jikei University School of Medicine
 
Oct 1989
 - 
Sep 1991
Instructor, 2nd Dept. of Inernal Medicine, Jikei University School of Medicine
 

Education

 
Apr 1981
 - 
Mar 1985
Experimental Neuropathology, Graduate School of Medicine, Niigata University
 
Apr 1975
 - 
Mar 1981
School of Medicine, Niigata University
 

Published Papers

 
Niimi N, Yako H, Takaku S, Kato H, Matsumoto T, Nishito Y, Watabe K, Ogasawara S, Mizukami H, Yagihashi S, Chung SK, Sango K
Journal of neurochemistry   144(6) 710-722   Mar 2018   [Refereed]
SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
Moriwaki Y, Ohno Y, Ishii T, Takamura Y, Kita Y, Watabe K, Sango K, Misawa H.
PLoS One   13(6) e0199829   Jun 2018   [Refereed]
Yanagisawa H, Ishii T, Endo K, Kawakami E, Nagao K, Miyashita T, Akiyama K, Watabe K, Komatsu M, Yamamoto D, Eto Y
Scientific reports   7(1) 15944   Nov 2017   [Refereed]
Ishii T, Kawakami E, Endo K, Misawa H, Watabe K
Neuropathology : official journal of the Japanese Society of Neuropathology   37(5) 475-481   Oct 2017   [Refereed]
Ishii T, Kawakami E, Endo K, Misawa H, Watabe K
PloS one   12(6) e0179375   2017   [Refereed]

Misc

 
A case of renal amyoidosis associated with hepatic adenoma: the pathogenetic role of tumor necrosis factor-alpha.
Nephron 75(3) (1997) 350-353   
Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons.
Neuro Report 11 (2000) 1857-1860.   
Adenovirus-mediated transduction with human glial cell line-derived neurotrophic fator gene prevents 1-methyl-4-phenyl-1, 2,3,6- tetrahydrophridine-induced dopmaine depletion in striatum of mouse brain,
Biochem Biophys Res Commun 238(2) (1997) 569-573   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2009 - Mar 2012    Investigator(s): Kazuhiko WATABE
Impairment of proteolytic machineries has been recognized to participate in motoneuron degeneration in ALS. Furthermore, recent identifications of disease-associated genes that include TDP-43 and FUS have led to open a new era in ALS research. We ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2007    Investigator(s): Kazuhiko WATABE
Neurogenesis occurs throughout life in two specific regions of the adult mammalian brain; the subventricular zone of the lateral ventricle and the subgranular zone of the hippocampal dentate gyrus. After injury and pathological stimulations, adult...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2002 - 2004    Investigator(s): Kazuhiko WATANABE
We have utilized adult rat peripheral nerve avulsion models to evaluate the effects of neuroprotective molecules on motoneuron degeneration. The right facial nerves of adult Fischer 344 male rats were avulsed and adenoviral vectors encoding glial ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2001    Investigator(s): Kazuhiko WATANABE
We examined neuroprotective effects of recombinant adenoviral vectors encoding glial cell linederived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT 1), transforming gr...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Kazuhiko WATABE
Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect cranial and spinal motoneurons, that suggests potential uses of GDNF in the treatment of spinal cord injury and motor neuron diseases. We examined neuroprotective effect ...