藤原和子 (Kazuko Fujiwara) - マイポータル - researchmap

基本情報

所属: 徳島大学疾患酵素学研究センター酵素分子生理学部門助教授

学位: 医学博士(徳島大学)

J-GLOBAL ID: 200901036198986740
researchmap会員ID: 0000031971

外部リンク: http://mms1.ier.tokushima-u.ac.jp/bunshi-seiri/bunshi-seiri.html

研究キーワード

4

研究分野

1

ライフサイエンス / 医化学 /

経歴

4

学歴

2

- 1968年

京都大学, 薬学部, 製薬化学科
京都大学

MISC

31

Crystal structure of bovine lipoyltransferase in complex with lipoyl-AMP

Kazuko Fujiwara, Harumi Hosaka, Makoto Matsuda, Kazuko Okamura-Ikeda, Yutaro Motokawa, Mamoru Suzuki, Atsushi Nakagawa, Hisaaki Taniguchi

JOURNAL OF MOLECULAR BIOLOGY 371(1) 222-234 2007年8月
Crystal structure of lipoate-protein ligase a from Escherichia coli - Determination of the lipoic acid-binding site

K Fujiwara, S Toma, K Okamura-Ikeda, Y Motokawa, A Nakagawa, H Taniguchi

JOURNAL OF BIOLOGICAL CHEMISTRY 280(39) 33645-33651 2005年9月
Crystal Structure of Human T-protein of Glycine Cleavage System at 2.0 Å Resolution and its Implication for Understanding Non-ketotic Hyperglycinemia

J. Mol. Biol. 351 (5), 1146–1159 (2005) J. Mol. Biol. 351 (5), 1146–1159 2005年
Glycine cleavage system in neurogenic regions

Eur. J. Neurosci. 19 (9) 2365–2370 2004年
Probing the H-protein-induced conformational change and the function of the N-terminal region of Escherichia coli T-protein of the glycine cleavage system by limited proteolysis

K Okamura-Ikeda, N Kameoka, K Fujiwara, Y Motokawa

JOURNAL OF BIOLOGICAL CHEMISTRY 278(12) 10067-10072 2003年3月
リポ酸を補欠分子族として持つタンパク質のリポイル化

生化学 75(1) 17-26 2003年
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver

J. Bio. Chem. 276, 28819-28823 2001年
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver

J. Bio. Chem. 276, 28819-28823 2001年
Identification of the folate brinding sites on the Escherichia coli T-protein of the glycine cleavage system

J. Biol. Chem. 274, 17471-17477 1999年
The amino-terminal region of the Escherichia coli T-protein of the glycine clemage system is essential for proper association with H-protein.

Eur. J. Biochem. 264, 446-452 1999年
Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene

Eur. J. Biochem. 260, 761-767 1999年
Identification of the folate brinding sites on the Escherichia coli T-protein of the glycine cleavage system

J. Biol. Chem. 274, 17471-17477 1999年
The amino-terminal region of the Escherichia coli T-protein of the glycine clemage system is essential for proper association with H-protein.

Eur. J. Biochem. 264, 446-452 1999年
Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene

Eur. J. Biochem. 260, 761-767 1999年
Cloning and expression of a cDNA encoding bovine lipoyltransferase

Kazuko Fujiwara, Kazuko Okamura-Ikeda, Yutaro Motokawa

Journal of Biological Chemistry 272(51) 31974-31978 1997年12月19日
Lipoate addition to acyltransferases of alpha-keto acid dehydrogenase complexes and H-protein of glycine cleavage system.

Methods Enzymol. 279, 184-193 1997年
Synthesis and characterization of selenolipoylated H-protein of the glycine cleavage system.

J. Biol. Chem. 272, 19880-19883 1997年
Lipoate addition to acyltransferases of alpha-keto acid dehydrogenase complexes and H-protein of glycine cleavage system.

Methods Enzymol. 279, 184-193 1997年
Synthesis and characterization of selenolipoylated H-protein of the glycine cleavage system.

J. Biol. Chem. 272, 19880-19883 1997年
Lipoylation of acyltransferase components of alpha-ketoacid dehydrogenase complexes.

J. Biol. Chem. 271, 12932-12936 1996年

もっとみる

書籍等出版物

6

Lipoate-Protein Ligase A: Structure and Function in Lipoic acid: Energy production, Antioxidant Activity and Health Effects

CRC Press, Taylor & Francis Group. Edited by Mulchand S. Patel and Lester Packer 2008年
Activation and transfer of lipoic acid in protein lipoylation in mammals

Thiamine: Catalytic Mechanisms in Normal and Disease States (Ed. by Jordan, F., and Patel, M. S.) 2004年
Lipoylation of E2 component in Alpha-Keto Acid Dehydrogenase Complexes

Birkhaeuser Verlag 1996年
Lipoylation of E2 component in Alpha-Keto Acid Dehydrogenase Complexes

Birkhaeuser Verlag 1996年
Role of lipoic acid in the glycine cleavage system and lipoylation of H-protein(Biothiols in Health and Disease

Marcel Dekker, Inc. 1995年
Role of lipoic acid in the glycine cleavage system and lipoylation of H-protein(Biothiols in Health and Disease

Marcel Dekker, Inc. 1995年

所属学協会

2

共同研究・競争的資金等の研究課題

4

タンパク質相互作用の研究

科学研究費補助金 2002年
Study on protein interaction

Grant-in-Aid for Scientific Research 2002年
蛋白のリポイル化の機構

科学研究費補助金 1991年
Mechanism of protein lipoylation

Grant-in-Aid for Scientific Research 1991年