藤田尚志 (Takashi Fujita) - マイポータル

基本情報

所属: 京都大学ウイルス研究所遺伝子動態調節研究部門分子遺伝学研究分野教授

学位: 理学博士

J-GLOBAL ID: 200901038018322086
researchmap会員ID: 0000032163

外部リンク: http://www.rinshoken.or.jp/

研究キーワード

研究分野

ライフサイエンス / 免疫学 /

経歴

もっとみる

学歴

受賞

論文

228

Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.

藤田尚志

PLOS ONE doi: 10.1371/journal.pone.0212 2019年2月査読有り
Type III Interferon Restriction by Porcine Epidemic Diarrhea Virus and the Role of Viral Protein nsp1 in IRF1 Signaling.

藤田尚志

J. Virol. 92(4) doi:10.1128/JVI.01677-17 2018年11月査読有り
Interferon stimulation creates chromatin marks and establishes transcriptional memory.

藤田尚志

PNAS doi.org/10.1073/pnas.172093011 2018年9月査読有り
Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction.

藤田尚志

PLOS ONE doi: 10.1371/journal.pone.0197 2018年5月査読有り
RLRs and TLRs Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in an SFTSV Infection Mouse Model.

藤田尚志

J Virol doi: 10.1128/JVI.02246-17 2018年4月査読有り
Structure-dependent antiviral activity of catechol derivatives in pyroligneous acid against the encephalomycarditis virus.

藤田尚志

RSC Adv. 8 35888-35896 2018年査読有り
Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes.

藤田尚志

Virology 525 48-61 2018年査読有り
A Plant-Derived Nucleic Acid Reconciles Type I IFN and a Pyroptotic-like Event in Immunity against Respiratory Viruses.

藤田尚志

J Immunol 199(7) 2460-2474 2017年8月査読有り
Establishment of a human hepatocellular cell line capable of maintaining long-term replication of hepatitis B virus

Wan-Ling Yao, Sotaro Ikeda, Yuta Tsukamoto, Keiko Shindo, Yukie Otakaki, Mian Qin, Yoshikazu Iwasawa, Fumihiko Takeuchi, Yuki Kaname, Yu-Chi Chou …

INTERNATIONAL IMMUNOLOGY 29(3) 109-120 2017年3月査読有り
Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.

藤田尚志

PLoS Pathog doi: 10.1371/journal.ppat.1005 2016年査読有り
Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in COPD Epithelium.

藤田尚志

Am J Respir Cell Mol Biol 55(1) 117-127 2016年査読有り
RIG-I-like receptors and autoimmune diseases.

藤田尚志

Curr Opin Immunol 37 40-45 2015年10月査読有り招待有り
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.

藤田尚志

Sci Signal 8(388) 2015年8月査読有り
Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

藤田尚志

J Exp Med. 212(9) 1371-1379 2015年8月査読有り
Influence of Genes Suppressing Interferon Effects in Peripheral Blood Mononuclear Cells during Triple Antiviral Therapy for Chronic Hepatitis C

Sayuki Iijima, Kentaro Matsuura, Tsunamasa Watanabe, Koji Onomoto, Takashi Fujita, Kyoko Ito, Etsuko Iio, Tomokatsu Miyaki, Kei Fujiwara, Noboru Shinkai …

PLOS ONE 10(2) 2015年2月査読有り
Viral RNA detection by RIG-I-like receptors.

藤田尚志

Curr Opin Immunol 32 48-53 2015年1月査読有り招待有り
Autoimmunity caused by constitutive activation of cytoplasmic viral RNA sensors

Hiroki Kato, Takashi Fujita

CYTOKINE & GROWTH FACTOR REVIEWS 25(6) 739-743 2014年12月査読有り
A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection

Ryo Narita, Kiyohiro Takahasi, Etsu Murakami, Emi Hirano, Seiji P. Yamamoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita

PLOS PATHOGENS 10(10) 2014年10月査読有り
Antiviral innate immunity and stress granule responses

Koji Onomoto, Mitsutoshi Yoneyama, Gabriel Fung, Hiroki Kato, Takashi Fujita

TRENDS IN IMMUNOLOGY 35(9) 420-428 2014年9月査読有り招待有り
Sensing viral invasion by RIG-I like receptors

Ji-Seung Yoo, Hiroki Katol, Takashi Fujita

CURRENT OPINION IN MICROBIOLOGY 20 131-138 2014年8月査読有り

もっとみる

MISC

Antiviral innate immunity in health and disease.

藤田尚志

NIH-Japan-JSPS Symposium-Highlights from the frontier of biomedical science from NIH and Japan 2014年10月招待有り
Dysregulation of MDA5-dependent signaling causes autoimmune disorder.

藤田尚志

NHRI/IBMS Joint International Conference on Inflammation & Disease 2014年10月招待有り
Regulation of antiviral innate immunity by RIG-I-Like Receptors

藤田尚志

EMBO Workshop Human RNA Viruses, Istanbul, Turkey 2014年10月招待有り
A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection

Ryo Narita, Kiyohiro Takahasi, Etsu Murakami, Emi Hirano, Seiji P. Yamamoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita

PLOS PATHOGENS 10(10) 2014年10月
Innate Immune Responses Against Hepatitis B Virus in ES2.

藤田尚志

International Meeting on Molecular Mechanism of Hepatitis B Viruses, UCLA, USA 2014年9月
Blocking innate immune responses enhanced HBV replication.

藤田尚志

2014 TASL-Japan Hepatitis B Workshop 2014年4月
Regulation of antiviral innate immunity by RIG-I-like receptors.

藤田尚志

The NF-κB system in health and disease, Keystone Symposia 2014年2月招待有り
Size-dependent sensing of viral RNA during antiviral responses.

Fujita T

Positive strand RNA Viruses Keystone Symposia 2013年4月23日
Functional role of Pumilio in IFN induction mediated by RLRs.

藤田尚志

The 2nd Meeting on RNA and Biofunctions-Asia Study "RNA Biofunctions and Viruses" 2013年1月
Detection of cytoplasmic non-self RNA and activation of antiviral innate immunity.

Fujita T

International Endotoxin and Innate Immunity Society Meeting 2012, 2012年10月23日
Autoimmunity and nephritis caused by MDA5 mutation depend on IPS-1.

藤田尚志

The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine, 2012年10月
Inhibition of virus-induced interferon gene activation through modulation of cytoplasmic stress granules by a viral protease.

藤田尚志

The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine 2012年10月査読有り
Cytoplasmic sensing of viral RNA by RIG-I-like receptors.

Fujita T

Non-self RNA sensing in virus infected cells and activation of antiviral immunity. Le Treilles, France 2012年9月11日
The anti-tumor agent DMXAA induces IFN-β response via STING. 9.

藤田尚志

The 11th Awaji International Forum on Infection and Immunity 2012年9月
Mechanism and Physiological Role of Granules Formed by Viral Nucleocapsid Protein.

藤田尚志

The 11th Awaji International Forum on Infection and Immunity 2012年9月
Sensing viral RNA in cytoplasm and activation of the interferon system

Fujita T

ICGEB Workshop "Human RNA Viruses" Buenos Aires 2012年4月3日
Antiviral Innate Immunity: Control of Interferon Production.

Fujita T

NF-kappaB Signaling and Biology: From Bench to Bedside, Keystone Symposia 2012年3月12日
Sensing Viral RNA in Cytoplasm and Activation of Antiviral Innate Immunity.

Fujita T

Innate Immunity: Sensing the Microbes and Damage Signals, Keystone Symposia 2012年3月5日
Recognition of Green Pepper dsRNA by Viral RNA Sensor.

藤田尚志

10th NTU-KU Joint Symposium on Molecular and Cell Biology 2012年1月査読有り
6 regulates innate immunity by mediating of PKR-RIG-I axis signaling pathway.

Yoo J-S, Kato H, Nagamine Y, Fujita T

2012 6.21 第77 回日本インターフェロン・サイトカイン学会学術集会神戸 2012年査読有り

もっとみる

書籍等出版物

Nucleic Acid Sensors and Antiviral Immunity

藤田尚志 (担当:共編者(共編著者))

Landes Bioscience 2013年
Antiviral MicroRNA

藤田尚志 (担当:共著)

Springer 2013年

所属学協会

共同研究・競争的資金等の研究課題

抗ウイルス自然免疫機構の解析

ライフサイエンス基礎科学研究 2004年 - 2009年
Analysis on antiviral innate immunity

Basic Science Research on Life Science 2004年 - 2009年
生体防御系における遺伝子発現制御
Gene regulation in immune system