NAITO Mikihiko

J-GLOBAL         Last updated: Jun 28, 2019 at 13:37
NAITO Mikihiko
National Institute of Health Sciences
Job title

Research Areas


Academic & Professional Experience

Microbiology, The University of Tokyo
and Biosciences, The University of Tokyo
Post-doctoral fellow, Cancer Institute
Assistant professor, Institute of Applied
Associate professor, Institute of Molecular


Graduate School of Pharmaceutical Sciences, The University of Tokyo
Faculty of Pharmaceutical Sciences, The University of Tokyo

Awards & Honors

1999 Incitement Award of the Japanese Cancer Association


Glyoxalase I is involved in resistance of human leukemia cells to antitumor agents-induced apoptosis.
Blood, 95: 3214-3218 (2000)      2000   [Refereed]
Oncogene, 18: 173-180 (1999)      1999   [Refereed]
Phosphatidylserine externalization is a downstream event of interleukin-1b-converting enzyme family protease activation during apoptosis.
Blood, 89: 2060-2066 (1997)      1997   [Refereed]
Regression of established tumors expressing P-glycoprotein by combination of Adriamycin, cyclosporin derivatives, and MRK-16 antibodies.
J.Natl,Cancer Inst., 89:512-518 (1997)      1997   [Refereed]
Oncogene, 14: 1007-1012 (1997)      1997   [Refereed]
Activation of actin-cleavable ICE family protease CPP-32 during chemothrapeutic agent-induced apoptosis in ovarian carcinoma cell.
Cancer Res., 56: 524-5229 (1996)      1996   [Refereed]
DT-diaphorase as a critical determinant of the sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
Cancer Res., 56: 2823-2826(1996)      1996   [Refereed]
Chromosome 22 complements apoptosis in Fas-and TNF-resistant mutant UK110 cells.
Oncogene, 13: 39-46 (1996)      1996   [Refereed]
Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials.
Cancer Res., 56: 875-879 (1996)      1996   [Refereed]
Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells.
Cancer Res., 55: 2186-2190 (1995)      1995   [Refereed]
Nonenzymatic reductive activation of 7-N-{{2-{[2-(gamma-L-glutamylamino)ethyl]dithio}ethyl}} mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Cancer Res., 54: 2398-2403 (1994)      1994   [Refereed]
Expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells of patients with granular lymphocyte-proliferative disorders.
Blood, 81: 1342-1346 (1993)      1993   [Refereed]
Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance.
J.Natl.Cancer Inst., 85:311-316 (1993)      1993   [Refereed]
Functional involvement of P-glycoprotein in blood-brain barrier.
J.Biol.Chem., 267: 20383-20391 (1992)      1992   [Refereed]
Cellular pharmacology of MX2, a new morpholino anthracycline, in human pleiotropic drug-resistant cells.
Cancer Res., 51: 157-161 (1991)      1991   [Refereed]
Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.
Cancer Res., 49: 1452-1455 (1989)      1989   [Refereed]
ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 Cells.
J.Biol.Chem.,263: 11887-11891 (1988)      1988   [Refereed]
Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell
Cancer Res., 53: 5022-5027 (1993)   

Research Grants & Projects

Molecular mechanism of anti-cancer drug resistance Molecular mechanism of cell death