NAITO Mikihiko

J-GLOBAL         Last updated: Jun 28, 2019 at 13:37
 
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Name
NAITO Mikihiko
Affiliation
National Institute of Health Sciences
Job title
Manager(Dean)
Degree
Ph.D

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Microbiology, The University of Tokyo
 
 
   
 
and Biosciences, The University of Tokyo
 
1987
 - 
1989
Post-doctoral fellow, Cancer Institute
 
1989
 - 
1995
Assistant professor, Institute of Applied
 
1995
 - 
2004
Associate professor, Institute of Molecular
 

Education

 
 
   
 
Graduate School of Pharmaceutical Sciences, The University of Tokyo
 
 
   
 
Faculty of Pharmaceutical Sciences, The University of Tokyo
 

Awards & Honors

 
 
1999 Incitement Award of the Japanese Cancer Association
 

Misc

 
Glyoxalase I is involved in resistance of human leukemia cells to antitumor agents-induced apoptosis.
Blood, 95: 3214-3218 (2000)      2000   [Refereed]
Oncogene, 18: 173-180 (1999)      1999   [Refereed]
Phosphatidylserine externalization is a downstream event of interleukin-1b-converting enzyme family protease activation during apoptosis.
Blood, 89: 2060-2066 (1997)      1997   [Refereed]
Regression of established tumors expressing P-glycoprotein by combination of Adriamycin, cyclosporin derivatives, and MRK-16 antibodies.
J.Natl,Cancer Inst., 89:512-518 (1997)      1997   [Refereed]
Oncogene, 14: 1007-1012 (1997)      1997   [Refereed]
Activation of actin-cleavable ICE family protease CPP-32 during chemothrapeutic agent-induced apoptosis in ovarian carcinoma cell.
Cancer Res., 56: 524-5229 (1996)      1996   [Refereed]
DT-diaphorase as a critical determinant of the sensitivity to mitomycin C in human colon and gastric carcinoma cell lines.
Cancer Res., 56: 2823-2826(1996)      1996   [Refereed]
Chromosome 22 complements apoptosis in Fas-and TNF-resistant mutant UK110 cells.
Oncogene, 13: 39-46 (1996)      1996   [Refereed]
Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials.
Cancer Res., 56: 875-879 (1996)      1996   [Refereed]
Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells.
Cancer Res., 55: 2186-2190 (1995)      1995   [Refereed]
Nonenzymatic reductive activation of 7-N-{{2-{[2-(gamma-L-glutamylamino)ethyl]dithio}ethyl}} mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor cells.
Cancer Res., 54: 2398-2403 (1994)      1994   [Refereed]
Expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells of patients with granular lymphocyte-proliferative disorders.
Blood, 81: 1342-1346 (1993)      1993   [Refereed]
Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance.
J.Natl.Cancer Inst., 85:311-316 (1993)      1993   [Refereed]
Functional involvement of P-glycoprotein in blood-brain barrier.
J.Biol.Chem., 267: 20383-20391 (1992)      1992   [Refereed]
Cellular pharmacology of MX2, a new morpholino anthracycline, in human pleiotropic drug-resistant cells.
Cancer Res., 51: 157-161 (1991)      1991   [Refereed]
Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.
Cancer Res., 49: 1452-1455 (1989)      1989   [Refereed]
ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 Cells.
J.Biol.Chem.,263: 11887-11891 (1988)      1988   [Refereed]
Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell
Cancer Res., 53: 5022-5027 (1993)   

Research Grants & Projects

 
Molecular mechanism of anti-cancer drug resistance Molecular mechanism of cell death