白石昌彦 (Masahiko Shiraishi) - マイポータル

基本情報

所属: 国際医療福祉大学薬学部教授

学位: 薬学博士(北海道大学)

J-GLOBAL ID: 200901062875540886
researchmap会員ID: 0000033447

研究キーワード

研究分野

ライフサイエンス / 分子生物学 /

経歴

2010年4月 - 現在

国際医療福祉大学薬学部教授
2005年4月 - 2010年3月

国際医療福祉大学薬学部助教授（准教授）
2000年4月 - 2005年3月

国立がんセンター研究所DNAメチル化と
2000年4月

- Project Leader,
1995年4月 - 2000年3月

国立がんセンター研究所腫瘍遺伝子研究部室長
1995年4月 - 2000年3月

Section Head,
1992年6月 - 1995年3月

国立がんセンター研究所腫瘍遺伝子研究部研究員
1992年6月 - 1995年3月

Staff Scientist,
1990年6月 - 1992年6月

米国マサチューセッツ工科大学博士研究員
1990年6月 - 1992年6月

Postdoctoral Associate, MIT
1985年4月 - 1990年6月

国立がんセンター研究所腫瘍遺伝子研究部研究員
1985年4月 - 1990年6月

Staff Scientist,
ゲノム機能プロジェクトプロジェクトリーダー
Natl. Cancer Ctr. Res. Inst.
DNA methylation and genome function project,
Oncogene Div., Natl Cancer Ctr. Res. Inst.
Oncogene Div., Natl. Cancer Ctr. Res. Inst.
Oncogene Div., Natl. Cancer Ctr. Res. Inst.

学歴

受賞

論文

Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2 '-deoxycytidine in Neuro-2a cells

Naoki Ishimaru, Mamoru Fukuchi, Akina Hirai, Yusuke Chiba, Tomonari Tamura, Nami Takahashi, Akiko Tabuchi, Masaaki Tsuda, Masahiko Shiraishi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 394(1) 173-177 2010年3月査読有り
Bisulfite modification for analysis of DNA methylation

Hikoya Hayatsu, Masahiko Shiraishi, Kazuo Negishi

Current Protocols in Nucleic Acid Chemistry Chapter 6(33) 6.10.15 2008年査読有り
Chemistry of bisulfite genomic sequencing; advances and issues.

Hayatsu H, Negishi K, Shiraishi M, Tsuji K, Moriyama K

Nucleic acids symposium series (2004) (51) 47-48 2007年査読有り
Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells

N Takami, K Osawa, Y Miura, K Komai, M Taniguchi, M Shiraishi, K Sato, T Iguchi, K Shiozawa, A Hashiramoto, S Shiozawa

ARTHRITIS AND RHEUMATISM 54(3) 779-787 2006年3月査読有り
Segregation of partly melted DNA molecules

M Shiraishi, T Sekiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 25(4-6) 463-473 2006年査読有り
High-speed conversion of cytosine to uracil in bisulfite genomic sequencing analysis of DNA methylation.

Shiraishi M, Hayatsu H

DNA research : an international journal for rapid publication of reports on genes and genomes 11(6) 409-415 2004年12月査読有り
Segregation of partly melted molecules: isolation of CpG islands by polyacrylamide gel electrophoresis

M Shiraishi, AJ Oates, Li, X, YH Chuu, T Sekiya

BIOLOGICAL CHEMISTRY 385(10) 967-973 2004年10月査読有り
Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells

M Tani, J Ito, M Nishioka, T Kohno, K Tachibana, M Shiraishi, S Takenoshita, J Yokota

GENES CHROMOSOMES & CANCER 40(2) 146-151 2004年6月査読有り
Methyl-CpG binding domain column chromatography as a tool for the analysis of genomic DNA methylation

M Shiraishi, A Sekiguchi, AJ Oates, MJ Terry, Y Miyamoto, T Sekiya

ANALYTICAL BIOCHEMISTRY 329(1) 1-10 2004年6月査読有り
Denaturing gradient gel electrophoresis to detect methylation changes in DNA.

Shiraishi M

Methods in molecular biology (Clifton, N.J.) 287 219-231 2004年査読有り
Accelerated bisulfite-deamination of cytosine in the genomic sequencing procedure for DNA methylation analysis.

Hayatsu H, Negishi K, Shiraishi M

Nucleic acids symposium series (2004) (48) 261-262 2004年査読有り
Allelic loss of DNA locus of the RET proto-oncogene in small cell lung cancer

H Futami, S Egawa, K Takasaki, T Tsukada, M Shiraishi, K Yamaguchi

CANCER LETTERS 195(1) 59-65 2003年5月査読有り
Treatment of tumor cells with histone deacetylase inhibitors results in altered recruitment of methyl-CpG binding proteins to a methylated CpG island

S Koizume, K Tachibana, M Shiraishi

BIOLOGICAL CHEMISTRY 384(5) 787-790 2003年5月査読有り
Koizume, S., Sekiya, T., and Shiraishi, M. Specific methylation status of the entire CpG island is not a prerequisite for the formation of an inactive chromatin at the promoter region in cancer cells.

Biol. Pharm. Bull 26 127-128 2003年査読有り
An overview of the analysis of DNA methylation in mammalian genomes

M Shiraishi, AJ Oates, T Sekiya

BIOLOGICAL CHEMISTRY 383(6) 893-906 2002年6月査読有り
A comprehensive catalog of CpG islands methylated in human lung adenocarcinomas for the identification of tumor suppressor genes

M Shiraishi, A Sekiguchi, MJ Terry, AJ Oates, Y Miyamoto, YH Chuu, M Munakata, T Sekiya

ONCOGENE 21(23) 3804-3813 2002年5月査読有り
HOX gene clusters are hotspots of de novo methylation in CpG islands of human lung adenocarcinomas

M Shiraishi, A Sekiguchi, AJ Oates, MJ Terry, Y Miyamoto

ONCOGENE 21(22) 3659-3662 2002年5月査読有り
Koizume, S., Tachibana, K., Sekiya, T., Hirohashi, S., and Shiraishi, M. Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.

Nucleic Acids Res. 30, 4770-4780 2002年
Shiraishi, M., Sekiguchi, A., Oates, A. J., Terry, M. J., Miyamoto, Y., Tanaka, K., and Sekiya, T. Variable estimation of genomic DNA methylation: a comparison of methyl-CpG binding domain column chromatography and bisulfite genomic sequencing.

Anal. Biochem. 308, 182-185 2002年
Heterogeneity in the methylation status of genomic DNA fragments demonstrating similar elution profiles in methyl-CpG binding domain column chromatography

M Shiraishi, A Sekiguchi, A Oates, M Terry, Y Miyamoto, T Sekiya

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 77(10) 208-211 2001年12月査読有り

もっとみる

MISC

Futami, H., Egawa, S., Takasaki, K., Tsukada, T., Shiraishi, M., and Yamaguchi, K. Allelic loss of DNA locus of the RET proto-oncogene in small cell lung cancer.

Cancer Lett. (195) 59-65 2003年
Koizume, S., Tachibana, K., and Shiraishi, M. Treatment of tumor cells with histone deacetylase inhibitors results in altered recruitment of methyl-CpG binding proteins to a methylated CpG island.

Biol Chem. (384) 787-790 2003年
Shiraishi, M., Oates, A. J., and Sekiya, T. An overview of the analysis of DNA methylation in mammalian genomes.

Biol. Chem. (383) 863-906 2002年
Shiraishi, M., Sekiguchi, A., Terry, M. J., Oates, A. J., Miyamoto, Y., Chuu, Y. H., Munakata, M., and Sekiya, T. A comprehensive catalog of CpG islands methylated in human lung adenocarcinomas for the identification of tumor suppressor genes.

Oncogene (21) 3804-3813 2002年
Shirishi, M., Sekiguchi, A., Oates, A. J., Terry, M. J., and Miyamoto, Y. HOX gene clusters and hotspots of de novo methylation in CpG islands of huma lung adenocarcinomas.

Oncogene (21) 3659-3662 2002年
Shiraishi, M., Oates, A. J., and Sekiya, T. An overview of the analysis of DNA methylation in mammalian genomes.

Biol. Chem. 383, 893-906 2002年
Shiraishi, M., Sekiguchi, A., Terry, M. J., Oates, A. J., Miyamoto, Y., Chuu, Y. H., Munakata, M., and Sekiya, T. A comprehensive catalog of CpG islands methylated in human lung adenocarcinomas for the identification of tumor suppressor genes.

Oncogene 21, 3804-3813 2002年
Shiraishi, M., Sekiguchi, A., Oates, A. J., Terry M. J., and Miyamoto, Y. HOX gene clusters are hotspots of de novo methylation in CpG islands of human lung adenocarcinomas.

Oncogene 21, 3659-3662 2002年
Shiraishi, M., Sekiguchi, A., Oates, A., Terry, M., Miyamoto, Y., and Sekiya, T. Heterogeneity in the methylation status of genomic DNA fragments demonstrating similar elution profiles in methyl-CpG binding domain column chromatography.

Proc. Jpn. Acad. (77(B)) 208-211 2001年
[SPM, a method for isolation of CpG islands: application of stability of partly melted molecules].

Shiraishi M

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 44(10) 1519-1524 1999年8月査読有り
Kawakami, K., Yasuda, J., Shiraishi, M., Kayama, T., Doi, K., Perucho, M., and Sekiya, T. Detection of DNA abnormalities by arbitrarily primed PCR fingerprinting: allelic losses in chromosome 10q in lung cancers. Biochem. Biophys.

Res. Commun. (251) 153-157 1998年
[DNA methylation and CpG islands].

Shiraishi M

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 41(15 Suppl) 2288-2295 1996年11月査読有り
Shiraishi, M. and Sekiya, T. Mutations in an Alu repeated sequence associated with the DXS43 locus in human small cell lung cancers.

Oncogene (10) 1453-1454 1995年
Sachse, R., Murakami, Y., Shiraishi, M., Hayashi, K., and Sekiya, T. Absence of activating mutations in the transmembrane domain of the c-erbB-2 in human lung cancer.

Jpn. J. Cancer Res. (83) 1299-1303 1992年
Kishimoto, Y., Murakami, Y., Shiraishi, M., Hayashi, K., and Sekiya, T. Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung.

Cancer Res. (52) 4799-4804 1992年
Mäkelä, T. P., Shiraishi, M., Borrello, M. G., Sekiya, T., and Alitalo, K. Rearrangement and coamplification of L-myc and rlf in primary lung cancer.

Oncogene (7) 405-409 1992年
Iizuka, M., Shiraishi, M., Hayashi, K., and Sekiya, T. Three RFLPs of anonymous DNA Sequence D8S586 on human chromosome 8.

Nucleic Acids Res. (19) 680 1991年
Tahira, T., Shiraishi, M., Ishizaka, Y., Ikeda, I., Sakai, R., Sugimura, T., and Nagao, M. A Taq I RFLP in the human ret proto-oncogene.

Nucleic Acids Res. (18) 7472 1990年
Suzuki, Y., Orita, M., Shiraishi, M. Hayashi, K., and Sekiya, T. Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products.

Oncogene (5) 1037-1043 1990年
Iizuka, M., Shiraishi, M., Yoshida, M. C., Hayashi, K., and Sekiya, T. Joining of the MYC gene and an L1 member on chromosome 8 in a human primary giant cell carcinoma of the lung

Cancer Res. (50) 3345-3350 1990年

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

DNAメチル化とヒトゲノムの機能制御

厚生労働科学研究費補助金
DNA methylaton and functional regulation of the human genome

Health and Labour Sciences Research Grants