2009年7月
Pro-apoptotic activity and mono-/diubiquitylation of Xenopus Bid in egg extracts
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 384
- 号
- 4
- 開始ページ
- 491
- 終了ページ
- 494
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2009.05.004
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Apoptosis in Xenopits egg extracts is Carried out by maternally stockpiled materials, but the contributions of endogenous apoptosis regulators are still poorly characterized. Here we examined the physiological role of Xenopus Bid (xBid), a pro-apoptotic BH3-only member of Bcl-2 family proteins. We found that endogenous xBid was a physiological accelerator of apoptosis in egg extracts. Interestingly, xBid was mono-/diubiquitylated but not degraded by proteasome in egg extracts, and we identified three ubiquitylated Lys residues in the N-terminal propeptide region. Comparison with human Bid suggested that mono-/diubiquitylation is a specific feature of xBid. (C) 2009 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bbrc.2009.05.004
- CiNii Articles
- http://ci.nii.ac.jp/naid/80020325460
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/19426713
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000266689300018&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.bbrc.2009.05.004
- ISSN : 0006-291X
- eISSN : 1090-2104
- CiNii Articles ID : 80020325460
- PubMed ID : 19426713
- Web of Science ID : WOS:000266689300018