ARAI Masayoshi

J-GLOBAL         Last updated: Nov 15, 2019 at 03:30
 
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Name
ARAI Masayoshi
Affiliation
Osaka University
Section
Graduate School of Pharmaceutical Sciences Drug Innovation Center
Job title
Specially Appointed Professor
Degree
-(Kitasato University)
Other affiliation
Osaka UniversityOsaka UniversityOsaka University

Research Areas

 
 

Published Papers

 
Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5.
1. I.G.U. Pait, S. Kitani, F.W. Roslan, D. Ulanova, M. Arai, H. Ikeda, T. Nihira
Journal of Industrial Microbiology & Biotechnology      Dec 2017   [Refereed]
2. D.A. Suroto, S. Kitani, K.T. Miyamoto, Y. Sakihama, M. Arai, H. Ikeda, T. Nihira
J. Biosci. Bioeng.      Nov 2017   [Refereed]
2. M. Arai, K. Kamiya, D. Shin, H. Matsumoto, T. Hisa, A. Setiawan, N. Kotoku, M. Kobayashi
Chem. Pharm. Bull.   64(7) 766-771   Jul 2016   [Refereed]
2. M. Arai, K. Kamiya, D. Shin, H. Matsumoto, T. Hisa, A. Setiawan, N. Kotoku, M. Kobayashi
Chem. Pharm. Bull.   64(7) 766-771   Jul 2016   [Refereed]
M. Arai, Y. Yamano, K. Kamiya, A. Setiawan, M. Kobayashi
J. Nat. Med.      May 2016   [Refereed]
M. Arai, Y. Yamano, K. Kamiya, A. Setiawan, M. Kobayashi
J. Nat. Med.   70(3) 467-475   May 2016   [Refereed]
2. M. Arai, T. Kawachi, N. Kotoku, C. Nakata, H. Kamada, S. Tsunoda, Y. Tsutsumi, H. Endo, M. Inoue, H. Sato, M. Kobayashi,
ChemBioChem      Nov 2015   [Refereed]
Naoyuki Kotoku *, Shinichi Fujioka, Chiaki Nakata, Masaki Yamada, Yuji Sumii, Takashi Kawachi, Masayoshi Arai, Motomasa Kobayashi *
Tetrahedron   67(35) 6673-6678   Sep 2011   [Refereed][Invited]
Structure-activity relationship of furospinosulin-1 (1), a hypoxia-selective growth inhibitor isolated from marine sponge, was investigated. Concise synthetic method of 1 was developed, and some structurally modified analogues were prepared. Biolo...
Pruksakorn P., Arai M.*, Liu L., Moodley P., Jacobs Jr. W.R., Kobayashi M.*
Biol. Pharm. Bull.   34(8) 1287-1290   Aug 2011   [Refereed]
Arai M.*, Liu L., Fujimoto T., Setiawan A., Kobayashi M.*
Marine Drugs   96(6) 984-993   Jun 2011   [Refereed]
Ishida S., Arai M.*, Nikawa H., Kobayashi M.*
Biol. Pharm. Bull.   34(6) 917-920   Jun 2011   [Refereed]
Arai M., Hayashi A., Sobou M., Ishida S., Kawachi T., Kotoku N., Kobayashi M.
J. Nat. Med.   65(1) 149-156   2011
Arai M.*, Kawachi T., Setiawan A., Kobayashi M.*
ChemMedChem   5(11) 1919-1926   Nov 2010   [Refereed]
Kotoku N., Guo X.H., Arai M., Kobayashi M.
Bioorg. Med. Chem. Lett.   20(14), 4152-4155.(14) 4152-4155   Jul 2010   [Refereed]
Syntheses of biotinylated probe molecules of L-glutathione (GSH) equipped with boronic acid moiety and evaluation of their binding affinities against glutathione-S-transferase (GST) were described. It revealed that the presence of boronic acid moi...
Pruksakorn P., Arai M., Kotoku N., Vilcheze C, Baughn A.D., Moodley P., Jacobs W.R., Jr., Kobayashi M.
Bioorg. Med. Chem. Lett.   20(12), 3658-3663.(12) 3658-3663   Jun 2010   [Refereed]
Arai M., Ishida S., Setiawan A., Kobayashi M.
Chem. Pharm. Bull   57(10) 1136-1138   Oct 2009   [Refereed]
Hayashi A., Arai M., Fujita M., Kobayashi M.
Biol. Pharm. Bull.   32(7) 1261-1265   Jul 2009   [Refereed]
Suna H., Arai M., Tsubotani Y., Hayashi A., Setiawan A., Kobayashi M.
Bioorg. Med. Chem.   17(11) 3968-3972   Jun 2009   [Refereed]
Arai M., Sobou M., Vilcheze C., Baughn A., Hashizume H., Pruksakorn P., Ishida S., Matsumoto M., Jacobs W.R., Jr., Kobayashi M.
Bioorg. Med. Chem.   16(14) 6732-6736   Jul 2008   [Refereed]
Aoki S., Watanabe Y., Tanabe D., Arai M., Suna H., Miyamoto K., Tsujibo H., Tsujikawa K., Yamamoto H., Kobayashi M.
Bioorg. Med. Chem.   15(21) 6758-6762   Nov 2007   [Refereed]
Wei H., Inada H., Hayashi A., Higashimoto K., Pruksakorn P., Kamada S., Arai M., Ishida S., Kobayashi M.
J. Antibiot.   60(9) 586-590   Sep 2007   [Refereed]
Iwatsuki M., Uchida R., Takakusagi Y., Matsumoto A., Jiang C.L., Takahashi Y., Arai M., Kobayashi S., Matsumoto M., Inokoshi J., Tomoda H., Omura S.
J. Antibiot.   60(6) 357-363   Jun 2007   [Refereed]
Aoki S., Watanabe Y., Tanabe D., Setiawan A., Arai M., Kobayashi M.
Tetrahedron Lett.   48(26) 4485-4488   Jun 2007   [Refereed]
Aoki S., Sanagawa M., Watanabe Y., Setiawan A., Arai M., Kobayashi M.
Bioorg. Med. Chem.   15(14) 4818-4828   Jun 2007   [Refereed]
Zimhony O., Vilcheze C., Arai M., Welch J.T., Jacobs W.R., Jr.
Antimicrob. Agents Chemother.   51(2) 752-754   Feb 2007   [Refereed]
Vilcheze C., Wang F., Arai M., Hazbon M.H., Colangeli R., Kremer L., Weisbrod T.R., Alland D., Sacchettini J.C., Jacobs W.R., Jr.
Nat. Med.   12(9) 1027-1029   Sep 2006   [Refereed]
Koizumi Y., Arai M., Tomoda H., Omura S.
J. Antibiot.   57(7) 415-420   Oct 2004   [Refereed]
Arai M., Koizumi Y., Sato H., Kawabe T., Suganuma M., Kobayashi H., Tomoda H., Omura S.
J. Antibiot.   57(10) 662-668   Oct 2004   [Refereed]
Koizumi Y., Arai M., Tomoda H., Omura S.
Biochim. Biophys. Acta.,   1693(1) 47-55   Jul 2004   [Refereed]
Analysis of the mechanism of anti-mycotic activities by azoles potentiated by new erythromycin derivatives.
Omura S., Arai M., Sato K., Nagamitsu T., Nagai K., Sunazuka T., Tomoda H.
Jpn. J. Antibiot.   57(Suppl A) 96-100   Jun 2004
Arai M., Sato H., Kobayashi H., Suganuma M., Kawabe T., Tomoda H., Omura S.
Biochem. Biophys. Res. Commun.   317(3) 817-822   May 2004   [Refereed]
Fukuda T., Arai M., Tomoda H., Omura S.
J. Antibiot.   57(2) 117-124   Feb 2004   [Refereed]
Fukuda T., Arai M., Yamaguchi Y., Masuma R., Tomoda H., Omura S.
J. Antibiot.   57(2) 110-116   Feb 2004   [Refereed]
Yamamoto K., Hatano H., Arai M., Shiomi K., Tomoda H., Omura S.
J. Antibiot.      Jun 2003   [Refereed]
Arai M., Yamamoto K., Namatame I., Tomoda H., Omura S.
J. Antibiot.   56(6) 526-532   Jun 2003   [Refereed]
Tomoda H., Arai M., Koyama N., Matsui H., O mura S., Obata R., Lee Y.C.
Anal. Biochem.   311(1), 50-56.    Dec 2002   [Refereed]
Arai M., Tomoda H., Okuda T., Wang H., Tabata N., Masuma R., Yamaguchi Y., Omura S.
J. Antibiot.   55(2) 172-180   Feb 2002   [Refereed]
Yamaguchi Y., Masuma R., Uchida R., Arai M., Tomoda H., Omura S.
Mycoscience   43(2) 127-133   Jan 2002   [Refereed]
Uchida R., Tomoda H., Arai M., Omura S.
J. Antibiot.   54(11), 882-889.    Nov 2001   [Refereed]
Arai M., Tomoda H., Tabata N., Ishiguro N., Kobayashi S., Omura S.
J. Antibiot.   54(7) 562-566   Jul 2001   [Refereed]
Arai M., Tomoda H., Matsumoto A., Takahashi Y., Woodruff B.H., Ishiguro N., Kobayashi S., Omura S.
J. Antibiot.   54(7) 554-561   Jul 2001   [Refereed]
Arai, M., Tomoda, H., Matsumoto, A., Takahashi, Y., Woodruff,. Boyd H., Ishiguro, N., Kobayashi, S. and Omura, S. Deacetylravidomycin M, A New Inhibitor of IL-4 Signal Transduction, Produced by 〈i〉Streptomyces〈/i〉Sp. WK-6326. I. Taxonomy, Fermenta...
Namatame I., Tomoda H., Arai M., Omura S.
J. Antibiot.   53(1) 19-25   Jan 2000   [Refereed]
Nomura K., Imai H., Koumura T., Arai M., Nakagawa Y.
J. Biol. Chem.   274(41), 29294-29302.(41) 29294-29302   Oct 1999   [Refereed]
Chiba N., Imai H., Narashima K., Arai M., Oshima G., Kunimoto M., Nakagawa Y.
Biol. Pharm. Bull.   22(10) 1047-1051   Oct 1999   [Refereed]
Arai M., Imai H., Koumura T., Yoshida M., Emoto K., Umeda M., Chiba N., Nakagawa Y.
J. Biol. Chem.   274(8), 4924-4933.(8) 4924-4933   Feb 1999   [Refereed]
Imai H., Narashima K., Arai M., Sakamoto H., Chiba N., Nakagawa Y.
J. Biol. Chem.   273(4), 1990-1997.    Jan 1998   [Refereed]
Arai M., Imai H., Metori A., Nakagawa Y.
Eur. J. Biochem.   244(2), 513-519.    Mar 1997   [Refereed]
Arai M., Imai H., Sumi D., Imanaka T., Takano T., Chiba N., Nakagawa Y.
Biochem. Biophys. Res. Commun.   227(2), 433-439.    Oct 1996   [Refereed]
Imai H., Sumi D., Sakamoto H., Hanamoto A., Arai M., Chiba N., Nakagawa Y.
Biochem. Biophys. Res. Commun.   222(2), 432-438.    May 1996   [Refereed]
Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression.
Imai H., Sumi D., Hanamoto A., Arai M., Sugiyama A., Chiba N., Kuchino Y., Nakagawa Y.
J. Biochem.   118(5), 1061-1067.    Jul 1995   [Refereed]
Structure-activity relationship of biakamide, selective growth inhibitors under nutrient-starved condition from marine sponge.
R. Ishida, H. Matsumoto, S. Ichii, M. Kobayashi, M. Arai, N. Kotoku
Chem. Pharm. Bull.   67(3) 210-223   Jan 2019   [Refereed]
Target identification of the marine natural products dictyoceratin-A and -C as selective growth inhibitors in cancer cells adapted to hypoxic environments.
T. Kawachi, S. Tanaka, A. Fukuda, Y. Sumii, A. Setiawan, N. Kotoku, M. Kobayashi, M. Arai
Mar. Drugs   17(3) -E163   Mar 2019   [Refereed]
In vitro study on α-amylase inhibitory and α-glucosidase of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina.
H.L.T. Anh, L.B. Vinh, L.T. Lien, P.V. Cuong, M. Arai, T.P. Ha, H.N. Lin, T.T.H. Dat, L.C.V. Cuong, Y.H. Kim.
Nat. Prod. Res.   1-7   Mar 2019   [Refereed]
Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression.
S. Ueda, H. Ikeda, T. Namba, Y. Ikejiri, Y. Nishimoto, M. Arai, T. Nihira, S. Kitani
J. Ind. Microbiol. Biotechnol.   46(5) 739-750   Apr 2019   [Refereed]
Structural elucidation of glycosides from the seeds of Entada phaseoloides growing in Thua Thien Hue.
L.C.V. Cuong, L.T. Lien, N.P.K. Nhi, T.P. Ha, L.T. Anh, M. Arai, H.L.T. Anh
Vietnam J. Sci. Technol.   57(2) 170-178   Apr 2019   [Refereed]
Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity.
H.H.H. Mohammed, E.M.N. Abdelhafez, S.H. Abbas, G.A.I. Moustafa, G. Hauk, J.M. Berger, S. Mitarai, M. Arai, R.M. Abd El-Baky, G.E.A. Abuo-Rahma
Bioorg. Chem.   88 -102952   Apr 2019   [Refereed]
Cytotoxicity of new diterpene alkaloids, ceylonamides G-I, isolated from Indonesian marine sponge of Spongia sp.
T. Jomori, A. Setiawan, M. Sasaoka, M. Arai
Nat. Prod. Commun.   -in press   May 2019   [Refereed]
Structure-activity relationship of biakamide, selective growth inhibitors under nutrient-starved condition from marine sponge.
R. Ishida, H. Matsumoto, S. Ichii, M. Kobayashi, M. Arai, N. Kotoku
Chem. Pharm. Bull.   67(3) 210-223   Jan 2019   [Refereed]
Target identification of the marine natural products dictyoceratin-A and -C as selective growth inhibitors in cancer cells adapted to hypoxic environments.
T. Kawachi, S. Tanaka, A. Fukuda, Y. Sumii, A. Setiawan, N. Kotoku, M. Kobayashi, M. Arai
Mar. Drugs   17(3) -E163   Mar 2019   [Refereed]
In vitro study on α-amylase inhibitory and α-glucosidase of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina.
H.L.T. Anh, L.B. Vinh, L.T. Lien, P.V. Cuong, M. Arai, T.P. Ha, H.N. Lin, T.T.H. Dat, L.C.V. Cuong, Y.H. Kim.
Nat. Prod. Res.   1-7   Mar 2019   [Refereed]
Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression.
S. Ueda, H. Ikeda, T. Namba, Y. Ikejiri, Y. Nishimoto, M. Arai, T. Nihira, S. Kitani
J. Ind. Microbiol. Biotechnol.   46(5) 739-750   Apr 2019   [Refereed]
Structural elucidation of glycosides from the seeds of Entada phaseoloides growing in Thua Thien Hue.
L.C.V. Cuong, L.T. Lien, N.P.K. Nhi, T.P. Ha, L.T. Anh, M. Arai, H.L.T. Anh
Vietnam J. Sci. Technol.   57(2) 170-178   Apr 2019   [Refereed]
Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity.
H.H.H. Mohammed, E.M.N. Abdelhafez, S.H. Abbas, G.A.I. Moustafa, G. Hauk, J.M. Berger, S. Mitarai, M. Arai, R.M. Abd El-Baky, G.E.A. Abuo-Rahma
Bioorg. Chem.   88 -102952   Apr 2019   [Refereed]
Cytotoxicity of new diterpene alkaloids, ceylonamides G-I, isolated from Indonesian marine sponge of Spongia sp.
T. Jomori, A. Setiawan, M. Sasaoka, M. Arai
Nat. Prod. Commun.   -in press   May 2019   [Refereed]

Misc

 
Masayoshi Arai
Yakugaku Zasshi   136(4) 669-676   Jan 2016   [Refereed][Invited]
Search for New Medicinal Seed and Identification of Target Molecule on the Basis of Phenotypic Screening
Masayoshi Arai
Yakugaku Zasshi      Nov 2015   [Refereed][Invited]
Masayoshi Arai, Motomasa Kobayashi
68(5), 470-479(5) 470-479   Jan 2010   [Refereed][Invited]
Arai, M., Imai, H., Koumura, T., Yoshida, M., Emoto, K., Umeda, M., Chiba, N. And Nakagawa, Y. Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays A Major Role in Preventing Oxidative Injury to Cells.
J. Biol. Chem   274.4924-4933    1999
Arai, M., Imai, H., Metori, A. and Nakagawa, Y. Preferential Esterication of Endogenously Formed 5-Hydroxyeicosatetraenoic Acid to Phospholipids in Activated Polymorphonuclear Leukocytes.
Eur. J. Biochem.   244.5130519    1997
Arai, M., Imai, H., Sumi, D., Imanaka, T., Takano, T., Chiba, N. and Nakagawa, Y. Import into Mitochondria of Phospholipid Hydroperoxide Glutathione Peroxidase rewuires A Leader Sequence.
Biochem. Biophys. Res. Commun.   227.433-439    1997
Chiba, N., Imai, H., Narashima, K., Arai, M., Oshima, G., Kunimoto, M., and Nakagawa, Y. Cellular Glutathione Peroxidase as A Predominant Scavenger of Hydroperoxyeicosatetraenoic Acid in Rabbit Alveolar Macrophages.
Biol. Pharm. Bull.   22.1047-1051    1999
Imai, H., Narashima, K., Arai, M., Sakamoto, H., Chiba, N. and Nakagawa, Y. Sppression of Leukotriene Formation in RBL-2H3 Cells That Overexpressed Phospholipid Hydroperoxide Glutathione Peroxidase.
J. Biol. Chem.   273.1990-1997    1998
Imai, H., Sumi, D., Hanamoto, A., Arai, M., Sugiyama, A., Chiba, N., Kuchino, Y. and Nakagawa, Y. Molecular Cloning and Functional Expression of A cDNA for Rat Phospholipid Hydroperoxide Glutathione Peroxidase : 3`-untranslated Region of The Gene is Ne・・・
J. Biochem.   118.1061-1067    1995
Imai, H., Sumi, D., Hanamoto, A., Arai, M., Sugiyama, A., Chiba, N., Kuchino, Y. and Nakagawa, Y. Molecular Cloning and Functional Expression of A cDNA for Rat Phospholipid Hydroperoxide Glutathione Peroxidase : 3`-untranslated Region of The Gene ...
Imai, H., Sumi, D., Sakamoto, H., Hanamoto, A., Arai, M., Chiba, N. and Nakagawa, Y. Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Suppressed Cell Death Due to Oxidative Damage in Rat Basophile Leukemia Cells(RBL-2H3).
Biochem. Biophys. Res. Commun.   222.432-438    1996
Namatame, I., Tomoda, H., Arai, M. and Omura, S. Effect of Fungai metabolites Cytochalasans on Lipid Droplet Formation in Mouse Macrophages.
J. Antibiot.   53.19-25    2000
Nomura, K., Imai, H., Koumura, T., Arai. M. and Nakagawa, Y. Mitochondrial Death Pathway J.
Biol Chem.   274.29294-29302    1999
Tomoda, H., Arai, M., Koyama, N., Matsui, H., Omura, S., Obata, R., and Lee, Y.C. Purification of Shiga-like Toxin 1 by Pigeon Egg White Glycoproteins Immobilized on Sepharose Gels.
Anal Biochem.   311, 50-56    2002
Uchida, R., Tomoda, H., Arai, M. and Omura, S. Chlorogentisylquinone, A New Neutral Sphingomyelinase Inhibitor, Produced by A Marine Fungus.
J. Antibiot.   54.882-889    2001

Research Grants & Projects

 
Screening of anti-arterosclerosis drug from microbial metabolite
Screening of anti-infection diesase drug from microbial metabolite