2021年7月
Asymmetric Formal Synthesis of Trichodermamides B and C
SYNLETT
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- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1055/s-0040-1720383
- 出版者・発行元
- GEORG THIEME VERLAG KG
An asymmetric formal synthesis of trichodermamides B and C was achieved in 15 steps based on a tyrosine ester chiral-pool approach. Key features of this synthesis include stereoselective construction of a cis -1,2-oxazadecaline core by an acid-mediated tandem deprotection-intramolecular oxy-Michael reaction, oxime ether formation via an N -bromination-elimination sequence, and diene construction by a palladium-catalyzed demonomethylcarbonation.
- リンク情報
- ID情報
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- DOI : 10.1055/s-0040-1720383
- ISSN : 0936-5214
- eISSN : 1437-2096
- Web of Science ID : WOS:000675178800001