MISC

2002年5月

Effects of STA(2), a thromboxane A(2) mimetic, in inducing airflow obstruction and airway microvascular leakage in guinea pigs

PHARMACOLOGY
  • Y Inoue
  • ,
  • K Tokuyama
  • ,
  • H Nishimura
  • ,
  • H Arakawa
  • ,
  • M Kato
  • ,
  • H Mochizuki
  • ,
  • A Morikawa

65
2
開始ページ
62
終了ページ
68
記述言語
英語
掲載種別
DOI
10.1159/000056188
出版者・発行元
KARGER

Background: U-46619, a thromboxane A(2) (TXA(2)) mimetic, is shown to cause airway microvascular leakage, although the effects is weak when comparing with that to induce bronchoconstriction in guinea pigs. Objective: In order to know the airway effect of TXA(2) more accurately, we have examined the effects of STA(2), a TXA(2) mimetic with higher affinity to TXA(2) (TP) receptors than U-46619, to induce airway microvascular leakage and airflow obstruction. Methods: Anesthetized and ventilated guinea pigs were i.v. given STA(2) (3-30 nmol/kg) or U-46619 (3100 nmol/kg) 1 min after i.v. Evans blue dye. STA(2)- and U-46619-induced increases in lung resistance (R-L) was measured for 6 min. The amount of extravasated Evans blue dye in the lower airways was, then, examined as an index of leakage. In selected animals, specific TP receptor antagonists (10 mug/kg S-1452 or 10 mg/kg ONO-3708) were pretreated i.v. Results: Both STA(2) and U-46619 induced significant increases in leakage and airflow obstruction. However, STA(2) induced a slow and significantly less increase in RL but caused a significantly greater increase in extravasation of Evans blue dye compared to U-46619. Specific TP receptor antagonists completely abolished both airway effects induced by STA(2) and U46619. Conclusion: Our present results have supported a possibility that TXA(2) induces microvascular leakage as well as bronchoconstriction in the airways. Copyright (C) 2002 S. Karger AG, Basel.

リンク情報
DOI
https://doi.org/10.1159/000056188
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000175590200002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1159/000056188
  • ISSN : 0031-7012
  • Web of Science ID : WOS:000175590200002

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