J-GLOBAL         Last updated: Jul 2, 2019 at 02:42
Gifu University
Graduate School of Medicine
Doctor of Medical Sciences(Gifu University)


Microneurosurgery for cerebrovascular disease/Microneurosurgery for brain tumor/Cerebrovascular reconstruction

Research Areas


Academic & Professional Experience

Professor and chairman, Gifu University University Hospital, Neurosurgery, Department of Neurosurgery

Published Papers

Dissecting and fusiform aneurysms of vertebro-basilar systems. MR imaging.
Iwama Toru(Department of Neurosurgery, Gifu University School of Medicine)
32 272-279   Jan 1990
In situ detection of O6-methylguanine-DNA methyltransferase messenger RNA in paraffin-embedded human astrocytic tumourtissues by nested in situ RT-PCR is useful in predicting chemotherapy-resistance of tumors.
Ohe N(Neurosurgery),YanoH(Neurosurgery),Iwama T(Neurosurgery)
22 543-549   Jan 2003
Cell permeable ROS scavengers, tion and tempol, rescue PCl2 cell death caused by pyrogallol or hypoxia/reoxygenation.
Yoshimura S(Neurosurgery),Iwama T(Neurosurgery)
45 1-8   Jan 2003
Fluorescence-guided resection of glioblastoma multiforme by using high-dose fluorescein sodium.
Yano H(Neurosurgery),Yoshimura S(Neurosurgery),Iwama T(Neurosurgery)
99 597-603   Jan 2003
Fluorescence-guided resection of glioblastoma multiforme by using high-dose fluorescein sodium.
186-191   Jan 2003


Yoshitaka Tanaka, Yoshitaka Tanaka, Hidefumi Fukumitsu, Hitomi Soumiya, Shinichi Yoshimura, Toru Iwama, Shoei Furukawa
International Journal of Molecular Sciences   13 4968-4981
In our previous study, we found that trans-2-decenoic acid ethyl ester (DAEE), a derivative of a medium-chain fatty acid, elicits neurotrophin-like signals including the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in cult...
Hirohito Yanou, Noriyuki Nakayama, Naoyuki Ohe, Kazuhiro Miwa, Jun Shinoda, Shin Ichi Yoshimura, Toru Iwama
Journal of the Japan Epilepsy Society   31 2-7
In this literature review, we describe the epidemiology, mechanism of development, and medical or surgical treatment of brain tumor-related epilepsy. We found that 70-90% of patients with low-grade glioma presented with epilepsy, which disappeared...
M. Ishiguro, M. Ishiguro, K. Kawasaki, Y. Suzuki, F. Ishizuka, K. Mishiro, Y. Egashira, I. Ikegaki, K. Tsuruma, M. Shimazawa, S. Yoshimura, T. Iwama, H. Hara
Neuroscience   220 302-312
Thrombolysis with tissue plasminogen activator (tPA) is the only FDA-approved therapy for acute ischemic stroke. However, hemorrhagic transformation, neurotoxicity, and a short treatment time window comprise major limitations for thrombolytic ther...
Yoshiya Toyoshima, Yoshiya Toyoshima, Yoshiya Toyoshima, Yoshitaka Asano, Yoshitaka Asano, Jun Shinoda, Jun Shinoda, Shunsuke Takenaka, Shunsuke Takenaka, Shunsuke Takenaka, Tatsuki Aki, Tatsuki Aki, Tatsuki Aki, Toru Iwama
Brain Injury   25 1212-1220
Objective: The purpose of this study was to highlight a speech expression disorder considered as a mixed speech apraxia (SA) and dysarthria syndrome in patients with chronic severe diffuse brain injury (DBI) and to determine its correlation with a...
Yoshitaka Tanaka, Shinichi Yoshimura, Yusuke Egashira, Kiyofumi Yamada, Yukiko Enomoto, Toru Iwama
Japanese Journal of Neurosurgery   20 678-685
Background and Purpose: Acute basilar artery occlusion (ABAO) is associated with a high rate of mortality and poor clinical outcome in patients treated conservatively. We treated patients with ABAO with aggressive reperfusion therapy in combinatio...

Conference Activities & Talks

An automated bone removal technique for extraction of cerebral vesselsfrom head CT angiography.
Iwama T(Neurosurgery),Hoshi H(Radiology)
Jan 2005   

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1999 - 2000    Investigator(s): Toru IWAMA
Elevation of intracellular ceramide levels has been observed in response to various extracellular stimuli including γ- irradiation, ultraviolet light, and the chemotherapeutic agents and causes apoptosis and/or cell cycle arrest. The addition of e...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2003    Investigator(s): Toru IWAMA
Although the p53 tumor-suppressor gene product plays a critical role in apoptotic cell death induced by DNA-damaging chemotherapeutic agents, human glioma cells with functional p53 were more resistant to gamma-radiation than those with mutant p53....
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2012 - 2013    Investigator(s): Toru IWAMA
This study revealed that shear-induced platelet-derived inflammatory cytokines, such as sCD40L, interleukins, increase in time-dependent manner. In carotid stenosis patients, a significant time-dependent increase of platelet-derived inflammatory c...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: 2012 - 2013
Study on efficacy of cerebral revascularization