2005年9月
Anti-inflammatory activities of alpha-truxillic acid derivatives and their monomer components
BIOLOGICAL & PHARMACEUTICAL BULLETIN
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- 巻
- 28
- 号
- 9
- 開始ページ
- 1776
- 終了ページ
- 1778
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/bpb.28.1776
- 出版者・発行元
- PHARMACEUTICAL SOC JAPAN
The anti-inflammatory activities of alpha-truxillic acid (1) and 4,4'-dihydroxy-alpha-truxillic acid (2) as well as their monomer components (E)-cinnamic acid (3) and (E)-p-coumaric acid (4) were evaluated in the formalin test. alpha-Truxillic acid (1) and its derivative 4,4'-dihydroxy-alpha-truxillic acid (2) exhibited significant activity against inflammatory pain response, while their monomer components (E)-cinnamic acid (3) and (E)-p-coumaric acid (4) did not show any activity against either neurogenic or inflammatory pain responses induced by formalin in mice. These results suggested that the dimeric structure might play an important role for the expression of anti-inflammatory activity. Furthermore, in order to gain information on their potencies, their anti-inflammatory activities were compared with that of incarvillateine (5) which contains the same dimeric structure and showed more potent antinociceptive activity than morphine in the formalin test. The activities of alpha-truxillic acid (1) and 4,4'-dihydroxy-alpha-truxillic acid (2) at the dose of 40 mg/kg against inflammatory pain response were equal to that of incarvillateine at doses of 20 mg/kg.
- リンク情報
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- DOI
- https://doi.org/10.1248/bpb.28.1776
- CiNii Articles
- http://ci.nii.ac.jp/naid/110003666511
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16141559
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000231774300047&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1248/bpb.28.1776
- ISSN : 0918-6158
- CiNii Articles ID : 110003666511
- PubMed ID : 16141559
- Web of Science ID : WOS:000231774300047