2005年10月
Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis
BIOLOGICAL & PHARMACEUTICAL BULLETIN
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- 巻
- 28
- 号
- 10
- 開始ページ
- 1989
- 終了ページ
- 1991
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/bpb.28.1989
- 出版者・発行元
- PHARMACEUTICAL SOC JAPAN
To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), beta-funaltrexamine (beta-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (kappa-receptor antagonist) and FNA (mu-receptor antagonist), while NTI (delta-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of mu-, kappa-receptors and adenosine-receptor.
- リンク情報
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- DOI
- https://doi.org/10.1248/bpb.28.1989
- CiNii Articles
- http://ci.nii.ac.jp/naid/110003666380
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16204962
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000232680800035&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1248/bpb.28.1989
- ISSN : 0918-6158
- CiNii Articles ID : 110003666380
- PubMed ID : 16204962
- Web of Science ID : WOS:000232680800035