論文

査読有り
2006年12月

Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension

CLINICA CHIMICA ACTA
  • Hyohun Park
  • ,
  • Goji Hasegawa
  • ,
  • Hiroshi Obayashi
  • ,
  • Aya Fujinami
  • ,
  • Mitsuhiro Ohta
  • ,
  • Hirokazu Hara
  • ,
  • Tetsuo Adachi
  • ,
  • Shoko Tamaki
  • ,
  • Yoshiki Nakajima
  • ,
  • Fumiaki Kimura
  • ,
  • Masakazu Ogata
  • ,
  • Michiaki Fukui
  • ,
  • Toshikazu Yoshikawa
  • ,
  • Naoto Nakamura

374
1-2
開始ページ
129
終了ページ
134
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cca.2006.06.004
出版者・発行元
ELSEVIER SCIENCE BV

Background: It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance.
Methods: We investigated the relationship between the homeostasis model assessment-insulin resistance index (HOMA-R) and various serum inflammatory markers and the effect of losartan on serum concentrations of these markers in patients with type 2 diabetes and hypertension. The patients were divided into 2 groups according to the value of HOMA-R with 60 patients with values=2.4 in Group A and 44 patients with values > 2.5 in Group B. The variables were measured at baseline and after 6 months of treatment with losartan (50 mg/day).
Results: The HOMA-R concentrations were positively related to TNF-alpha (r=0.336, P < 0.01) and inversely related to adiponectin (r=-0.405, P < 0.01) and extracellular-superoxide dismutase (EC-SOD) (r=-0.452, P < 0.01). Stepwise multiple regression analysis showed a significant relationship between HOMA-R. and adiponectin (F=8.74) and EC-SOD (F=14.39). In Group B, losartan treatment significantly increased the serum concentrations of EC-SOD and adiponectin and decreased TNF-a and HOMA-R.
Conclusion: Serum EC-SOD concentrations may be a sensitive biochemical marker of insulin resistance in patients with type 2 diabetes and hypertension and that losartan improves insulin sensitivity by increasing EC-SOD and adiponectin production and decreasing TNF-alpha production. (c) 2006 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 14

リンク情報
DOI
https://doi.org/10.1016/j.cca.2006.06.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16857181
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000242040100017&DestApp=WOS_CPL