論文

査読有り
2010年7月

Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells

FASEB JOURNAL
  • Yuta Mizuno
  • Hsi Chang
  • Katsutsugu Umeda
  • Akira Niwa
  • Toru Iwasa
  • Tomonari Awaya
  • So-ichiro Fukada
  • Hiroshi Yamamoto
  • Shinya Yamanaka
  • Tatsutoshi Nakahata
  • Toshio Heike
  • 全て表示

24
7
開始ページ
2245
終了ページ
2253
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1096/fj.09-137174
出版者・発行元
FEDERATION AMER SOC EXP BIOL

Induced pluripotent stem (iPS) cells, which are a type of pluripotent stem cell generated from reprogrammed somatic cells, are expected to have potential for patient-oriented disease investigation, drug screening, toxicity tests, and transplantation therapies. Here, we demonstrated that murine iPS cells have the potential to develop in vitro into skeletal muscle stem/progenitor cells, which are almost equivalent to murine embryonic stem cells. Cells with strong in vitro myogenic potential effectively were enriched by fluorescence-activated cell sorting using the anti-satellite cell antibody SM/C-2.6. Furthermore, on transplantation into mdx mice, SM/C-2.6(+) cells exerted sustained myogenic lineage differentiation in injured muscles, while providing long-lived muscle stem cell support. Our data suggest that iPS cells have the potential to be used in clinical treatment of muscular dystrophies.-Mizuno, Y., Chang, H., Umeda, K., Niwa, A., Iwasa, T., Awaya, T., Fukada, S., Yamamoto, H., Yamanaka, S., Nakahata, T., Heike, T. Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. FASEB J. 24, 2245-2253 (2010). www.fasebj.org

リンク情報
DOI
https://doi.org/10.1096/fj.09-137174
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279343600011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1096/fj.09-137174
  • ISSN : 0892-6638
  • Web of Science ID : WOS:000279343600011

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