大西健 (Ken Ohnishi) - マイポータル

基本情報

所属: 茨城県立医療大学保健医療学部人間科学センター教授

学位: 理学修士(岡山大学)
博士(理学)(岡山大学)

J-GLOBAL ID: 200901044947590583
researchmap会員ID: 1000261406

研究キーワード

研究分野

経歴

1999年 - 2010年

奈良県立医科大学准教授
2010年

- 茨城県立医療大学教授
1998年 - 1999年

奈良県立医科大学講師
1998年 - 1999年

奈良県立医科大学
1999年

- Nara Medical University, Associate Professor
1982年 - 1998年

奈良県立医科大学助手
1982年 - 1998年

奈良県立医科大学

学歴

受賞

論文

The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer

Noriko Nozawa-Suzuki, Hideko Nagasawa, Ken Ohnishi, Ken-ichirou Morishige

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 457(4) 706-711 2015年2月査読有り
Plastic induction of CD133(AC133)-positive cells in the microenvironment of glioblastoma spheroids

Ken Ohnishi, Toshiaki Tani, Shin-Ichi Bando, Nobuo Kubota, Yoshihiro Fujii, Osamu Hatano, Hirosi Harada

INTERNATIONAL JOURNAL OF ONCOLOGY 45(2) 581-586 2014年8月査読有り
Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71

Tatsuya Segawa, Yoshihiro Fujii, Aya Tanaka, Shin-Ichi Bando, Ryuichi Okayasu, Ken Ohnishi, Nobuo Kubota

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 33(3) 559-564 2014年3月査読有り
植物由来天然生理活性物質フィトケミカルの放射線増感作用

坂東真一, 秦野修, 窪田宜夫, 大西健

放射線生物研究 47(2) 193-210 2012年査読有り
Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis

Maki Ohara, Shinichi Kimura, Aya Tanaka, Ken Ohnishi, Ryuichi Okayasu, Nobuo Kubota

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 28(6) 1043-1047 2011年12月査読有り
Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy

Yusei Fujita, Naofumi Yamamoto, Itsuro Kato, Soichi Iwai, Koji Ono, Yoshinori Sakurai, Ken Ohnishi, Takeo Ohnishi, Yoshiaki Yura

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 87(3) 293-301 2011年3月査読有り
Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage

Taichi Noda, Akihisa Takahashi, Natsuko Kondo, Eiichiro Mori, Noritomo Okamoto, Yosuke Nakagawa, Ken Ohnishi, Malgorzata Z. Zdzienicka, Larry H. Thompson, Thomas Helleday, Hideo Asada, Takeo Ohnishi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 404(1) 206-210 2011年1月査読有り
siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells

Noritomo Okamoto, Akihisa Takahashi, Ichiro Ota, Ken Ohnishi, Eiichiro Mori, Natsuko Kondo, Taichi Noda, Yosuke Nakagawa, Hirokazu Uemura, Katunari Yane, Hiroshi Hosoi, Takeo Ohnishi

INTERNATIONAL JOURNAL OF HYPERTHERMIA 27(3) 297-304 2011年査読有り
Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status

Yoko Nagata, Akihisa Takahashi, Ken Ohnishi, Ichiro Ota, Takeo Ohnishi, Takashi Tojo, Shigeki Taniguchi

INTERNATIONAL JOURNAL OF ONCOLOGY 37(4) 1001-1010 2010年10月査読有り
DNA ligase IV is a potential molecular target in ACNU sensitivity

Natsuko Kondo, Akihisa Takahashi, Eiichiro Mori, Taichi Noda, Xiaoming Su, Ken Ohnishi, Peter J. McKinnon, Toshisuke Sakaki, Hiroyuki Nakase, Koji Ono, Takeo Ohnishi

CANCER SCIENCE 101(8) 1881-1885 2010年8月査読有り
ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating

Akihisa Takahashi, Eiichiro Mori, Xiaoming Su, Yosuke Nakagawa, Noritomo Okamoto, Hirokazu Uemura, Natsuko Kondo, Taichi Noda, Atsushi Toki, Yosuke Ejima, David J. Chen, Ken Ohnishi, Takeo Ohnishi

JOURNAL OF RADIATION RESEARCH 51(4) 417-422 2010年7月査読有り
BIPHASIC EFFECTS OF NITRIC OXIDE RADICALS ON RADIATION-INDUCED LETHALITY AND CHROMOSOME ABERRATIONS IN HUMAN LUNG CANCER CELLS CARRYING DIFFERENT p53 GENE STATUS

Xiaoming Su, Akhisa Takahashi, Guozhen Guo, Eiichiro Mori, Noritomo Okamoto, Ken Ohnishi, Toshiyasu Iwasaki, Takeo Ohnishi

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 77(2) 559-565 2010年6月査読有り
Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status

Shin-ichiro Masunaga, Keizo Tano, Jun Nakamura, Masami Watanabe, Genro Kashino, Akihisa Takahashi, Hiroki Tanaka, Minoru Suzuki, Ken Ohnishi, Yuko Kinashi, Yong Liu, Takeo Ohnishi, Koji Ono

JOURNAL OF RADIATION RESEARCH 51(1) 27-35 2010年1月査読有り
Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma

Yusei Fujita, Itsuro Kato, Soichi Iwai, Koji Ono, Minoru Suzuki, Yoshinori Sakurai, Ken Ohnishi, Takeo Ohnishi, Yoshiaki Yura

RADIATION ONCOLOGY 4(63) 2009年12月査読有り
DNA ligase IV as a new molecular target for temozolomide

Natsuko Kondo, Akihisa Takahashi, Eiichiro Mori, Ken Ohnishi, Peter J. McKinnon, Toshisuke Sakaki, Hiroyuki Nakase, Takeo Ohnishi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 387(4) 656-660 2009年10月査読有り
DNA Damage Recognition Proteins Localize along Heavy Ion Induced Tracks in the Cell Nucleus

Aklhlsa Takahashi, Nobuhiro Yamakawa, Tadaaki Kirita, Katsunori Omori, Noriaki Ishioka, Yoshiya Furusawa, Eiichiro Mori, Ken Ohnishi, Takeo Ohnishi

JOURNAL OF RADIATION RESEARCH 49(6) 645-652 2008年11月
Time course and spacial distribution of UV effects on human skin in organ culture

Eiichiro Mori, Akihisa Takahashi, Kou Kitagawa, Saki Kakei, Daiki Tsujinaka, Megumi Unno, Shoko Nishikawa, Ken Ohnishi, Mitsuo Hatoko, Norio Murata, Masakatsu Watanabe, Yoshiya Furusawa, Takeo Ohnishi

JOURNAL OF RADIATION RESEARCH 49(3) 269-277 2008年5月
Development of thermotolerance requires interaction between polymerase-β and heat shock proteins.

Takahashi A, Yamakawa N, Mori E, Ohnishi K, Yokota S, Sugo N, Aratani Y, Koyama H, Ohnishi T

Cancer Science 99(5) 973-978 2008年5月
Heat induces gammaH2AX foci formation in mammalian cells. , 656:

Takahashi A, Mori E, Somakos G.I, Ohnishi K, Ohnishi T

Mutation Research 656 88-92 2008年
Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes

Atsuhisa Kajihara, Akihisa Takahashi, Ken Ohnishi, Yuichiro Imai, Nobuhiro Yamakawa, Jun-ichi Yasumoto, Takeo Ohnishi, Tadaaki Kirita

INTERNATIONAL JOURNAL OF HYPERTHERMIA 24(8) 605-612 2008年査読有り

MISC

179

Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP

Ken Ohnishi, Yoko Nagata, Akihisa Takahashi, Shigeki Taniguchi, Takeo Ohnishi

ONCOLOGY REPORTS 20(1) 57-61 2008年7月
High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation

Nobuhiro Yamakawa, Akihisa Takahashi, Eiichiro Mori, Yuichiro Imai, Yoshiya Furusawa, Ken Ohnishi, Tadaaki Kirita, Takeo Ohnishi

CANCER SCIENCE 99(7) 1455-1460 2008年7月
細胞内の情報伝達に対する温熱の影響

大西健

がんの温熱免疫療法 2008年
温熱による情報伝達の変化

大西健

ハイパーサーミア―がん温熱療法ガイドブック― 2008年
Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population

Shin-ichiro Masunaga, Akihisa Takahashi, Ken Ohnishi, Kenji Nagata, Minoru Suzuki, Genro Kashino, Yuko Kinashi, Takeo Ohnishi, Koji Ono

ONCOLOGY REPORTS 18(6) 1589-1596 2007年12月
Heat-induced phosphorylation of NBS1 in human skin fibroblast cells

Ken Ohnishi, Zorica Scuric, David Yau, Robert H. Schiestl, Noritomo Okamoto, Akihisa Takahashi, Takeo Ohnishi

JOURNAL OF CELLULAR BIOCHEMISTRY 99(6) 1642-1650 2006年12月
Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells

Ken Ohnishi, Shinichi Yokota, Akihisa Takahashi, Takeo Ohnishi

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 82(8) 569-575 2006年8月
LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells

Ken Ohnishi, Jun-Ichi Yasumoto, Akihisa Takahashi, Takeo Ohnishi

INTERNATIONAL JOURNAL OF ONCOLOGY 29(1) 249-253 2006年7月
UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis

A Takahashi, N Shibata, S Nishikawa, K Ohnishi, N Ishioka, T Ohnishi

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 5(5) 467-471 2006年
siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independently of p53 status.

Ohnishi K, Scuric Z, Schiestl R.H, Okamoto N, Takahashi A, Ohnishi T

Radiation Research 166(3) 454-462 2006年
修復関連遺伝子を標的としたRNA干渉によるがん細胞の放射線増感

大西健, 大西武雄

癌の臨床 52 41-45 2006年
変異型p53タンパク質に正常機能を回復させるシャペロン分子

大西健, 大西武雄

放射線生物研究 41 99-108 2006年
Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells

SI Masunaga, H Nagasawa, Y Uto, H Hori, K Ohnishi, A Takahashi, T Ohnishi, M Suzuki, K Nagata, Y Kinashi, K Ono

ONCOLOGY REPORTS 14(2) 393-400 2005年8月
Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status

A Takahashi, H Matsumoto, Y Furusawa, K Ohnishi, N Ishioka, T Ohnishi

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 81(8) 581-586 2005年8月
Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis

Y Imai, K Ohnishi, J Yasumoto, A Kajiwara, N Yamakawa, A Takahashi, T Ohnishi, T Kirita

ORAL ONCOLOGY 41(6) 631-636 2005年7月
Evidence for the involvement of double-strand breaks in heat-induced cell killing

A Takahashi, H Matsumoto, K Nagayama, M Kitano, S Hirose, H Tanaka, E Mori, N Yamakawa, J Yasumoto, K Yuki, K Ohnishi, T Ohnishi

CANCER RESEARCH 64(24) 8839-8845 2004年12月
Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene

K Yuki, A Takahashi, Ota, I, K Ohnishi, J Yasumoto, K Yane, H Kanata, N Okamoto, H Hosoi, T Ohnishi

APOPTOSIS 9(6) 853-859 2004年11月
Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations

SI Masunaga, A Takahashi, K Ohnishi, T Ohnishi, K Nagata, M Suzuki, Y Kinashi, K Ono

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 60(2) 570-577 2004年10月
High-let radiation enhanced apoptosis but not necrosis regardless of P53 status

A Takahashi, H Matsumoto, K Yuki, JI Yasumoto, A Kajiwara, M Aoki, Y Furusawa, K Ohnishi, T Ohnishi

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 60(2) 591-597 2004年10月
C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in human mutant p53 cancer cells

K Ohnishi, H Inaba, J Yasumoto, K Yuki, A Takahashi, T Ohnishi

APOPTOSIS 9(5) 591-597 2004年9月

もっとみる

書籍等出版物

細胞内の情報伝達に対する温熱の影響. In: 吉川敏一監修, がんの温熱免疫療法

診断と治療社, 東京 2008年
温熱による情報伝達の変化. In: 日本ハイパーサーミア学会編、ハイパーサーミア―がん温熱療法ガイドブック

毎日健康サロン出版, 大阪 2008年
p53遺伝子を先行指標とする放射線温熱療法のための基礎的研究. In: 加納永一監修、集学的癌治療の研究と臨床

篠原出版新社, 東京 2002年
DNA-PK activity plays a role on radioadaptation for radiation-induced apoptosis. In: Sugawara T, Nikaido O and Niwa O eds. Radiation and Hormeostasis.

Elsevier Science, Amsterdam (Holland) 2001年
Suppression of X-ray-induced apoptosis by low dose pre-irradiation in the spleen of C57BL/6 mice. In: Sugawara T, Nikaido O and Niwa O eds. Radiation and Hormeostasis.

Elsevier Science, Amsterdam (Holland) 2001年
重粒子と温熱併用療法におけるp53遺伝子の意義 In: 辻井博彦編、重粒子線治療の基礎と臨床

医療科学社, 東京 2000年
Heat-induced growth inhibition and apoptosis in transplanted human toungue carcinomas with different p53 gene. In: Tanaka R ed. Advances in Hyperthermic Oncology 2000.

Kosoku Printing Co. Ltd. (Niigata) 2000年
Hyperthermic cancer therapy depending on p53 gene status. In: Tanaka R ed. Advances in Hyperthermic Oncology 2000.

Kosoku Printing Co. Ltd. (Niigata) 2000年
Biological effects of space radiation. In: Majima HJ and Fujitaka K eds. Exploring future research strategies in space radiation sciences.

Iryokagakusha Co. Ltd. (Tokyo) 2000年
Different radiation-induced response of p53 and WAF1 accumulation after chronic or acute radiation. In: Yamada T, Mothersill C, Michael BD and Potten CS eds. Biological effects of low dose radiation.

Elsevier Science, Amsterdam (Holland) 2000年
Radio-adaptive survival response in mice; suppression of p53 accumulation after X-irradiation by small dose pre-irradiation in c57bl/6 mice, In: World Council of Nuclear Workers, Elsevier Science ed. The effects of low and very low doses of ionizing ra・・・

Elsevier Science, Amsterdam (Holland) 2000年
Cell growth, morphology and cell differentiation of Dictyostelium discoideum in space environment. In: Shibata T., Etoh T. eds. Ultra-long-term Cryogenic Preserv.

Network Biol. Environ. Specimens (Tokyo) 1996年
Suppression of heat-induced hsp72 accumulation by the combination of hyperthermia and cisplatin. Arcangeli C.F.G., Cavaliere R. eds. Hyperthermic Oncology.

Postgraduate School of Med. Phys. Tor Vergata Univ. of Rome (Italy) 1996年

大西健

基本情報

研究キーワード

研究分野

経歴

学歴

受賞

論文

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

メニュー