J-GLOBAL         Last updated: Jun 10, 2019 at 07:32
Gunma University
Job title
PhD(Kyoto University)

Research Areas


Academic & Professional Experience

Associate Proffesor: ASRLD Unit, Gunma University
- Gunma University Heavy Ion Medical Center
Lecture: Department of Biology, Nara Medical University
Assistant Proffesor: Department of Biology, Nara Medical University
Otsuka Otsu Research Laboratories


Department of Biology, Faculty of Education, Tokyo Gakugei University
Science of Secondary School Education Course, Faculty of Education, Tokyo Gakugei University

Committee Memberships

PTCOG Radiobiology Sub-committee  Vice President

Awards & Honors

ICRR2015 Excellent Poster Award
Abe Award from Japanese Society of Thermal Medicine
Association Award from International Association for the Sensitization of Cancer Treatment
Young Investigator Award from Radiation Effects Association
Young Investigator Award from Japanese Society of Hyperthermic Oncology
A Foundation of Saichi Nakajima Award from Nara Medical University School of Medicine
Incentive Award from Japanese Association of Radiation Research Society
Young Investigator Award from International Association for the Sensitization of Cancer Treatment
Young Investigator Award from Japanese Association of Space Biology Science

Published Papers

Effects of p53 status of tumor cells and combined treatment with mild hyperthermia, wortmannin or caffeine on recovery from radiation-induced damage
Shin-ichiro Masunaga, Keizo Tano, Yu Sanada, Minoru Suzuki, Akihisa Takahashi, Ken Ohnishi, Koji Ono
the World Journal of Oncology      Jun 2019   [Refereed]
Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation.
Hada M, Ikeda H, Rhone JR, Beitman AJ, Plante I, Souda H, Yoshida Y, Held KD, Fujiwara K, Saganti PB, Takahashi A.
International Journal of Molecular Science   20 43   Dec 2018   [Refereed][Invited]
Temporary loading prevents cancer progression and immune organ atrophy induced by hind-limb unloading in mice
Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y.
International Journal of Molecular Science   19 3959   Dec 2018   [Refereed][Invited]
Yoshida Y, Sejimo Y, Kurachi M, Ishizaki Y, Nakano T, Takahashi A.
Neurochemistry International   119 199-206   Oct 2018   [Refereed]
Heat induces histone γH2AX gormation under hypoxia
Yoshida Y, Tominaga S, Ma L, Takahashi A.
Thermal Medicine   34(3) 45-51   Sep 2018   [Refereed]
Nakagawa Y, Kajihara A, Takahashi A, Murata AS, Matsubayashi M, Ito SS, Ota I, Nakagawa T, Hasegawa M, Kirita T, Ohnishi T, Mori E.
International Journal of Hyperthermia   34(6) 795-801   Sep 2018   [Refereed]
Park SJ, Heo K, Choi C, Yang K, Adachi A, Okada H, Yoshida Y, Ohno T, Nakano T, Takahashi A.
Journal of Radiation Research   58(6) 765-771   Nov 2017   [Refereed]
Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A.
Life Sciences in Space Research   12 51-60   Feb 2017   [Refereed]
Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A.
Biological Science in Space   30 8-16   Dec 2016   [Refereed]
Takahashi A, Mori E, Nakagawa Y, Kajihara A, Kirita T, Pittman DL, Hasegawa M, Ohnishi T.
International Journal of Hyperthermia   33(3) 1-7   Mar 2017   [Refereed]


Role of high-linear energy transfer radiobiology in space radiation exposure risk
Akihisa Takahashi, Hiroko Ikeda, Yukari Yoshida
Int J Part Ther   5(1) 151   Nov 2018   [Refereed][Invited]
Held, Kathryn D.; Kawamura, Hidemasa; Kaminuma, Takuya; Paz, Athena Evalour S.; Yoshida, Yukari; Liu, Qi; Willers, Henning; Takahashi, Akihisa
FRONTIERS IN ONCOLOGY   6 23   2016   [Refereed][Invited]
Ota I, Okamoto N, Yane K, Takahashi A, Masui T, Hosoi H, Ohnishi T
Exp Ther Med   3(4) 585-591   Apr 2012   [Refereed]
Ohnishi T, Takahashi A, Suzuki H, Omori K, Shimazu T, Ishioka N.
Biol Sci Space.   23 3-10   2009   [Refereed]
Matsumoto H, Hamada N, Takahashi A, Kobayashi Y, Ohnishi T.
J Radiat Res   48 97-106   2007   [Refereed]

Books etc

Hyperthermic Oncology from Bench to Bedside (Chapter 9)
Springer   2016   
Hyperthermic Oncology from Bench to Bedside (Chapter 3)
Springer   2016   
Heat-induced DNA Damage (Cellular Response to Physical Stress and Therapeutic Application)
Nova Science Publishers, Inc   2013   
Encyclopedia of Cancer, 2nd Edition.
Springer.   2009   
Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development.
Institute for Environmental Sciences   2002   

Conference Activities & Talks

How to research about simulated space environments on the Earth [Invited]
International Conference on Mechanical, Electrical and Medical Intelligent System 2019 (ICMEMIS2019), Kiryu, Japan   4 Dec 2019   
Is gravity parameter necessary for cancer risk assessment in long-term manned space missions? [Invited]
Akihisa Takahashi
ISRBW2019, Dalian, China   30 Sep 2019   
Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-limb Unloading
Akihisa Takahashi, Shoto Wakihata, Liqiu Ma, Takuya Adachi, Yukari Yoshida, Yoshinobu Ohira
ISTS2019, Fukui, Japan   19 Jun 2019   
Space Experiments for "Cancer Progression" in the International Space Station
Akihisa Takahashi, Masafumi Muratani, Asako Sawano, Atushi Miyawaki
ISGP2019, Nagoya, Japan   26 May 2019   
Gunma University Heavy Ion Medical Center (GHMC): Therapy and Space Research [Invited]
ICTSS2019, Kiryu, Japan   8 May 2019   
Future space experiments for “cancer risk assessment” in the ISS and the Gateway [Invited]
SMME2019, Kiryu, Japan   20 Mar 2019   
Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation.
Rhone JR, Beitman A, Ikeda H, Souda H, Yoshida Y, Held KD, Fujiwara K, Takahashi A, Saganti PB, Hada M.
2019 NASA Human Research Program Investigators' Workshop   Jan 2019   
The synergistic effect of simulated microgravity and charged particle radiation on gene expression in human fibroblasts.
Ikeda H, Muratani M, Puspitasari A, Held KD, Hidema J, Yoshida Y, *Takahashi A.
42nd COSPAR   Jul 2018   
Heat induces DNA double strand breaks under hypoxia
The 7th Asian Congress of Hyperthermic Oncology   2018   
Anti-tumor and anti-metastasis effects of carbon-ion radiotherapy combined with anti-CTLA4 antibody
PTCOG57   2018   

Research Grants & Projects

Acute Effects of Space Radiation with Different Radiation Qualities and Dose-rates
Project Year: 2015 - 2019    Investigator(s): 髙橋昭久 群馬大学, 重粒子線医学推進機構, 教授 (60275336)
Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer
Project Year: 2014 - 2016    Investigator(s): 太田 一郎 奈良県立医科大学, 医学部, 講師 (00326323)
Selection of DSBs repair pathways in heat-induced cell death mediated by BRCA2
Project Year: 2014 - 2016    Investigator(s): 梶原 淳久 奈良県立医科大学, 医学部, 研究員 (00382317)
Elucidation of molecular mechanisms for radiation-induced cellular responses
JST Target Oriented Research for Embryonic Science and Technology (TOREST)
Project Year: 2011 - 2015
Biological effect of space radiation
Grant-in-Aid for Scientific Research
Project Year: 2015