FUJIMURA Yoshihiro

J-GLOBAL         Last updated: Nov 14, 2012 at 10:22
FUJIMURA Yoshihiro
Nara Medical University
Nara Medical University Hospital, Central Clinical Facilities, Department of Blood Transfusion Medicine
Doctor(Medicine)(Nara Medical University)

Research Areas


Academic & Professional Experience

Oct 1998
Professor, Dep. of Blood Transfusion Medicine, Nara Medical University
Jan 1988
Sep 1998
Associate Professor, Dep. of Blood Transfusion Medicine,Nara Medical University
Jan 1987
Dec 1987
Assistant Professor, Dep. of Blood Transfusion Medicine, Nara Medical University
Jan 1984
Dec 1986
Research Associate, Scripps Clinic and Research Foundation
May 1978
Dec 1983
Dep. of Pediatrics, Nara Medical University
May 1978
Dec 1983
Assistant Professor, Dep. of Pediatrics,Nara Medical University
Jan 1974
Apr 1978
Physician of Pediatric Clinic, Osaka National Hospital
May 1973
Dec 1973
Physician of Pediatric Clinic, Nara Medical University
Research Associate
Nara Medical Nniv. Tecchiy Staff


Faculty of Medicine, Nara Medical University

Committee Memberships

Japan Transfusion Society, Kinki District  President

Awards & Honors

Erwin von Belz prize

Published Papers

Miyata T,Kokame K, Matsumoto M, Fujimura Y.
Hӓmostaseologie (in press)      2012   [Refereed]
Tanabe S, Yagi H, Kimura T, Isonishi A, Kato S, Yoshida Y, Hayakawa M, Matsumoto M, Ohtaki S, Takahashi Y, Fujimura Y
Int J Hematol (in press)   96(6) 789   2012   [Refereed]
Yamamoto-Suzuki Y, Sakurai Y, Fujimura Y, Matsumoto M, Hamako J, Kokubo T, Kitagawa H, Kawsar SM, Fujii Y, Ozeki Y, Matsushita F, Matsui T
Biochemistry USA   51(26) 5329-5338   2012   [Refereed]
Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y
Atherosclerosis (in press)   224(2) 511-514   2012   [Refereed]
Yagi H, Yamaguchi N, Shida Y, Hayakawa M, Matsumoto M, Sugimoto M, Wada H, Tsubaki K, Fujimura Y.
Eur J Pharmacol   691(1-3) 151-155   2012   [Refereed]
Platelet-derived microparticles in patients with arteriosclerosis obliterans: Enhancement of high shear-induced microparticle generation by cytokines
98 257-260   2000   [Refereed]
Activation of protein-tyrosine kinase pathways in human platelets stimulated with the A1 domain of von Willebrand factor
Platelets   11 171-176   2000   [Refereed]
The interaction of botrocetin with normal or variant von Willebrand factor ( typesⅡA and ⅡB ) and its inhibition by monoclonal antibodies that block receptor binding
Thromb Haemost   68 464-469   1992   [Refereed]
Studies on anti-von Willebrand factor (vWF) monoclonal antibody NMC-4 which inhibits both ristocetin- and botrocetin-induced vWF binding to platelet glycoprotein lb
Blood   77 113-120   1991   [Refereed]
Biochem Biophys Res Commun   178(3) 1253-1259   1991   [Refereed]
Flow cytometric analysis of platelet antibodies specific to the surface membrane components in patients with chronic ITP using acid treated, fomalin-fixed platelets
Am J Hematol   37 274-276   1991   [Refereed]
Anti-platelet glycoprotein lb monoclonal antibody (OP-F1) totally abolishes ristocetin-induced von Willebrand factor binding, but has minimal effect on the botrocetin-induced binding
Haemostasis   21 353-359   1991   [Refereed]
Enhanced botrocetin-induced type ⅡB von Willebrand factor binding to platelet glycoprotein lb initiates hyperagglutination of normal platelets
Am J Hematol   33 261-266   1990   [Refereed]
Enhanced ristocetin-induced von Willebrand factor binding to platelet glycoprotein lb in patients with steroid-responsive nephrotic syndrome
Haemostasis   20 219-228   1990   [Refereed]
Heparin-associated thrombocytopenia:observations on the mechanism of platelet aggregation
J Lab Clin Med   113 204-210   1989   [Refereed]
Spontaneous platelet aggregation in type ⅡB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPlb binding domain
Am J Hematol   30 150-153   1989   [Refereed]
Blood clotting factor Ⅸ Kashihara: aminoacid substitution of valine-182 by phenylalanine
J Biochem   105 756-759   1989   [Refereed]
Structure of the von Willebrand factor domain interacting with glycoprotein lb
J Biol Chem   263 17901-17904   1988   [Refereed]
Epitope mapping of the von Willebrand factor subunit distinguishes fragments present in normal and type ⅡA von Willebrand disease from those generated by plasmin
J Clin Invest   79 524-531   1987   [Refereed]
A heparin-binding domain of human von Willebrand factor. Characterization and localization to a trypticfragment extending from amino acid residue Val-449 to Lys-728
J Biol Chem   262 1734-1739   1987   [Refereed]
The von Willebrand factor domain mediating botrocetin-induced binding to glycoprotein lb lies between Val449 and Lys728
Blood   70 985-988   1987   [Refereed]
von Willebrand factor:A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein lb
J Biol Chem   261 381-385   1986   [Refereed]
Isolation and characterization of a collagen binding domain in human von Willebrand factor
J BIol Chem   261 15310-15315   1986   [Refereed]
von Willebrand factor. A reduced and alkylated 52/48kDa-fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib.
J. Biol. Chem.   261 381-385   1986
Separation of an active substance responsible for the factor Ⅷ -inhibior bypassing activity in Autoplex
Acta Haematol Jap   48 136-146   1985   [Refereed]
Immunoassays of factor Ⅸantigen using monoclonal antibodies
Br J Haematol   59 265-275   1985   [Refereed]
Enzyme immunoassay of α1-plasmin inhibitor
Acta Haematol Jap   47 158-163   1984   [Refereed]
Removal of a calcaneus pseudotumor in a factor Ⅷ deficient patient with inhibitor using Autoplex
J Nara Med Assoc   35 291-297   1984   [Refereed]
Purification of human coagulation factor X and the immunochemical studies of factor X antigen in patients with congenital or acquired factor X deficiency
J Nara Med Assoc   35 138-148   1984   [Refereed]
Studies on precursor proteins PIVKA-Ⅱ, -Ⅸ,and -Ⅹ in the plasma of patients with 'Hemorrhagic disease of the newborn'
Haemostasis   14 211-217   1984   [Refereed]
Congenital hypoprothrombinemia: the first reported case in Japan
Acta Paed Jap   26 554-560   1984   [Refereed]
Haemophilia B⁻in agirl
Clin Lab Haematol   4 405-410   1982   [Refereed]
Abnormal antigens of factors Ⅱ,Ⅶ and Ⅸ in newborns and breast-fed infants with vitamin K deficiency
Acta Haematol Jap   45 196-202   1982   [Refereed]
Yoshihiro FUJIMURA, Toshiyuki SAKAI, Ikuko MATSUYAMA, Sadaaki MIKAMI, Akira YOSHIOKA, Hiromu FUKUI
Blood Vessel   13(1) 63-71   1982   [Refereed]
Studies on vitamin K-dependent factor deficiency during early childhood with special reference to prothrombin activity and antigen level
Haemostasis   11 90-95   1982   [Refereed]
Partial proteolytic susceptibility to contact activation in hemophilia B⁺ with slightly prolonged bovine brain prothrombin time
J Nara Med Assoc   32 526-536   1981   [Refereed]
Laboratory evidence of DIC under FEIBA treatment of a hemophilic patient with intracranial bleeding and high-titer factor Ⅷ inhibitor
Thromb Res   22 177-184   1981   [Refereed]
Patterns of factor-Ⅷ related antigen on crossed immunoelectrophoresis and large porepolyacrylamide gel-crossed immunoelectophoresisin von Willebrand's disease
Br J Haematol   46 269-276   1980   [Refereed]
Studies on factor Ⅷ procoagulant activity (Ⅷ:C): its purification and some biochemical properties
J Nara Med Assoc   30 199-212   1979   [Refereed]
Pathophysiology of von Willebrand's disease : qualitative and quantitative analysis of von Willebrand protein
Acta Hematol Jap   41 839-850   1979   [Refereed]
A note on the carrier detection of Hemophilia A
Jap Human Genet   22 261-270   1977   [Refereed]


Jacob S, Dunn BL, Qureshi ZP, Bandarenko N, Kwaan HC, Pandey DK, McKoy JM,Barnato SE, Winters JL, Cursio JF, Weiss I, Raife TJ, Carey PM, Sarode R, Kiss JE, Danielson C, Ortel TL, Clark WF, Rock G, Matsumoto M, Fujimura Y, Zheng XL, Chen H, Chen F, Armstrong JM, Raisch DW, Bennett CL.
Semin Thromb Hemost (in press).      2012   [Refereed]

Books etc

Thrombotic microangiopathy. Recent Advances in THrombosis and Hemostasis2008
Fujimura Y, Matsumoto M, Yagi H
Springer-Verlag   2007   
FUJIMURA Yoshihiro
Int J Hematol (Education Program Book)   2003   
Structure and function of human von Willebrand factor : Coagulation and Bleeding Disorders
Fujimura Y, Ruggeri ZM, Zimmerman TS
Marcel Dekker Inc(New York and Basel)   1989   
Hemostasis and Thrombosis : Structure and function of von Willebrand factor.
Fujimura Y, Titani K.
Churchill-Livingstone(London)   1994   

Research Grants & Projects

Mechanism of platelet thrombi formation
Thrombotic microangiopathy