2010年7月
The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons
FEBS LETTERS
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- 巻
- 584
- 号
- 13
- 開始ページ
- 2801
- 終了ページ
- 2806
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.febslet.2010.05.020
- 出版者・発行元
- ELSEVIER SCIENCE BV
The small GTPase ADP-ribosylation factor 6 (ARF6) plays crucial roles in a wide variety of cell functions. To better understand the molecular mechanisms of ARF6-mediated signaling and cellular functions, we sought new ARF6-binding proteins in the mouse brain. We identified the signaling scaffold protein JNK-interacting protein 3 (JIP3), which is exclusively expressed in neurons, as a downstream effector of ARF6. Overexpression of a unique dominant negative mutant of ARF6, which was unable to interact with JIP3, and knockdown of JIP3 in mouse cortical neurons stimulated the elongation and branching of neurites. These results provide evidence that ARF6/JIP3 signaling regulates neurite morphogenesis.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.febslet.2010.05.020
- CiNii Articles
- http://ci.nii.ac.jp/naid/120002233499
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20493856
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000278657200014&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.febslet.2010.05.020
- ISSN : 0014-5793
- CiNii Articles ID : 120002233499
- PubMed ID : 20493856
- Web of Science ID : WOS:000278657200014