論文

査読有り
2010年7月

The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons

FEBS LETTERS
  • Atsushi Suzuki
  • ,
  • Chihiro Arikawa
  • ,
  • Yuji Kuwahara
  • ,
  • Kouichi Itoh
  • ,
  • Masatomo Watanabe
  • ,
  • Hiroshi Watanabe
  • ,
  • Teruhiko Suzuki
  • ,
  • Yuji Funakoshi
  • ,
  • Hiroshi Hasegawa
  • ,
  • Yasunori Kanaho

584
13
開始ページ
2801
終了ページ
2806
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.febslet.2010.05.020
出版者・発行元
ELSEVIER SCIENCE BV

The small GTPase ADP-ribosylation factor 6 (ARF6) plays crucial roles in a wide variety of cell functions. To better understand the molecular mechanisms of ARF6-mediated signaling and cellular functions, we sought new ARF6-binding proteins in the mouse brain. We identified the signaling scaffold protein JNK-interacting protein 3 (JIP3), which is exclusively expressed in neurons, as a downstream effector of ARF6. Overexpression of a unique dominant negative mutant of ARF6, which was unable to interact with JIP3, and knockdown of JIP3 in mouse cortical neurons stimulated the elongation and branching of neurites. These results provide evidence that ARF6/JIP3 signaling regulates neurite morphogenesis.

リンク情報
DOI
https://doi.org/10.1016/j.febslet.2010.05.020
CiNii Articles
http://ci.nii.ac.jp/naid/120002233499
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20493856
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000278657200014&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.febslet.2010.05.020
  • ISSN : 0014-5793
  • CiNii Articles ID : 120002233499
  • PubMed ID : 20493856
  • Web of Science ID : WOS:000278657200014

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