Akihiko Hatano

Profile Information

Affiliation: Prof. (Ph.D (Science)), College of Engineering, Materials Science and Engineering, Shibaura Institute of Technology

Degree: (BLANK)(Mar, 1994, Tokyo Institute of Technology)
Dr. of Science(Sep, 2000, The Graduate University for Advanced Studies)

J-GLOBAL ID: 200901010064155044
researchmap Member ID: 1000263390

External link: https://www.a-hatano-lab.com/

生体分子である核酸やタンパク質を利用した化学を推進しています。生物を化学的側面から観察して，有機化学的な技術により，不可能であったことを可能にする突破口を見つけるような研究を進めています。

・核酸へ非天然ヌクレオシドを導入したときの構造と機能

・核酸代謝酵素を利用した非天然ヌクレオシドの合成

・血管新生因子を検出する蛍光プローブの開発

・有機小分子を利用した細胞識別法の開発

Research Interests

Research Areas

Research History

Apr, 2014 - Present

College of Engineering, Shibaura Institute of Technology
Apr, 2008 - Mar, 2014

College of Engineering, Shibaura Institute of Technology
Oct, 2000 - Apr, 2008

Faculty of Science and Technology, Shizuoka Institute of Science and Technology
1999 - 2000

日本学術振興会特別研究員
1999 - 2000

JSPS Research Fellowships
1994 - 1997

Research and Development Center, Unitika Ltd.
1994 - 1997

Unitika Ltd. R & D

Education

Committee Memberships

Apr, 2019 - Mar, 2022

化学クラブ実行委員, 日本化学会関東支部
2002

トピックス編集委員, 日本化学会

Awards

2005

ITE award
2002

有機合成化学協会研究企画賞（第一製薬）

Papers

Chemoenzymatic synthesis of unnatural nucleoside with stable isotopes

Genki SHIMANE, Nanae Terado, Akihiko HATANO

3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development, 2023, P28, Sep, 2023 Peer-reviewedCorresponding author
Synthesis of pentostatin precursor with pyrimidine nucleoside phosphorylase

Rai Hamano, Akihiko Hatano, Riki Matsuzaka

3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development, 2023, P24, Sep, 2023 Peer-reviewedCorresponding author
Introduction of pseudo-base benzimidazole derivatives into nucleosides via base exchange by a nucleoside metabolic enzyme

Akihiko Hatano, Riki Matsuzaka, Genki Shimane, Hiroyuki Wakana, Kou Suzuki, Chisato Nishioka, Aoi Kojima, Masatoshi Kidowaki

Bioorganic & Medicinal Chemistry, (91) 117411-117411, Jul, 2023 Peer-reviewedLead author
Supramolecular Conjugation between 18-Crown 6-Ether and Tannic Acid with Unique pH Responsiveness

Saki Endo, Mahiro Sarai, Akihiko Hatano, Kenichi Niikura

Chemistry Letters, May 10, 2023 Peer-reviewed
Effects of Functional Groups Recognition of Nucleoside Structure for Phosphorolysis with Pyrimidine Nucleoside Phosphorylase PyNP

Rei HAMANO, Koichi OTSUKIi, Akihiko HATANO

SEATUC 2023, Mar, 2023 Peer-reviewedLast authorCorresponding author
Introduction of Benzimidazole as Purine Analog into Nucleoside Structure by Base-Exchange Reaction of Nucleoside Metabolism Enzyme

Riki MATSUSAKA, Akihiko HATANO

SEATUC 2023, Mar, 2023 Peer-reviewedLast authorCorresponding author
Development of the one-dimensional integrated inhibitor of deoxynojirimycin using DNA sequences

Ryu MAYUMI, Akihiko HATANO

SEATUC 2023, Mar, 2023 Peer-reviewedLast authorCorresponding author
Synthesis of spin-labeled RNAs to elucidate the function of reverse transcriptase

Nagihiro Miyahara, Nanae Terado, Saki Kaneko, Akihiko Hatano

SEATUC 2023, Mar, 2023 Peer-reviewedLast authorCorresponding author
Examination of chemical enzyme synthesis method to introduce multiple stable isotopes into nucleoside molecular structure

Genki SHIMANE, Akihiko HATANO, Nanae TERADO

SEATUC 2023, Mar, 2023 Peer-reviewedLast author
Effects of Functional Groups Recognition of Nucleoside substrate for Phosphorolysis with Nucleoside Metabolic Enzyme PyNP

Ryu MAYUMI, Koichi OTSUKI, Akihiko HATANO

Active Enzyme Molecules, Sep, 2022 Peer-reviewedLast author
, Base Exchange Effects of Benzimidazole as Pseudo Purine Base into Nucleoside Structure with Nucleoside Metabolic Enzyme

Riki MATSUSAKA, Takumi HAYASHIDA, Akihiko HATANO

Active Enzyme Molecules, p01, Sep, 2022 Peer-reviewed
Examination of chemical enzyme synthesis method to introduce multiple stable isotopes into uridine molecular structure,

Genki SHIMANE, Akihiko HATANO

Active Enzyme Molecules, 8, Sep, 2022 Last author
Reagentless Sensing of Vancomycin Using an Indium Tin Oxide Electrode Grafted with Molecularly Imprinted Polymer including Ferrocenyl Group

Haruto Eguchi, Akihiko Hatano, Yasuo Yoshimi

Sensors, 21(24) 8338-8338, Dec 13, 2021 Peer-reviewedLast author
A single-use ceramic-based electrochemical sensor chip using molecularly imprinted carbon paste electrode

Aaryashree, Takeda, Yuuto, Kanai, Momoe, Hatano, Akihiko, Yoshimi, Yasuo, Kida, Masahito

Sensors, 20(20) 5847, 2020 Peer-reviewed
Parallel motif triplex formation via a new, bi-directional hydrogen bonding pattern incorporating a synthetic cyanuryl nucleoside into the sense chain

Akihiko Hatano, Kei Shimazaki, Maina Otsu, Gota Kawai

RSC Advances, 10(38) 22766-22774, 2020
Use of a deoxynojirimycin–fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes

Akihiko Hatano, Yuichi Kanno, Yuya Kondo, Yuta Sunaga, Hatsumi Umezawa, Koji Fukui

Bioorganic & Medicinal Chemistry, 27(5) 859-864, Mar, 2019
A conventional and solid-state synthesis, biological activity, and molecular docking studies of 6-arylbenzo[4,5]imidazo[1,2-a] [1,8]naphthyridin-10-ols

Sakram Boda, Ravi Dharavath, Madhavi Madhavaram, Kurumanna Adem, Madhu Palithapu, Govan Maloth, Parthasarathy T

Synthetic Communications, 49(1) 1-11, Jan 2, 2019
Effects of;bloo;components on;vancomycin sensing;by molecularly imprinted polymer-fixed indium tin;oxide electrode

H. Eguchi, A. Hatano, Y. Yoshimi

Chemical Sensors, 35 109-111, 2019 Peer-reviewed
Bio-catalytic synthesis of unnatural nucleosides possessing a large functional group such as a fluorescent molecule by purine nucleoside phosphorylase

Akihiko Hatano, Hiroyuki Wakana, Nanae Terado, Aoi Kojima, Chisato Nishioka, Yu Iizuka, Takuya Imaizumi, Sanae Uehara

Catalysis Science & Technology, 9(18) 5122-5129, 2019
Synthesis of unnatural nucleosides containing fluorescent group by using nucleic acid metabolic enzyme

H. Wakana, N. Terado, A. Hatano

15th Japan-China-Korea Joint Symposium on Enzyme Engineering, p12, Jun, 2018 Peer-reviewedLast author

Misc.

Fragmentation of cyclopropanol systems

The Bulletin of the Shizuoka Institute of Science and Technology, 15 105-115, 2007
Deprotection of dithioacetals using the tantalum(V) chloride catalyzed oxidation of iodide ion by hydrogen peroxide

M Kirihara, A Harano, H Tsukiji, R Takizawa, T Uchiyama, A Hatano

TETRAHEDRON LETTERS, 46(37) 6377-6380, Sep, 2005
Fragmentation of tertiary cyclopropanol compounds catalyzed by vanadyl acetylacetonate

M Kirihara, H Kakuda, M Ichinose, Y Ochiai, S Takizawa, A Mokuya, K Okubo, A Hatano, M Shiro

TETRAHEDRON, 61(20) 4831-4839, May, 2005
Synthesis and redox-active base-pairing properties of DNA incorporating mercapto C-nucleosides

A Hatano, S Makita, M Kirihara

TETRAHEDRON, 61(7) 1723-1730, Feb, 2005
タンタル触媒-過酸化水素によるヨウ素陰イオンのヨウ素陽イオン等価体への酸化反応:ヨードラクトン化への応用

桐原正之, 大久保久美子, 幡野明彦

静岡理工科大学紀要, 13 65-67, 2005
Aerobic oxidation of thiols to disulfides catalyzed by trichlorooxyvanadium

M Kirihara, K Okubo, T Uchiyama, Y Kato, Y Ochiai, S Matsushita, A Hatano, K Kanamori

CHEMICAL & PHARMACEUTICAL BULLETIN, 52(5) 625-627, May, 2004
Aerobic oxidation of thiols to disulfides catalyzed by trichlorooxyvanadium

M Kirihara, K Okubo, T Uchiyama, Y Kato, Y Ochiai, S Matsushita, A Hatano, K Kanamori

CHEMICAL & PHARMACEUTICAL BULLETIN, 52(5) 625-627, May, 2004
Synthesis and characterization of mercapto C-nucleoside forming disulfide bonding incorporated into DNA

Bioorg. Med. Chem. Lett., 10, 2459-2462, 2004
Electrophilic Brominations of Organic Compounds by Employing Tantalum(V) Catalyzed Oxidation of Bromide Ion by Hydrogen Peroxide

ITE Lett., 5, 279-281, 2004
Reaction of tertiary cyclopropyl silyl ethers with diethylaminosulfur trifluoride: the effects of substituents on the cleavage of the cyclopropane ring

M Kirihara, H Kakuda, M Tsunooka, A Shimajiri, T Takuwa, A Hatano

TETRAHEDRON LETTERS, 44(46) 8513-8518, Nov, 2003
Nematic ordering behavior in stretched fiber of a lipid-poly L-glutamic acid complex

ITE Letters, 4, 220-223, 2003., 2003
DNA Molecular Beacon によるポリメラーゼ反応のモニタリングと遺伝子診断

化学と工業, 56, 488, 2003, 2003
Syntheses of nucleic acid mimics designed for metal-induced strand formation on DNA

A Hatano, K Tanaka, M Shiro, M Shionoya

TETRAHEDRON, 58(15) 2965-2972, Apr, 2002
Fe(acac)3 catalyzed trimethylsilylation of alcohols with trimethylsilyl azide,

ITE Letters, 3, 225-227, 2002
Syntheses of metal ion-induced nucleic acid mimics each containing four nucleohases and interaction with single-stranded DNA

Tetrahedron, 2001
Self-assembly of chelator-type nucleic acid mimics into a single-stranded Zn-II coordination polymer

A Hatano, K Tanaka, M Shiro, M Shionoya

CHEMISTRY LETTERS, (7) 822-823, Jul, 2000
Metal-Assisted Formation of Artificial Nucleic Acids

Nucleic Acids Symp.Ser., 39, 171-172, 1998
Metal-assisted formation of art ifitial nucliec acids

Nucleic Acids Symposium Series, (39) 171, 1998
インプリント手法を用いる脂質修飾リパーゼの不斉選択性の改変

6(6) 1311, 1995
Enhancing enantioselectivity of a lipid-coated lipase via imprinting methods for esterification in organic solvents

Yoshio Okahata, Akihiko Hatano, Kuniharu Ijiro

Tetrahedron: Asymmetry, 6(6) 1311-1322, 1995

Professional Memberships

Works

Research Projects

血管新生因子をターゲットとした癌細胞特異的蛍光プローブの開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

幡野明彦, 福井浩二
Cancer cell-specific imaging with the fluorescent probe responding by thymidine phosphorylase

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Hatano Akihiko
Synthesis of the variety nucleostide probes produced by synchronization of the biocatalyst and the palladium catalyst

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

HATANO Akihiko
人工核酸を用いた細胞内レドックス環境のセンシングとイメージング

日本私立学校振興・共催事業団平成26年度学術研究振興資金, 私学助成, Apr, 2014 - Mar, 2015
核酸代謝酵素を利用した安定同位体導入ヌクレオシドの効率的合成

産学が連携した研究開発成果の展開研究成果展開事業研究成果最適展開支援プログラム(A-STEP) 探索タイプ, 2012 - 2013

幡野明彦
核酸転移酵素の機能解明と阻害剤の開発

2004
金属イオンにより誘起される人工DNAの自発的集合化

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 1999 - 2000

幡野明彦
非天然核酸合成
脂質を用いたペプチに分子の機能化
非天然アミノ酸を利用した金属イオンの集積化
金属配位結合で二重鎖を形成する人工DNA
Functinalization of the peptids by lipid modifications
The accumulation of the metal ion by mean of artificial amino acids
Metal-anisted formation of artificial nucleic acids

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Research History

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Misc.

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