Research Associate, Department of Medical Microbiology and Immunology,College of Medicine (Dr.Herman Friedman, Dr. Julie Djeu), University of South Florida, USA
Kuwahara T, Hazama S, Suzuki N, Yoshida S, Tomochika S, Nakagami Y, Matsui H, Shindo Y, Kanekiyo S, Tokumitsu Y, Iida M, Tsunedomi R, Takeda S, Yoshino S, Okayama N, Suehiro Y, Yamasaki T, Fujita T, Kawakami Y, Ueno T, Nagano H.
Matsuda T,Takeuchi H, Sakurai T, Mayanagi S, Booka E, Fujita T, Higuchi H, Taguchi J, Hamamoto Y, Takaishi H, Kawakubo H, Okamoto M, Sunamura M, Kawakami Y, Kitagawa Y.
Kanekiyo S, Hazama S, Takenouchi H, Nakajima M, Shindo Y, Matsui H, Tokumitsu Y, Tomochika S, Tsunedomi R, Tokuhisa Y, Iida M, Sakamoto K, Suzuki N, Takeda S, Yamamoto S, Yoshino S, Okuno K, Udaka K, Kawakami Y, Matsueda S, Ito K, Nagano H.
Franck Pagès, Bernhard Mlecnik, Florence Marliot, Gabriela Bindea, Fang-Shu Ou, Carlo Bifulco, Alessandro Lugli, Inti Zlobec, Tilman T. Rau, Martin D. Berger, Iris D. Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynd, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Michael H. A. Roehrl, Prashant Bavi, Pamela S. Ohashi, Julia Y. Wang, Linh T.Nguyen, SeongJun Han, Heather L. MacGregor, Sara Hafezi-Bakhtiari, Bradly G. Wouters, Giuseppe V. Masucci, Emilia K. Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Cilberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Mihaela Angelova, Angela Vasaturo, Pauline Maby, Sarah E. Church, Helen K. Angell, Lucie Lafontaine, Daniela Bruni, Carine El Sissy, Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Jeffrey P. Meyers, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent- van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Kyogo Itoh, Prabhu S. Patel, Hemangini H. Vora, Birva Shah, ayendrakumar B. Patel, Kruti N. Rajvik, Shashank J. Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M. Marincola, Paolo A. Ascierto, Daniel J. Sargent, Bernard A. Fox, Jérôme Galon.
Matsushita M, Ozawa K, Suzuki T, Nakamura M, Nakano N, Kanchi S, Ichikawa D, Matsuki E, Sakurai M, Karigane D, Kasahara H, Tsukamoto N, Shimizu T, Mori T, Nakajima H, Okamoto S, Kawakami Y, Hattori Y.
<p>MicroRNAs (miRNAs/miRs) regulate the levels of transcripts and serve a critical function in the regulation of tumor microenvironments. Therefore, miRNA levels in cancer tissues are thought to be potential biomarkers for immunotherapy. From a ph...
Mori Mariko, Funakoshi Takeru, Kameyama Kaori, Kawakami Yutaka, Sato Eiichi, Nakayama Eiichi, Amagai Masayuki, Tanese Keiji
Journal of Dermatology 44(6) 671-680 Jun 2017
<p>The cancer-testis antigens (CTA) are a large family of tumor-associated antigens expressed by a variety of cancer cells and primitive germ cells of the adult testis and placenta. These tumor-restricted expressing patterns suggest that CTA would...
<p>Chronic graft-versus-host disease (cGVHD) is a notorious complication of allogeneic hematopoietic stem cell transplantation and causes disabling systemic inflammation and fibrosis. In this novel study, we focused on a relationship between endop...
Shindo Y, Hazama S, Suzuki N, Iguchi H, Uesugi K, Tanaka H, Aruga A, Hatori T, Ishizaki H, Umeda Y, Fujiwara T, Ikemoto T, Shimada M, Yoshimatsu K, Takenouchi H, Matsui H, Kanekiyo S, Iida M, Koki Y, Arima H, Furukawa H, Ueno T, Yoshino S, Fujita T, Kawakami Y, Nakamura Y, Oka M, Nagano H.
Journal of Experimental & Clinical Cnacer Research 36(1) 36 Feb 2017
Saito Katsuya, Ohta Shigeki, Kawakami Yutaka, Yoshida Kazunari, Toda Masahiro
Journal of Neuro-Oncology 132(1) 63-74 Jan 2017
<p>Kinesin family member 20A (KIF20A), an ideal cancer-testis antigen, was reported to be a promising immunotherapeutic target for pancreatic cancers. Clinical trials of KIF20A peptide vaccine immunotherapy have been conducted against pancreatic c...
<p>Macrophage migration inhibitory factor (MIF) plays an important role in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs); however, the downstream effectors of this factor remain unknown. Here, we show ...
<p>Cryoablative treatment has been widely used for treating cancer. However, the therapeutic efficacies are still controversial. The molecular mechanisms of the cryo-induced immune responses, particularly underlying the ineffectiveness, remain to ...
<p>Tumor-initiating cells thought to drive brain cancer are embedded in a complex heterogeneous histology. In this study, we isolated primary cells from 21 human brain tumor specimens to establish cell lines with high tumorigenic potential and to ...
<p>Fibrosis of organs is observed in systemic autoimmune disease. Using a scleroderma mouse, we show that transplantation of MHC compatible, minor antigen mismatched bone marrow stromal/stem cells (BMSCs) play a role in the pathogenesis of fibrosi...
<p>The homeobox protein, PEPP2 (RHOXF2), has been suggested as a cancer/testis (CT) antigen based on its expression pattern. However, the peptide epitope of PEPP2 that is recognized by cytotoxic T cells (CTLs) is unknown. In this study, we reveale...
Journal of Investigative Dermatology 136(1) 255-263 Jan 2016
<p>Recently, T-cell immunoreceptor with Ig and ITIM domains (TIGIT) was reported as a candidate for novel immune checkpoints. However, the impact of TIGIT on melanoma-specific cytotoxic T lymphocytes in the effector phase remains unclear. In this ...
<p>Although recent cancer immunotherapy strategies, including immune-checkpoint blockade (i.e. blocking PD-1, PD-L1 or CTLA-4), have shown durable clinical effects in some (but not all) patients with various advanced cancers, further understanding...
<p>The development of cancer immunotherapies is progressing rapidly with a variety of technological approaches. They consist of "cancer vaccines", which are based on the idea of vaccination, "effector cell therapy", classified as passive immunothe...
Response of nivolumab monotherapy in 124 Japanese patients with advanced melanoma; Interim analysis of prospective observational study (CREATIVE study)
N Yamazaki, A Takahashi, K Namikawa, T Takenouchi, Y Nakamura, S Kitano, T Fujita, K Kubota, T Yamanaka, Y Kawakami.
ESMO Asia Congress 2019 24 Nov 2019
Immunoscore predicts significant differences in time to recurrence in stage I colon cancer patients
Jérôme Galon, Fabienne Hermitte, Bernhard Mlecnik, Florence Marliot, Carlo Bifulco, Alessandro Lugli, Iris D Nagtegaal, Arndt Hartmann, Marc Van den Eynde, Michael H A Roehrl, Pamela S Ohashi, Eva Zavadova, Toshihiko Torigoe, Prabhu S Patel, Yili Wang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Bernard A Fox, Franck Pagès.
ESMO Asia Congress 2019 24 Nov 2019
Significant differences in outcome between Immunoscore categories in stage I colon cancer patients
Jérôme Galon, Fabienne Hermitte, Bernhard Mlecnik, Florence Marliot, Carlo Bifulco, Alessandro Lugli, Iris D Nagtegaal, Arndt Hartmann, Marc Van den Eynde, Michael H A Roehrl, Pamela S Ohashi, Eva Zavadova, Toshihiko Torigoe, Prabhu S Patel, Yili Wang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Bernard A Fox, Franck Pagès.
The ESMO 21st World Congress on Gastrointestinal Cancer 5 Jul 2019
Multicenter phase I/II study of nivolumab combined with paclitaxel plus ramucirumab as the second-line treatment in patients with advanced gastric cancer,
12P-MSI status plus immunoscore to select metastatic colorectal cancer patients for immunotherapies
J. Galon, B. Mlecnik, F. Hermitte, F. Marliot, C. Bifulco, A. Lugli, I.D. Nagtegaal, A. Hartmann, M. van den Eynde, M. Roehrl, P. Ohashi, E. Zavadova, T. Torigoe, P.Patel, Y. Wang, Y. Kawakami, F.M. Marincola, P.A. Ascierto, B. Fox, F. Pagès
ESMO Immuno Oncology Congress 2018 14 Dec 2018
免疫チェックポイント阻害薬がもたらした新たながん免疫研究の展開,
KAWAKAMI YUTAKA
13 Dec 2018
Inhibition of vascular adhesion protein-1 enhances antitumor-effects of immune checkpoint inhibitors by reducing inflammatory tumor microenvironment
Mohammad Abu Sayem, Tomonari Kinoshita, Tomonori Yaguchi, Budiman Kharma, Kenji Morii, Yukihiko Mashima, Yutaka Kawakami.
12 Dec 2018
A new humanized mouse model to investigate large granular lymphocytosis in CML patients and immunemodulating effects of dasatinib
Tumor-infiltarating lymphocytes from patients with cervical cancers are tumor-reactive and human papillomavirus E6/E7-specific: Potential use for adoptive cell therapy
Mohammad A. Sayem, Nuchsupa Sunthamala, Tomonori Yaguchi, Takashi Iwata, Tomonobu Fujita, Yutaka Kawakami.
The 45thNaito Conference 27 Jun 2018
がんにおけるCD8+ T細胞の意義：Immunoscore and beyond[Invited]
河上裕
第107回日本病理学会総会 21 Jun 2018
腫瘍免疫学と癌免疫療法の最近の展開[Invited]
河上裕
第14回北関東小児がんセミナー 19 May 2018
Keynote Speech: Recent Progress and Future Perspectives of Cancer Immunotherapy Combination.[Invited]
Yutaka Kawakami
7thJapan Taiwan Oncology Phase I Trial Conference 21 Apr 2018
Recent advances and future perspecttives in immunotherapy for melanoma.[Invited]
Kawakami Yutaka
19thHamchun Dermatology Symposium 9 Dec 2017
Key Note Lecture「Understanding of tumor immune-microenvironment through genetic and immunological analyses for development of effective cancer immunothrapy.[Invited]
Kawakami Yutaka
Sarcoma Research 1 Dec 2017
Immunobiology and immunotherapy for gynecological cancers[Invited]
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