MISC

1997年6月

NF-kappa B inhibitors stimulate apoptosis of rabbit mature osteoclasts and inhibit bone resorption by these cells

FEBS LETTERS
  • K Ozaki
  • ,
  • H Takeda
  • ,
  • H Iwahashi
  • ,
  • S Kitano
  • ,
  • S Hanazawa

410
2-3
開始ページ
297
終了ページ
300
記述言語
英語
掲載種別
DOI
10.1016/S0014-5793(97)00653-4
出版者・発行元
ELSEVIER SCIENCE BV

Interesting, recent studies have suggested a possibility that transcriptional factor NF-kappa B may play a functional role in the survival of mouse osteoclasts. However, it has not been known. whether NF-kappa B is involved in apoptosis of and bone resorption by mature osteoclasts. Thus, using NF-kappa B inhibitors, we examined the functional role of NF-kappa B in the induction of apoptosis in rabbit mature osteoclasts. PDTC, a potent inhibitor of NF-kappa B, stimulated markedly apoptosis of the osteoclasts and inhibited bone resorption by these cells. These effects also was observed when three other inhibitors of NF-kappa B were used. And a gel mobility shift assay showed that PDTC also inhibited NF-kappa B binding to its consensus sequence in the cells. These results suggest a regulatory role for NF-kappa B in apoptosis in and bone resorption by rabbit mature osteoclasts. (C) 1997 Federation of European Biochemical Societies.

Web of Science ® 被引用回数 : 67

リンク情報
DOI
https://doi.org/10.1016/S0014-5793(97)00653-4
CiNii Articles
http://ci.nii.ac.jp/naid/80009775066
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9237649
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1997XL00100038&DestApp=WOS_CPL

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