MISC

2000年2月

Role of transcriptional factor activation protein-1 in endogenous expression of the interleukin-1 beta gene involved in Porphyromonas gingivalis fimbria-stimulated bone resorption in the mouse calvarial system

ORAL MICROBIOLOGY AND IMMUNOLOGY
  • K Naganuma
  • ,
  • S Amano
  • ,
  • H Takeda
  • ,
  • S Kitano
  • ,
  • S Hanazawa

15
1
開始ページ
53
終了ページ
57
記述言語
英語
掲載種別
DOI
10.1034/j.1399-302X.2000.150109.x
出版者・発行元
MUNKSGAARD INT PUBL LTD

We previously suggested that endogenous interleukin-1 beta (IL-1 beta) produced by Porphyromonas gingivalis fimbriae stimulation in calvarial bone cell cultures plays a role in bone resorption as a major cytokine. Therefore, in the present study, we initiated experiments to clarify the stimulatory mechanism of IL-1 beta gene expression in fimbria-stimulated bone resorption. Fimbria-stimulated bone resorption was dramatically inhibited by curcumin, a potent inhibitor of activation protein-1 (AP-1). In fact, the fimbriae induced markedly both the expression of c-fos and c-jun genes and their protein production in the calvarial cells. In addition, a mixture of antisense oligonucleotides against c-fos and c-jun significantly inhibited not only the fimbria-induced expression of the IL-1 beta gene but also the fimbria-induced bone resorption. Therefore, the present study demonstrates that transcriptional factor AP-1 plays a functional role in P. gingivalis fimbria-stimulated, bone resorption via endogenous IL-1 beta in the mouse calvarial system.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1034/j.1399-302X.2000.150109.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000084918900009&DestApp=WOS_CPL

エクスポート
BibTeX RIS