OHBA Tomoyuki

J-GLOBAL         Last updated: Jun 19, 2019 at 13:40
OHBA Tomoyuki
Saitama University

Research Areas


Academic & Professional Experience

Hosei University 
Former Institution / Organization Kyushu University Faculty of Medical Sciences 


Apr 1994
Mar 1997
Graduate School, Division of Medicine, Kyushu University

Published Papers

Daidoji T, Watanabe Y, Ibrahim MS, Yasugi M, Maruyama H, Masuda T, Arai F, Ohba T, Honda A, Ikuta K, Nakaya T
The Journal of biological chemistry   290(17) 10627-10642   Apr 2015   [Refereed]
Hanihara F, Takahashi Y, Okuma A, Ohba T, Muta T
International immunology   25(9) 531-544   Sep 2013   [Refereed]
Okuma A, Hoshino K, Ohba T, Fukushi S, Aiba S, Akira S, Ono M, Kaisho T, Muta T
Immunity   38(3) 450-460   Mar 2013   [Refereed]
Ohba T, Ariga Y, Maruyama T, Truong NK, Inoue J, Muta T
The FEBS journal   279(2) 211-222   Jan 2012   [Refereed]
Ohba T, Nishijima H, Nishitani H, Nishimoto T
Genes to cells : devoted to molecular & cellular mechanisms   13(6) 571-582   Jun 2008   [Refereed]
Ohba T, Schirmer EC, Nishimoto T, Gerace L
The Journal of cell biology   167(6) 1051-1062   Dec 2004   [Refereed]
The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome.
Suzuki N, Noguchi E, Nakashima N, Oki M, Ohba T, Tartakoff A, Ohishi M, Nishimoto T
Genetics   158(2) 613-625   Jun 2001   [Refereed]
T. Ohba, M. Nakamura, H. Nishitani, T. Nishimoto
Science   284(5418) 1356-1358   May 1999
The nucleotide exchange activity of RCC1, the only known nucleotide exchange factor for Ran, a Ras-like small guanosine triphosphatase, was required for microtubule aster formation with or without demembranated sperm in Xenopus egg extracts arrest...
Nakamura M, Masuda H, Horii J, Kuma Ki, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T
The Journal of cell biology   143(4) 1041-1052   Nov 1998   [Refereed]
Azuma Y, Seino H, Seki T, Uzawa S, Klebe C, Ohba T, Wittinghofer A, Hayashi N, Nishimoto T
Journal of biochemistry   120(1) 82-91   Jul 1996   [Refereed]
Tomoyuki Ohba, Takashi Seki, Yoshiaki Azuma, Takeharu Nishimoto
The Journal of Biological Chemistry   271(25) 14665-14667   Jan 1996
RCC1 is a guanine nucleotide exchanging factor acting on nuclear G protein Ran. Premature chromatin condensation occurs in the temperature-sensitive reel mutant of the BHK21 cell line, tsBN2, at the restrictive temperature. This observation can be...
N. Yokoyama, N. Hayashi, T. Seki, N. Panté, T. Ohba, K. Nishii, K. Kuma, T. Hayashida, T. Miyata, U. Aebi, M. Fukui, T. Nishimoto
Nature   376 184-188   Jul 1995
RAN/TC4 is a small nuclear G protein1 that forms a complex with the chromatin-bound guanine nucleotide release factor RCC1 (ref. 2). Loss of RCC1 causes defects in cell cycle progression3, 4, RNA export5−7 and nuclear protein import8. Some of thes...
RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.
Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T
Molecular & general genetics : MGG   247(6) 661-669   Jun 1995   [Refereed]
A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.
Dasso M, Seki T, Azuma Y, Ohba T, Nishimoto T
The EMBO journal   13(23) 5732-5744   Dec 1994   [Refereed]
The CCG1/TAFII250 gene is mutated in thermosensitive G1 mutants of the BHK21 cell line derived from golden hamster.
Hayashida T, Sekiguchi T, Noguchi E, Sunamoto H, Ohba T, Nishimoto T
Gene   141(2) 267-270   Apr 1994   [Refereed]

Research Grants & Projects

A small G protein Ran,Regulator of Aster formation