2020年11月
A dynamically deformable microfilter for selective separation of specific substances in microfluidics.
Biomicrofluidics
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 14
- 号
- 6
- 開始ページ
- 064113
- 終了ページ
- 064113
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1063/5.0025927
To study an environmental or biological solution, it is essential to separate its constituents. In this study, a 3D-deformable dynamic microfilter was developed to selectively separate the target substance from a solution. This microfilter is a fine metallic nickel structure fabricated using photolithography and electroplating techniques. It is gold-coated across its entire surface with multiple slits of 10-20 μm in width. Its two-dimensional shape is deformed into a three-dimensional shape when used for fluid separation due to hydrodynamic forces. By adjusting the pressure applied to the microfilter, the size of the gap created by deformation can be changed. To effectively isolate the target substance, the relationship between the solution flow rate and the extent of microfilter deformation was investigated. The filtration experiments demonstrated the microfilter's ability to isolate the target substance with elastic deformation without undergoing plastic deformation. Additionally, modification of the microfilter surface with nucleic acid aptamers resulted in the selective isolation of the target cell, which further demonstrates the potential application of microfilters in the isolation of specific components of heterogeneous solutions.
- リンク情報
-
- DOI
- https://doi.org/10.1063/5.0025927
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/33425088
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772001
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85099515451&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85099515451&origin=inward
- ID情報
-
- DOI : 10.1063/5.0025927
- ISSN : 1932-1058
- ORCIDのPut Code : 85907784
- PubMed ID : 33425088
- PubMed Central 記事ID : PMC7772001
- SCOPUS ID : 85099515451