論文

査読有り 国際誌
2020年11月

A dynamically deformable microfilter for selective separation of specific substances in microfluidics.

Biomicrofluidics
  • Seitaro Kumamoto
  • ,
  • Kenshiro Nakatake
  • ,
  • Souichiro Fukuyama
  • ,
  • Keiichiro Yasuda
  • ,
  • Yusuke Kitamura
  • ,
  • Masaaki Iwatsuki
  • ,
  • Hideo Baba
  • ,
  • Toshihiro Ihara
  • ,
  • Yoshitaka Nakanishi
  • ,
  • Yuta Nakashima

14
6
開始ページ
064113
終了ページ
064113
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1063/5.0025927

To study an environmental or biological solution, it is essential to separate its constituents. In this study, a 3D-deformable dynamic microfilter was developed to selectively separate the target substance from a solution. This microfilter is a fine metallic nickel structure fabricated using photolithography and electroplating techniques. It is gold-coated across its entire surface with multiple slits of 10-20 μm in width. Its two-dimensional shape is deformed into a three-dimensional shape when used for fluid separation due to hydrodynamic forces. By adjusting the pressure applied to the microfilter, the size of the gap created by deformation can be changed. To effectively isolate the target substance, the relationship between the solution flow rate and the extent of microfilter deformation was investigated. The filtration experiments demonstrated the microfilter's ability to isolate the target substance with elastic deformation without undergoing plastic deformation. Additionally, modification of the microfilter surface with nucleic acid aptamers resulted in the selective isolation of the target cell, which further demonstrates the potential application of microfilters in the isolation of specific components of heterogeneous solutions.

リンク情報
DOI
https://doi.org/10.1063/5.0025927
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33425088
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772001
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85099515451&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85099515451&origin=inward
ID情報
  • DOI : 10.1063/5.0025927
  • ISSN : 1932-1058
  • ORCIDのPut Code : 85907784
  • PubMed ID : 33425088
  • PubMed Central 記事ID : PMC7772001
  • SCOPUS ID : 85099515451

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