2010年4月
PEG-PLA nanoparticles prepared by emulsion solvent diffusion using oil-soluble and water-soluble PEG-PLA
MATERIALS LETTERS
- ,
- ,
- 巻
- 64
- 号
- 8
- 開始ページ
- 969
- 終了ページ
- 971
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.matlet.2010.01.076
- 出版者・発行元
- ELSEVIER SCIENCE BV
Poly(ethylene glycol)-block-polylactide (PEG-PLA) nanoparticles were prepared through the oil-in-water (O/W, ethyl acetate/water) emulsion technique using oil-soluble PEG-PLA in the presence of water-soluble PEG-PLA as a surfactant. The particle diameter decreased with increasing water-soluble PEG-PLA concentration, the smallest averaged diameter was 75 nm. From these results, it was found that water-soluble PEG-PLA acted as a surfactant which prevents further coalescence of droplets. In addition, the particles diameter decreased with increasing hydrophile-lipophile balance of oil-soluble PEG-PLA in the absence of water-soluble PEG-PLA. In contrast, the particle diameter was constant in the presence of water-soluble PEG-PLA. Therefore, the capability of water-soluble PEG-PLA as a surfactant was more excellent than that of oil-soluble PEG-PLA. (C) 2010 Elsevier B.V. All rights reserved
- リンク情報
- ID情報
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- DOI : 10.1016/j.matlet.2010.01.076
- ISSN : 0167-577X
- eISSN : 1873-4979
- Web of Science ID : WOS:000276138400024