OKAMOTO Kuniaki

J-GLOBAL         Last updated: Nov 28, 2018 at 14:40
 
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Name
OKAMOTO Kuniaki
Affiliation
Okayama University
Section
Graduate School of Medicine ,Dentistry and Pharmaceutical Sciences
Job title
Associate Professor
Degree
(BLANK)(Kyushu University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2007
 - 
Apr 2017
Associate professor, Dental Pharmacology, Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University
 
Apr 2003
 - 
Mar 2007
Associate professor, Dental Pharmacology, Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University
 
2003
 - 
2004
 Associate Professor
 
2004
   
 
 Associate Professor
 
Apr 2001
 - 
Mar 2003
Associate professor, Dental Pharmacology, Faculty of Dentistry, Nagasaki University
 

Education

 
 
 - 
1996
Graduate School, Division of Dental Research, Kyushu University
 
 
 - 
1990
Faculty of Dentistry, Kyushu University
 

Published Papers

 
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells.
Namba Y, Sogawa C, Okusha Y, Kawai H, Itagaki M, Ono K, Murakami J, Aoyama E, Ohyama K, Asaumi JI, Takigawa M, Okamoto K, Calderwood SK, Kozaki KI, Eguchi T
Front Oncol.      Oct 2018   [Refereed]
Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment.
Eguchi T, Sogawa C, Okusha Y, Uchibe K, Iinuma R, Ono K, Nakano K, Murakami J, Itoh M, Arai K, Fujiwara T, Namba Y, Murata Y, Ohyama K, Shimomura M, Okamura H, Takigawa M, Nakatsura T, Kozaki KI, Okamoto K, Calderwood SK
PLoS One.   13(2)    Feb 2018   [Refereed]
Transcription factor EB (TFEB) influences invasion and migration in oral squamous cell carcinomas.
Sakamoto H, Yamashita K, Okamoto K, Kadowaki T, Umeda M, Tsukuba T
Oral Dis.      2018   [Refereed]
Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion.
Narahara H, Sakai E, Yamaguchi Y, Narahara S, Iwatake M, Okamoto K, Yoshida N, Tsukuba T
J Cell physiol.      2018   [Refereed]
Rutaecarpine attenuates osteoclastogenesis by impairing M-CSF and RANKL-stimulated signaling pathways.
Fukuma Y, Sakai E, Komaki S, Nishishita K, Okamoto K, Tsukuba T
Clin Exp Pharmacol Physiol.      2018   [Refereed]

Misc

 
Shibata M., Sakai H., Sakai E., Okamoto K., Yasuda Y., Kato Y., Yamamoto K.
European Journal of Pharmacology   270(6) 1189-1198   2003
Okaji M., Sakai H., Sakai E., Shibata M., Hashimoto F., Kobayashi Y., Yoshida N., Okamoto K., Yamamoto K., Kato Y.
The Journal of Pharmacological Sciences   91(4) 285-294   2003
Tsukuba T., Okamoto K., Okamoto Y., Yanagawa M., Kohmura K., Yasuda Y., Uchi H., Nakahara T., Furue M., Nakayama K., Kadowaki T., Yamamoto K., Nakayama K-I.
Journal of Biochemistry   134(6) 893-902   2003
Yuasa K., Fukumoto S., Kamasaki Y., Yamada A., Fukumoto E., Kanaoka K., Saito K., Harada H., Arikawa-Hirasawa E., Miyagoe-Suzuki Y., Takeda S., Okamoto K., Kato Y., Fujiwara T.
Journal of Biological Chemistry   279(11) 10286-10292   2004
Abe N., Baba A., Takii R., Nakayama K., Kamaguchi A., Shibata Y., Abiko Y., Okamoto K., Kadowaki T., Yamamoto K.
Biological Chemistry   385(11) 1041-1047   2004

Books etc

 
Arg-gingipain and Lys-gingipain: a novel class of cysteine proteinases.
Yamamoto K, Kadowaki T, Okamoto K (Part:Joint Work)
Birkhäusen Verlag   1999   
Possible roles of N-linked oligosaccharides on cathepsin E
IOS Press   1997   
Structural characterization of pathogenic cysteine proteinase from the oral bacterium Porphysromonas gingivalis
IOS Press   1997   
Biosynthesis and trafficking of cathepsin E
IOS Press   1997   

Conference Activities & Talks

 
Cathepsin E mediates membrane trafficking in macrophages
2007   
ASSOCIATION OF CATHEPSIN E WITH HOST DEFFENCE AGAINST TUMOR CELLS
2007   
CONTROL OF THE ENDOSOME/LYSOSOME SYSTEM OF MACROPHAGES BY CATHEPSIN E
2007   
IMPAIRMENT OF AUTOPHAGY ACCOMPANIED BY INCREASED ABERRANT MITOCHONDRIA AND OXIDATIVE STRESS IN CATHEPSIN E DEFICIENT MACROPHAGES
2009   
Transcription factor Sp1 regulates the expression of the murine cathepsin E gene in gastric adenosarcoma cells
2010   

Research Grants & Projects

 
Study on transport of aspartic proteinase
Project Year: 1993   
Study on proteinase from periodontal pathogen
Project Year: 1993   
The role of proteinase in osteoclast formation and activation
Grant-in-Aid for Scientific Research
Project Year: 2001