1999年11月
Effect of gemfibrozil on triacylglycerol synthesis and secretion by liver and lipoprotein lipase activity in adipose tissue of rats
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
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- 巻
- 124
- 号
- 3
- 開始ページ
- 289
- 終了ページ
- 294
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0305-0491(99)00121-2
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
The role of gemfibrozil, a hypotriglyceridemic drug, in synthesis, secretion and catabolism of triacylglycerols (TG) in rats was assessed. Chow diet-fed Sprague-Dawley rats were given Various doses of gemfibrozil (10, 30 and 100 mg/kg body weight) for 2 weeks. Rats receiving the drug at the lowest dose significantly lowered the concentration of serum TG and apolipoprotein (apo) B in comparison with control rats. Synthesis of fatty acids from [C-14]acetate and esterification of [C-14]oleate to TG by the liver were not suppressed by the drug. Secretion rates of TG and apo B: measured by the Triton method, were suppressed at the highest dose. Lipoprotein lipase activity of the acetone powder prepared from adipose tissue was not influenced by the drug. These results indicate that the primary cause of hypotriglyceridemic action of gemfibrozil is not due to suppressing synthesis and secretion of TG by the liver or enhancing lipoprotein lipase activity in adipose tissues. (C) 1999 Elsevier Science Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/S0305-0491(99)00121-2
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10631806
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083624900008&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0032742066&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0032742066&origin=inward
- ID情報
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- DOI : 10.1016/S0305-0491(99)00121-2
- ISSN : 0305-0491
- PubMed ID : 10631806
- SCOPUS ID : 0032742066
- Web of Science ID : WOS:000083624900008