MISC

2003年10月

Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • K Nagao
  • ,
  • N Inoue
  • ,
  • YM Wang
  • ,
  • T Yanagita

310
2
開始ページ
562
終了ページ
566
記述言語
英語
掲載種別
DOI
10.1016/j.bbrc.2003.09.044
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Adiponectin is a recently discovered hormone secreted by adipocytes that has been reported to enhance insulin sensitivity. Although insulin resistance and/or compensatory hyperinsulinemia are considered to be involved with hypertension in obese humans, the relationship between plasma adiponectin level and obesity-related hypertension has not been fully clarified. In this study, we investigated the effect of dietary conjugated linoleic acid (CLA), reported as an insulin sensitizer, on plasma adiponectin, plasma insulin, and blood pressure in Zucker diabetic fatty (ZDF) rats. During the onset of obesity, blood pressure increased in ME rats. The increase, however, was prevented by dietary CLA. After 8 weeks, accumulated plasma insulin and glucose were also attenuated by CLA feeding. Dietary CLA increased plasma adiponectin levels in ME rats and the increase was attributed to the enhanced mRNA expression in white adipose tissue. This study provides the first evidence that dietary CLA increases plasma adiponectin level through the enhancement of mRNA expression. We speculate that the increase alleviates hyperinsulinemia and prevents the onset of hypertension in CLA-fed ZDF rats. (C) 2003 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 116

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2003.09.044
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000185904300046&DestApp=WOS_CPL

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