MISC

2009年4月

Learning Signals from the Superior Colliculus for Adaptation of Saccadic Eye Movements in the Monkey

JOURNAL OF NEUROSCIENCE
  • Yuki Kaku
  • ,
  • Kaoru Yoshida
  • ,
  • Yoshiki Iwamoto

29
16
開始ページ
5266
終了ページ
5275
記述言語
英語
掲載種別
DOI
10.1523/JNEUROSCI.0661-09.2009
出版者・発行元
SOC NEUROSCIENCE

Vital to motor learning is information about movement error. Using this information, the brain creates neural learning signals that instruct a plasticity mechanism to produce appropriate behavioral learning. Little is known, however, about brain structures that generate learning signals for voluntary movements. Here we show that signals from the superior colliculus (SC) can drive learning in saccadic eye movements in the monkey. Electrical stimulation of the SC deeper layers, subthreshold for evoking saccades, was applied immediately (similar to 60 ms) after the end of horizontal saccades in one or both directions. The target disappeared during saccades and remained invisible for 1 s to eliminate effects of postsaccadic visual information. Repetitive pairing of saccades with SC stimulation produced a marked, two-dimensional shift in movement endpoint relative to the target location. The elicited endpoint shift took a gradual, approximately exponential course over several hundred saccades as in visually induced saccade adaptation. The shift in movement endpoint remained nearly unchanged after stimulation was discontinued, indicating involvement of neuronal plasticity. When both rightward and leftward saccades were paired with stimulation, their endpoints shifted in similar directions. The endpoint shift was directed contralaterally to the stimulated SC. The direction and size of the endpoint shift depended on the stimulation site in the SC. We propose that the SC, a brainstem structure long known to be crucial for saccade execution, is involved in motor learning and sends signals that dictate the direction of adaptive shift in saccade endpoint.

Web of Science ® 被引用回数 : 31

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.0661-09.2009
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000265450300025&DestApp=WOS_CPL

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