MISC

2007年2月

Glycinergic inputs cause the pause of pontine omnipause neurons during saccades

NEUROSCIENCE LETTERS
  • Takeshi Kanda
  • ,
  • Yoshiki Iwamoto
  • ,
  • Kaoru Yoshida
  • ,
  • Hiroshi Shimazu

413
1
開始ページ
16
終了ページ
20
記述言語
英語
掲載種別
DOI
10.1016/j.neulet.2006.11.024
出版者・発行元
ELSEVIER IRELAND LTD

Pontine omnipause neurons (OPNs) are inhibitory neurons projectingto saccade-relatedpremotor burst neurons. OPNs exhibit sustained discharge during fixations and cease firing before and during saccades. The pause in OPN discharge releases the burst neurons from tonic inhibition, resulting in generation of saccadic eye movements. OPNs are thought to receive two major inhibitory inputs during saccades: an early component that determines the pause onset and a late component that controls the pause duration. Although there is evidence that numerous glycinergic and GABAergic terminals contact OPNs, their physiological roles remain unclear. To reveal functions of glycinergic and GABAergic inputs, we investigated effects of iontophoretic application of strychnine, a glycine receptor antagonist, and bicuculline, a GABA(A) receptor antagonist, on discharge patterns of OPNs in alert cats. Application of strychnine reduced the ratio of pause duration to saccade duration. Analysis of the timing of pause relative to saccades showed that pause onset was delayed and pause end was advanced. These effects were observed for saccades in all directions. Application of bicuculline, in contrast, had no effect on the OPN pause duration or timing. Both strychnine and bicuculline increased tonic firing rate during intersaccadic intervals. These results suggest that glycinergic, but not GABAergic, afferents convey inhibitory signals that determine the onset as well as duration of pause in OPN activity during saccades. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2006.11.024
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000244574800004&DestApp=WOS_CPL

エクスポート
BibTeX RIS