MISC

2007年4月

Microstimulation of the midbrain tegmentum creates learning signals for saccade adaptation

JOURNAL OF NEUROSCIENCE
  • Yoshiko Kojima
  • ,
  • Kaoru Yoshida
  • ,
  • Yoshiki Iwamoto

27
14
開始ページ
3759
終了ページ
3767
記述言語
英語
掲載種別
DOI
10.1523/JNEUROSCI.4958-06.2007
出版者・発行元
SOC NEUROSCIENCE

Error signals are vital to motor learning. However, we know little about pathways that transmit error signals for learning in voluntary movements. Here we show that microstimulation of the midbrain tegmentum can induce learning in saccadic eye movements in monkeys. Weak electrical stimuli delivered similar to 200 ms after saccades in one horizontal direction produced gradual and marked changes in saccade gain. The spatial and temporal characteristics of the produced changes were similar to those of adaptation induced by real visual error. When stimulation was applied after saccades in two different directions, endpoints of these saccades gradually shifted in the same direction in two dimensions. We conclude that microstimulation created powerful learning signals that dictate the direction of adaptive shift in movement endpoints. Our findings suggest that the error signals for saccade adaptation are conveyed in a pathway that courses through the midbrain tegmentum.

Web of Science ® 被引用回数 : 17

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.4958-06.2007
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000245468300017&DestApp=WOS_CPL

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