Kumagai Yoshito

J-GLOBAL         Last updated: Jun 6, 2019 at 02:50
 
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Name
Kumagai Yoshito
URL
http://www.md.tsukuba.ac.jp/environmental_medicine/index.html
Affiliation
University of Tsukuba
Section
Faculty of Medicine
Job title
Professor

Research Areas

 
 

Education

 
 
 - 
1982
Faculty of Pharmaceutical Science, Fukuoka University
 
 
 - 
1988
Graduate School, Division of Pharmaceutical Sciences, Fukuoka University
 

Committee Memberships

 
Jan 2017
   
 
Oxford Journal  Toxicological Sciences Associate Editor
 
Jul 2015
 - 
Jun 2018
Asian Society of Toxicology  Councilor & Auditor
 
Jul 2012
 - 
Jul 2015
Treasurer
 
Jul 2011
 - 
Dec 2011
Journal of Health Science編集委員会編集委員長
 
Jan 2011
 - 
Dec 2016
Oxford Journal  Toxicological Sciences Editorial Board Member
 

Published Papers

 
Fujie, Tomoya; Takenaka, Fukuta; Yoshida, Eiko; Yasuike, Shuji; Fujiwara, Yasuyuki; Shinkai, Yasuhiro; Kumagai, Yoshito; Yamamoto, Chika; Kaji, Toshiyuki
The Journal of toxicological sciences   44(5) 327-333   Apr 2019   [Refereed]
Metallothionein (MT) is a low-molecular-weight, cysteine-rich, and metal-binding protein that protects cells from the cytotoxic effects of heavy metals and reactive oxygen species. Previously, we found that transcriptional induction of endothelial...
Shinkai, Yasuhiro;Kumagai, Yoshito
TOXICOLOGICAL SCIENCES   kfz091   2019   [Refereed]
Electrophiles can undergo covalent modification of cellular proteins associated with its dysfunction, thereby exerting toxicity. Small nucleophilic molecules such as glutathione protect cells from electrophilic insult by binding covalently to elec...
ABIKO,Yumi;ISAO,Ishii;KAMATA,Shotaro;TSUCHIYA,Yukihiro;WATANABE,Yasuo;IHARA,Hideshi;AKAIKE,Takaaki;KUMAGAI,Yoshito
Annual Meeting of the Japanese Society of Toxicology   43 P-238   2016   [Refereed]
[目的] アセトアミノフェン(APAP)は、その毒性の原因であるN-アセチル-p-ベンゾキノンイミン(NAPQI)に生体内で代謝活性化される。親電子物質であるNAPQIは、グルタチオン(GSH)のシステイン残基(Cys)と結合し、解毒・排泄される。一方、我々は、シスタチオニンγ-リアーゼ (CSE) がCysおよびGSHのパースルフィド/ポリスルフィド体(CysS-SH/CysS-SnHおよびGS-SH/GS-S-SG)のような活性イオウ分...
AKIYAMA,Masahiro;TOYAMA,Takashi;YOSHIDA,Eiko;UNOKI,Takamitsu;ABIKO,Yumi;SHINKAI,Yasuhiro;KUMAGAI,Yoshito
Annual Meeting of the Japanese Society of Toxicology   43 P-8   2016   [Refereed]
【目的】メチル水銀(MeHg)はタンパク質のシステイン残基と容易に共有結合し, 付加体を形成する(S-水銀化). MeHg曝露量の増加によりタンパク質のS-水銀化が過剰に行われると, レドックスホメオスタシスの撹乱に伴う被修飾タンパク質の担う細胞機能が破綻し, これがMeHgによる毒性発現の主因と考えられている. 近年, 我々は東北大・赤池教授らとの共同研究により, 生体内において非常に高い求核性/抗酸化性を呈する活性イオウ分子 (Reactive sulfur...
LUONG,Nho Cong;ABIKO,Yumi;KUMAGAI,Yoshito
Annual Meeting of the Japanese Society of Toxicology   44 P-277   2017   [Refereed]
Redox regulation through cysteine modification of proteins involves in maintaining intracellular homeostasis. Protein tyrosine phosphatases (PTPs) negatively regulate EGFR, which regulates cell survival. Once PTPs undergo oxidation through cystein...

Books etc

 
Arsenic Contamination in Asia
Kumagai, Yoshito;Yumi, Abiko (Part:Contributor, Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic)
Springer, Singapore   Dec 2018   ISBN:9789811325649
RSSによる環境中親電子物質の解毒代謝
熊谷嘉人 (Part:Contributor, RSSによる環境中親電子物質の解毒代謝)
Apr 2015   
地球規模におけるヒ素汚染の現状
安孫子, ユミ;熊谷, 嘉人 (Part:Contributor, 地球規模におけるヒ素汚染の現状)
Jul 2010   
実験医学増刊号
熊谷,嘉人 (Part:Contributor, 親電子シグナル伝達)
Sep 2009   
National Institute on Drug Abuse Monograph
Cho,AK;Hiramatsu,M;Kumagai,Y;Patel,N (Part:Contributor, Pharmacokinetic approach to the study of durg action and toxicology)
Jan 1992   

Conference Activities & Talks

 
Activation of redox signal transduction pathways mediated by electrophilic metals [Invited]
Kumagai,Yoshito
10th Congress of Toxicology in Developing Countries   Apr 2018   
環境中親電子物質エクスポソームと防御応答・適応 [Invited]
熊谷,嘉人
生理学研究所 研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」   Apr 2018   
エクスポソームと生命環境応答・適応 [Invited]
熊谷,嘉人
第71回日本酸化ストレス学会・第18回日本NO学会合同学術集会   May 2018   
Environmental electrophiles and reactive sulfur species: implications to regulation of redox signaling and toxicity [Invited]
Kumagai,Yoshito
The 8th International Congress of Asian Society of Toxicology   Jun 2018   
Electrophilic stress: Good or bad? [Invited]
Kumagai,Yoshito
The 6th Conference of the Japanese Association for Hypoxia Biology International Symposium for Innovative Areas "Oxygen Biology" and New Insights into Ion Channel Functions and Pharmacology​​   Jul 2018