Kumagai Yoshito

J-GLOBAL         Last updated: Oct 3, 2019 at 02:51
Kumagai Yoshito
University of Tsukuba
Faculty of Medicine
Job title

Research Areas



Faculty of Pharmaceutical Science, Fukuoka University
Graduate School, Division of Pharmaceutical Sciences, Fukuoka University

Committee Memberships

Jan 2017
Oxford Journal  Toxicological Sciences Associate Editor
Jul 2015
Jun 2018
Asian Society of Toxicology  Councilor & Auditor
Jul 2012
Jul 2015
Jul 2011
Dec 2011
Journal of Health Science編集委員会編集委員長
Jan 2011
Dec 2016
Oxford Journal  Toxicological Sciences Editorial Board Member

Published Papers

Nishimura, Akiyuki; Shimoda, Kakeru; Tanaka, Tomohiro; Toyama, Takashi; Nishiyama, Kazuhiro; Shinkai, Yasuhiro; Numaga-Tomita, Takuro; Yamazaki, Daiju; Kanda, Yasunari; Akaike, Takaaki; Kumagai, Yoshito; Nishida, Motohiro
Science signaling   12(587)    Jun 2019   [Refereed]
Chronic exposure to methylmercury (MeHg), an environmental electrophilic pollutant, reportedly increases the risk of human cardiac events. We report that exposure to a low, non-neurotoxic dose of MeHg precipitated heart failure induced by pressure...
Akiyama, Masahiro; Unoki, Takamitsu; Shinkai, Yasuhiro; Ishii, Isao; Ida, Tomoaki; Akaike, Takaaki; Yamamoto, Masayuki; Kumagai, Yoshito
Environmental health perspectives   127(6)    Jun 2019   [Refereed]
[BACKGROUND] Transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) plays a key role in detoxification of electrophiles via formation of glutathione (GSH) adducts and subsequent excretion into extracellular spaces. We found that r...
Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both.
Masahiro, Akiyama;T, Unoki;Yasuhiro, Shinkai;I, Ishii;T, Ida;T, Akaike;M, Yamamoto;Kumagai, Yoshito
Environmental Health Perspectives      Jun 2019   [Refereed]
Fujie, Tomoya; Takenaka, Fukuta; Yoshida, Eiko; Yasuike, Shuji; Fujiwara, Yasuyuki; Shinkai, Yasuhiro; Kumagai, Yoshito; Yamamoto, Chika; Kaji, Toshiyuki
The Journal of Toxicological Sciences   44(5) 327-333   Apr 2019   [Refereed]
<p>Metallothionein (MT) is a low-molecular-weight, cysteine-rich, and metal-binding protein that protects cells from the cytotoxic effects of heavy metals and reactive oxygen species. Previously, we found that transcriptional induction of endothel...
Shinkai, Yasuhiro;Kumagai, Yoshito
TOXICOLOGICAL SCIENCES   kfz091   2019   [Refereed]
Electrophiles can undergo covalent modification of cellular proteins associated with its dysfunction, thereby exerting toxicity. Small nucleophilic molecules such as glutathione protect cells from electrophilic insult by binding covalently to elec...

Books etc

Arsenic Contamination in Asia
Kumagai, Yoshito;Yumi, Abiko (Part:Contributor, Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic)
Springer, Singapore   Dec 2018   ISBN:9789811325649
熊谷嘉人 (Part:Contributor, RSSによる環境中親電子物質の解毒代謝)
Apr 2015   
安孫子, ユミ;熊谷, 嘉人 (Part:Contributor, 地球規模におけるヒ素汚染の現状)
Jul 2010   
熊谷,嘉人 (Part:Contributor, 親電子シグナル伝達)
Sep 2009   
National Institute on Drug Abuse Monograph
Cho,AK;Hiramatsu,M;Kumagai,Y;Patel,N (Part:Contributor, Pharmacokinetic approach to the study of durg action and toxicology)
Jan 1992   

Conference Activities & Talks

Activation of redox signal transduction pathways mediated by electrophilic metals [Invited]
10th Congress of Toxicology in Developing Countries   Apr 2018   
環境中親電子物質エクスポソームと防御応答・適応 [Invited]
生理学研究所 研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」   Apr 2018   
エクスポソームと生命環境応答・適応 [Invited]
第71回日本酸化ストレス学会・第18回日本NO学会合同学術集会   May 2018   
Environmental electrophiles and reactive sulfur species: implications to regulation of redox signaling and toxicity [Invited]
The 8th International Congress of Asian Society of Toxicology   Jun 2018   
Electrophilic stress: Good or bad? [Invited]
The 6th Conference of the Japanese Association for Hypoxia Biology International Symposium for Innovative Areas "Oxygen Biology" and New Insights into Ion Channel Functions and Pharmacology​​   Jul 2018