論文

査読有り
2014年12月

One-year follow-up of zoster-associated pain in 764 immunocompetent patients with acute herpes zoster treated with famciclovir (FAMILIAR study)

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
  • S. Imafuku
  • ,
  • J. Nakayama
  • ,
  • K. Higa
  • ,
  • M. Furue
  • ,
  • M. Takahara
  • ,
  • I. Katayama
  • ,
  • M. Tani

28
12
開始ページ
1716
終了ページ
1722
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/jdv.12379
出版者・発行元
WILEY-BLACKWELL

BackgroundHerpes zoster (HZ), a reactivation of varicella zoster virus manifested by skin blisters and neuralgia, can lead to postherpetic neuralgia in 10-20% of affected subjects.
MethodIn this study, a cohort of 764 patients with HZ was treated with 1500mg/day of famciclovir for 7days, and zoster-associated pain (ZAP) was monitored monthly thereafter for up to 12months until pain resolution was achieved. Patients were questioned monthly by telephone, and pain was recorded using a numerical rating scale (NRS, 0-10).
Key resultsA total of 751 of 764 (98.3%) patients completed follow-up. The percentage of patients with ZAP was 12.4% at day 90, 7.1% at 6months and 4.0% at 1year. After the third month, the NRS were 3 or less in most of the remaining patients with ZAP. Stratified analysis revealed significant persistence of ZAP in patients aged 50years and in those aged 65years, and in patients with either moderate-to-severe skin symptoms or severe pain at the initial consultation. Stratified analyses unexpectedly showed patients who commenced famciclovir at 0-2days after onset of the eruption had a higher prevalence of ZAP at day 90 than those treated at 3-5days or 6days after rash onset (P=0.0164, log-rank test). On further analysis, a higher proportion of patients (45.4%) treated at 0-2days had moderate to severe symptoms compared with those treated at 3-5days (40.5%) or 6days (37.0%) (P=0.0987, Cochran-Armitage test).
Conclusion & InferenceThis study, with an exceptionally high follow-up rate, revealed several new findings, including the influence of disease severity on the delay between the onset of symptoms and seeking medical attention. Six adverse drug reactions were reported in five of 721 patients in the safety analysis, including two severe cases of vomiting and convulsions.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1111/jdv.12379
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000345348800016&DestApp=WOS_CPL

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