2017年10月
Fabrication of poly(ethylene glycol) hydrogels containing vertically and horizontally aligned graphene using dielectrophoresis: An experimental and modeling study
CARBON
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- 巻
- 123
- 号
- 開始ページ
- 460
- 終了ページ
- 470
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.carbon.2017.07.082
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
We incorporated bovine serum albumin (BSA)-functionalized graphene in poly(ethylene glycol) diacrylate (PEG) hydrogels. The graphene alignment in PEG hydrogels was changed using dielectrophoresis (DEP) forces. Effect of graphene concentration (2.55 and 5.1 mg/mL) and alignment (vertical and horizontal) on electrical and mechanical properties of hybrid graphene-PEG gels was evaluated. In addition, the molecular interaction of BSA peptides with graphene in the presence and absence of an electric field was assessed. The incorporation of graphene in PEG improved mechanical properties of hybrid gels. Dielectrophoretically aligned graphene-PEG hydrogels showed an anisotropic electrical conductivity. Young's modulus of 5.1 mg/mL graphene-PEG was almost three times higher than that of pristine PEG. Viability and proliferation of mouse embryonic stem cells on graphene-PEG gels were comparable with control PEG hydrogels. Ab initio calculations showed longer peptides had higher binding affinity towards graphene and caused a change in dipole moment due to the presence of electric field. The electric field also expanded graphene and peptide chains, which confirms the graphene alignment using DEP forces. Hybrid aligned graphene-PEG hydrogels may serve as functional biomaterials to engineer biological tissues and fabricate biomedical devices. (C) 2017 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.carbon.2017.07.082
- ISSN : 0008-6223
- eISSN : 1873-3891
- ORCIDのPut Code : 37933594
- Web of Science ID : WOS:000410369600054
- ORCIDで取得されたその他外部ID : a:1:{i:0;a:1:{s:8:"other-id";s:19:"WOS:000410369600054";}}