2021年4月1日
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease
American Journal of Physiology-Gastrointestinal and Liver Physiology
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- 巻
- 320
- 号
- 4
- 開始ページ
- G464
- 終了ページ
- G473
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1152/ajpgi.00120.2020
- 出版者・発行元
- American Physiological Society
This study indicates that metformin, an indirect AMPK activator slows liver cyst formation and fibrosis in PLD rat model. Metformin attenuates excessive cell proliferation in the liver with the inactivation of mTOR and ERK pathways. Metformin also reduces the expression of proteins responsible for cystic fluid secretion and liver fibrosis. Metformin and AMPK activators may be potent drugs for polycystic liver disease.
- リンク情報
- ID情報
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- DOI : 10.1152/ajpgi.00120.2020
- ISSN : 0193-1857
- eISSN : 1522-1547
- PubMed ID : 33439105