2017年12月
Humanin affects object recognition and gliosis in short-term cuprizone-treated mice
NEUROPEPTIDES
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- ,
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- 巻
- 66
- 号
- 開始ページ
- 90
- 終了ページ
- 96
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.npep.2017.10.002
- 出版者・発行元
- CHURCHILL LIVINGSTONE
Humanin (HN) is a 24-residue peptide that manipulates cell survival under various stresses. A highly potent HN derivative, HNG, reduced amyloid burden and neuroinflammation and suppressed cognitive impairment in Alzheimer's disease model mice. Cuprizone (CPZ), a copper chelator, provokes demyelination in the central nervous system of mice. A shorter (one week) exposure to CPZ induces schizophrenia-like behavior and glial activation prior to demyelination. We tested the effect of HNG on these short-term responses to CZP in mice. Intraperitoneal injection of HNG for one week improved object recognition memory but not working memory in CPZ-treated mice. Quantitative PCR analyses showed that HNG significantly suppressed CPZ-induced activation of microglia, but did not alter the reduced level of a myelin-specific transcript. These results suggest that HN can suppress neuroinflammation and the associated cognitive deficit in a wider range of neurological disorders beyond Alzheimer's disease.
- リンク情報
- ID情報
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- DOI : 10.1016/j.npep.2017.10.002
- ISSN : 0143-4179
- eISSN : 1532-2785
- PubMed ID : 24971881
- Web of Science ID : WOS:000416499000011