Matsuo, Koichi

J-GLOBAL         Last updated: May 29, 2019 at 02:59
Matsuo, Koichi
Keio University
School of Medicine Collaborative Research Resources (Laboratory of Cell and Tissue Biology)
Job title
M.D., Ph.D.(Keio University)
Research funding number

Research Areas


Academic & Professional Experience

Apr 2001
Mar 2002
Chief, Chief, National Institute for Longevity Sciences
Apr 2002
Mar 2007
Associate professor, Department of Microbiology and Immunology, Associate Professor, School of Medicine, Keio University
Apr 2007
May 2009
Associate Professor, Department of Microbiology and Immunology, Keio University School of Medicine
Jun 2009
Professor, Laboratory of Cell and Tissue Biology, Keio University School of Medicine
Oct 2009


Mar 1990
Graduate School of Medicine, Keio University

Awards & Honors

Jul 2014
Distinguished Scientist Award, Japanese Society for Bone and Mineral Research
Jun 2003
Kitasato Award, Keio University School of Medicine
Sep 1997
Young Investigator Award, American Society for Bone and Mineral Research

Published Papers

Sasaki Mamoru, Chubachi Shotaro, Kameyama Naofumi, Sato Minako, Haraguchi Mizuha, Miyazaki Masaki, Takahashi Saeko, Nakano Takayoshi, Kuroda Yukiko, Betsuyaku Tomoko, Matsuo Koichi
PLoS One   13(1)    Jan 2018
<p>Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health...
Matsui Hidenori, Takahashi Tetsufumi, Murayama Somay Y., Kawaguchi Marina, Matsuo Koichi, Nakamura Masahiko
Helicobacter   22(6)    Dec 2017
<p>Background: We have previously revealed that omega-3 polyunsaturated fatty acids can prevent Helicobacter pylori infection by blocking the futalosine pathway, an alternative route for menaquinone (MK) biosynthesis. Materials and Methods: 1, Dif...
Yang Mengyu, Arai Atsushi, Udagawa Nobuyuki, Hiraga Toru, Lijuan Zhao, Ito Susumu, Komori Toshihisa, Moriishi Takeshi, Matsuo Koichi, Shimoda Kouji, Zahalka Ali H., Kobayashi Yasuhiro, Takahashi Naoyuki, Mizoguchi Toshihide
Scientific Reports   7(1)    Dec 2017
<p>Bone marrow mesenchymal stem and progenitor cells (BM-MSPCs) maintain homeostasis of bone tissue by providing osteoblasts. Although several markers have been identified for labeling of MSPCs, these labeled cells still contain non-BM-MSPC popula...
Sakamoto Ayako, Kuroda Yukiko, Kanzaki Sho, Matsuo Koichi
Journal of Visualized Experiments   2017(119)    Jan 2017
<p>In most mammals, auditory ossicles in the middle ear, including the malleus, incus and stapes, are the smallest bones. In mice, a bony structure called the auditory bulla houses the ossicles, whereas the auditory capsule encloses the inner ear,...
Kamel Walied A., Sugihara Eiji, Nobusue Hiroyuki, Yamaguchi-Iwai Sayaka, Onishi Nobuyuki, Maki Kenta, Fukuchi Yumi, Matsuo Koichi, Muto Akihiro, Saya Hideyuki, Shimizu Takatsune
Molecular Cancer Therapeutics   16(1) 182-192   Jan 2017
<p>Osteosarcoma is the most common type of primary bone tumor, novel therapeutic agents for which are urgently needed. To identify such agents, we screened a panel of approved drugs with a mouse model of osteosarcoma. The screen identified simvast...


Bone Cell Biology Assessed by Microscopic Approach. Regulation of bone mineralization through the osteocyte lacuno-canalicular network
Matsuo Koichi
Clinical calcium   25(10) 1461-1466   Oct 2015
<p>Osteocytes and their dendrites form a large network called the lacuno-canalicular system in mammalian bone. Osteocytes are believed to directly contribute to regulation of mineralization and demineralization in bone matrix, in addition to their...
Matsuo Koichi
Clinical calcium   24(9) 1337-1342   Sep 2014   [Invited]
[Osteoimmunologic regulation of aging].
Matsuo Koichi
Clinical calcium   23(1) 59-64   Jan 2013
<p>In bones, aging manifests itself as a shift towards production of myeloid cells in bone marrow, a condition associated with increased chronic inflammation by macrophages and decreased bone mass due to excess bone resorption by osteoclasts. An i...
Regulation of bone metabolism by Eph-ephrin family members
Matsuo K、, Otaki N
Clinical calcium   22(11) 1669-1675   Nov 2012   [Invited]
[Osteocytic osteolysis
Matsuo Koichi, Nango Nobuhito
Clinical calcium   22(5) 677-683   May 2012
<p>Osteocytes are present in osteocytic lacunae in both cortical and trabecular bone, where they are interconnected by numerous dendrites in osteocytic canaliculi. In mammals, osteocytes are the most abundant bone cells, outnumbering osteoclasts a...

Conference Activities & Talks

Mammalian-type Brn-1/Pou3f3 with 'homopolymeric amino acids (HPAAs)' is essential for stress-induced bone metabolic changes in mice [Invited]
Igarashi Atsushi, Matsuo Koichi, Ueda Shintaroh
Australian New Zealand Bone & Mineral Society Annual Scientific Meeting   1 Nov 2015   
Sialylated Glycans of MMP-9 Marak Bone Resorption Lacunae.
Kuroda Yukiko, Kuno Atsushi, Narimatsu Hisashi,Matsuo Koichi
Annual Meeting of the American Society for Bone and Mineral Research   11 Oct 2015   
Seasonality in Bone Mineralization of Auditory Ossicles and Long Bones in the Primate Macaca fuscata
Matsuo Koichi
Annual Meeting of the American Society for Bone and Mineral Research   11 Oct 2015   
Continuous Parathyroid Hormone Injection in Mouse Has Differential Effects on Osteoclast Activation in Primary and Secondary Spongiosa.
Nango Nobuhito, Kubota Shogo, Yashiro Wataru, Momose Atsushi, Ichinose Shizuko,Matsuo Koichi
Annual Meeting of the American Society for Bone and Mineral Research   10 Oct 2015   
EphB/ephrin-B interactions regulate stromal cell fate determination and bone marrow support
Matsuo Koichi
Annual Meeting of the American Society for Bone and Mineral Research   9 Oct 2015   

Teaching Experience


Research Grants & Projects

Osteogenic capillaries - new aspect of endochondral ossification
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2021    Investigator(s): 松尾 光一


PCT/JP2006/309602 : 炎症性疾患の検出並びに炎症性疾患の予防又は治療用組成物