論文

2019年1月1日

APOE Alleles and extreme human longevity

Journals of Gerontology - Series A Biological Sciences and Medical Sciences
  • Sebastiani P
  • Gurinovich A
  • Nygaard M
  • Sasaki T
  • Sweigart B
  • Bae H
  • Andersen S
  • Villa F
  • Atzmon G
  • Christensen K
  • Arai Y
  • Barzilai N
  • Puca A
  • Christiansen L
  • Hirose N
  • Perls T
  • 全て表示

74
1
開始ページ
44
終了ページ
51
DOI
10.1093/gerona/gly174
出版者・発行元
Journals of Gerontology - Series A Biological Sciences and Medical Sciences

© 2018 The Author(s). Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. We assembled a collection of 28,297 participants from seven studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity, and the Health and Retirement Studies to investigate the association between the APOE alleles ϵ 2 ϵ 3 and ϵ 4 and extreme human longevity and age at death. By using three different genetic models and two definitions of extreme longevity based on either a threshold model or age at death, we show that ϵ 4 is associated with a substantially decreased odds for extreme longevity, and increased risk for death that persists even beyond ages reached by less than 1% of the population. We also show that carrying the ϵ 2 ϵ 2 or ϵ 2 ϵ 3 genotype is associated with significantly increased odds to reach extreme longevity, with decreased risk for death compared with carrying the genotype ϵ 3 ϵ 3 but with only a modest reduction in risk for death beyond an age reached by less than 1% of the population.

リンク情報
DOI
https://doi.org/10.1093/gerona/gly174
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058571306&origin=inward
ID情報
  • DOI : 10.1093/gerona/gly174
  • ISSN : 1079-5006

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