Yamagishi, Hiroyuki

J-GLOBAL         Last updated: May 29, 2019 at 03:24
 
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Name
Yamagishi, Hiroyuki
E-mail
hyamagkeio.jp
Affiliation
Keio University
Section
School of Medicine Department of Pediatrics
Job title
Professor
Degree
博士(医学)(Keio University)
Research funding number
40255500

Research Areas

 
 

Education

 
Apr 1989
 - 
Mar 1993
医学研究科内科系小児科学, School of Medicine, Keio University
 

Awards & Honors

 
2012
先天性心疾患の発症分子機構解明と臨床心臓発生学の発展, 高尾賞, 日本小児循環器学会
 
2011
心臓血管発生と先天性心疾患発症の分子機構の解明, 三四会賞(北里・北島賞)北島賞, 慶應義塾大学
 
Jul 2003
円錐動脈幹の発生における転写因子Tbx1の発現, 学会会長賞, 第39回日本小児循環器学会学術集会
 
May 2003
Tbx1 is regulated by tissue-specific forkhead proteins through a common sonic hedgehog-responsive enhancer, Richard D. Rowe Award in Perinatal Cardiology, Society of Pediatric Research
 
2003
転写因子Tbx1の組織特異的転写制御機構の解明, 三四会奨励賞, 慶應義塾大学
 

Published Papers

 
Pulmonary arterial hypertension associated with tetralogy of Fallot
Yasuhara Jun, Yamagishi Hiroyuki
International heart journal   56 S17-S21   Mar 2015
<p>Pulmonary arterial hypertension (PAH) is a common postoperative complication in patients with congenital heart disease (CHD). Although the recent clinical classification of pulmonary hypertension divided PAH associated with CHD (PAH–CHD) into s...
Arita Yoh, Nakaoka Yoshikazu, Matsunaga Taichi, Kidoya Hiroyasu, Yamamizu Kohei, Arima Yuichiro, Kataoka-Hashimoto Takahiro, Ikeoka Kuniyasu, Yasui Taku, Masaki Takeshi, Yamamoto Kaori, Higuchi Kaori, Park Jin Sung, Shirai Manabu, Nishiyama Koichi, Yamagishi Hiroyuki, Otsu Kinya, Kurihara Hiroki, Minami Takashi, Yamauchi-Takihara Keiko, Koh Gou Y., Mochizuki Naoki, Takakura Nobuyuki, Sakata Yasushi, Yamashita Jun K., Komuro Issei
Nature Communications   5    Jul 2014
<p>The origin and developmental mechanisms underlying coronary vessels are not fully elucidated. Here we show that myocardium-derived angiopoietin-1 (Ang1) is essential for coronary vein formation in the developing heart. Cardiomyocyte-specific An...
Muraoka Naoto, Yamakawa Hiroyuki, Miyamoto Kazutaka, Sadahiro Taketaro, Umei Tomohiko, Isomi Mari, Nakashima Hanae, Akiyama Mizuha, Wada Rie, Inagawa Kohei, Nishiyama Takahiko, Kaneda Ruri, Fukuda Toru, Takeda Shu, Tohyama Shugo, Hashimoto Hisayuki, Kawamura Yoshifumi, Goshima Naoki, Aeba Ryo, Yamagishi Hiroyuki, Fukuda Keiichi, Ieda Masaki
EMBO Journal   33(14) 1565-1581   Jul 2014
<p>Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by overexpression of cardiac transcription factors or microRNAs. However, induction of functional cardiomyocytes is inefficient, and molecular mechanisms of direct re...
Shiraishi Isao, Nishimura Kunihiro, Sakaguchi Heima, Abe Tadaaki, Kitano Masataka, Kurosaki Kenichi, Kato Hitoshi, Nakanishi Toshio, Yamagishi Hiroyuki, Sagawa Koichi, Ikeda Yoshihiko, Morisaki Takayuki, Hoashi Takaya, Kagisaki Koji, Ichikawa Hajime
Circulation   130(13) 1053-1061   2014
<p>Background: Recently, infant cases of acute heart failure attributable to rupture of the mitral chordae tendineae have been reported. However, little is known about the pathogenesis and clinical course of this condition. Methods and Results-Nin...
Fukushima H., Mitsuhashi T., Oto T., Sano Y., Kusano K. F., Goto K., Okazaki M., Date H., Kojima Y., Yamagishi H., Takahashi T.
American Journal of Transplantation   13(12) 3278-3281   Dec 2013
<p>Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic tel...
Yamagishi Hiroyuki, Yamagishi Chihiro
7-21   Nov 2013
<p>The heart is the first organ that is formed and becomes functional in the human embryo. It bears the circulatory system from the early embryonic period and alters its morphology to each stage of an embryonic growth according to its demand. The ...
Wada Rie, Muraoka Naoto, Inagawa Kohei, Yamakawa Hiroyuki, Miyamoto Kazutaka, Sadahiro Taketaro, Umei Tomohiko, Kaneda Ruri, Suzuki Tomoyuki, Kamiya Kaichiro, Tohyama Shugo, Yuasa Shinsuke, Kokaji Kiyokazu, Aeba Ryo, Yozu Ryohei, Yamagishi Hiroyuki, Kitamura Toshio, Fukuda Keiichi, Ieda Masaki
Proceedings of the National Academy of Sciences of the United States of America   110(31) 12667-12672   Jul 2013
<p>Heart disease remains a leading cause of death worldwide. Owing to the limited regenerative capacity of heart tissue, cardiac regenerative therapy has emerged as an attractive approach. Direct reprogramming of human cardiac fibroblasts (HCFs) i...
Gatayama Ryohei, Ueno Kentaro, Nakamura Hideaki, Yanagi Sadamitsu, Ueda Hideaki, Yamagishi Hiroyuki, Yasui Seiyo
Pediatrics   131(6)    Jun 2013
<p>We present a case of a 9-year-old boy with nemaline myopathy and dilated cardiomyopathy. The combination of nemaline myopathy and cardiomyopathy is rare, and this is the first reported case of dilated cardiomyopathy associated with childhood-on...
Shinjoh Masayoshi, Iketani Osamu, Watanabe Kota, Shimojima Naoki, Kudo Mikihiko, Yamagishi Hiroyuki, Shimada Hiroyuki, Sugita Kayoko, Takahashi Takao, Mori Takehiko, Hasegawa Naoki, Iwata Satoshi
Journal of Infection and Chemotherapy   18(4) 591-596   Aug 2012
<p>Linezolid, an oxazolidinone antibiotic, exhibits a broad spectrum of activity against Gram-positive bacteria. It hasbeen licensed for adult use in Japan since 2006 for MRSA infections, and has also been used off-label for pediatric patients.At ...
Takagaki Yohtaroh, Yamagishi Hiroyuki, Matsuoka Rumiko
International Review of Cell and Molecular Biology   296 187-272   2012
<p>Muscle is a contractile tissue of animals, dedicated to produce force and cause motion. In higher animals, there are two types of muscle tissue: (a) striated muscle, including all voluntary skeletal muscles and involuntary cardiac muscle, and (...
Kodo Kazuki, Nishizawa Tsutomu, Furutani Michiko, Arai Shoichi, Ishihara Kazuaki, Oda Mayumi, Makino Shinji, Fukuda Keiichi, Takahashi Takao, Matsuoka Rumiko, Nakanishi Toshio, Yamagishi Hiroyuki
Circulation Journal   76(7) 1703-1711   2012
<p>Background: The genetic basis of most congenital heart defects (CHDs), especially non-syndromic and non-familial conditions, remains largely unknown. Methods and Results: DNA samples were collected from immortalized cell lines and original geno...
Maeda Jun, Yamagishi Hiroyuki, Furutani Yoshiyuki, Kamisago Mitsuhiro, Waragai Tadashi, Oana Shinji, Kajino Hiroki, Matsuura Hiroyuki, Mori Katsuhiko, Matsuoka Rumiko, Nakanishi Toshio
American Journal of Medical Genetics, Part A   155(11) 2641-2646   Nov 2011
<p>Congenital heart defects (CHD) are very common in patients with trisomy 18 (T18) and trisomy 13 (T13). The surgical indication of CHD remains controversial since the natural history of these trisomies is documented to be poor. To investigate th...
Kodo Kazuki, Yamagishi Hiroyuki
Circulation Journal   75(10) 2296-2304   Oct 2011
<p>Congenital heart defects (CHD) are the most common type of human birth defect and result in significant mortality worldwide. Despite numerous epidemiologic studies in the past decades, few genetic causes have been identified until recently. CHD...
Nakazawa Maki, Uchida Keiko, Aramaki Megumi, Kodo Kazuki, Yamagishi Chihiro, Takahashi Takao, Mikoshiba Katsuhiko, Yamagishi Hiroyuki
Journal of Molecular and Cellular Cardiology   51(1) 58-66   Jul 2011
<p>Congenital heart defects (CHDs) occur in 0.5-1% of live births, yet the underlying genetic etiology remains mostly unknown. Recently, a new source of myocardial cells, namely the second heart field (SHF), was discovered in the splanchnic mesode...
Tsuchihashi Takatoshi, Maeda Jun, Shin Chong H., Ivey Kathryn N., Black Brian L., Olson Eric N., Yamagishi Hiroyuki, Srivastava Deepak
Developmental Biology   351(1) 62-69   Mar 2011
<p>Cardiogenesis involves the contributions of multiple progenitor pools, including mesoderm-derived cardiac progenitors known as the first and second heart fields. Disruption of genetic pathways regulating individual subsets of cardiac progenitor...
Li Quanxi, Kannan Athilakshmi, DeMayo Francesco J., Lydon John P., Cooke Paul S., Yamagishi Hiroyuki, Srivastava Deepak, Bagchi Milan K., Bagchi Indrani C.
Science   331(6019) 912-916   Feb 2011
<p>During pregnancy, progesterone inhibits the growth-promoting actions of estrogen in the uterus. However, the mechanism for this is not clear. The attenuation of estrogen-mediated proliferation of the uterine epithelium by progesterone is a prer...
Kodo Kazuki, Yamagishi Hiroyuki
Journal of Human Genetics   55(10) 637-638   Oct 2010
Fukushima Hiroyuki, Kosaki Kenjiro, Sato Reiko, Yagihashi Tatsuhiko, Gatayama Ryohei, Kodo Kazuki, Hayashi Takuya, Nakazawa Maki, Tsuchihashi Takatoshi, Maeda Jun, Kojima Yoshifumi, Yamagishi Hiroyuki, Takahashi Takao
American Journal of Medical Genetics, Part A   152(8) 1919-1924   Aug 2010
<p>Patients with Down syndrome (DS) and a left-to-right shunt often develop early severe pulmonary hypertension (PH) and pulmonary vascular obstructive disease (PVOD); the pathophysiological mechanisms underlying the development of these complicat...
Yamagishi Hiroyuki
General Thoracic and Cardiovascular Surgery   58(5) 217-219   May 2010
Uchida Keiko, Aramaki Megumi, Nakazawa Maki, Yamagishi Chihiro, Makino Shinji, Fukuda Keiichi, Nakamura Takeshi, Takahashi Takao, Mikoshiba Katsuhiko, Yamagishi Hiroyuki
PLoS ONE   5(9) 1-10   2010
<p>Background: Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulatevarious vital processes. Although the ryanodine receptor type 2, another type of intracellular Ca<su...

Misc

 
ここまで知っておきたい発生学 左右軸の決定と内臓錯位症候群
山岸 敬幸
日本小児循環器学会雑誌   34(3) 99-104   Sep 2018
先天性心疾患は、心臓大血管の発生における特定の領域または段階の異常によって発症する。発生初期の胚は、心臓の原基を含めて左右対称の形態をしている。体の各臓器・組織が正常に左右非対称に形成されるためには、体の左右軸に関する情報が必要である。左右軸が決定される過程は、次のように説明される:Nodeのciliaが回転運動し、Nodal flowが生じることにより胚の右から左への分子の流れが発生する;その流れが胚の左側に左側形成機構を誘導し左側形成分子・遺伝子カスケード、すなわちTGF-βスーパーフ...
大動脈肺動脈窓、心室中隔欠損症の1例
宮武 瑛里, 山手 和智, 大河原 一郎, 西澤 和倫, 前田 潤, 山岸 敬幸, 田中 靖彦
日本小児科学会雑誌   122(9) 1492-1493   Sep 2018
心室中隔欠損症後肺高血圧から先天性門脈体循環シャントと診断された21 trisomyの1例
山本 一希, 多喜 萌, 安原 潤, 前田 潤, 福島 裕之, 山岸 敬幸, 高橋 孝雄
日本小児科学会雑誌   122(8) 1381-1381   Aug 2018
【おさえたい診療ガイドラインのツボ-小児循環器編-】 各診療ガイドラインのポイント RSウイルス感染重症化予防
多喜 萌, 山岸 敬幸
小児科診療   81(7) 925-929   Jul 2018
●先天性心疾患児のRSV感染重症化予防の手段として、2005年10月にパリビズマブが承認、ガイドラインが作成され、効果をあげている。●「適応」の鍵となる文言は、「明らかに循環動態の異常を示す」である。●ガイドライン作成後10年以上が経過し、最近の動向に合わせて見直しの時期がきている。●パリビズマブの除外基準、考慮されるべきリスク因子、投与開始時期と投与期間などが、今後のポイントとなる。(著者抄録)
成人先天性心疾患の成因・遺伝
山岸 敬幸, 石崎 怜奈, 岩下 憲行
循環器内科   83(5) 479-486   May 2018

Conference Activities & Talks

 
Molecular mechanisms regulating tissue-specific _expression of Tbx1 [Invited]
Yamagishi H
Symposium on Etiology and Morphogenesis of Congenital Cardiovascular Disease in the Post-genomic Era   Dec 2002   
Tissue-specific regulatory elements of Tbx1, a del.22q11 candidate gene, reveal a molecular cascade involved in pharyngeal arch development
Yamagishi H, Maeda J, Hu T, McAnally J, Yamagishi C, Srivastava D
Scientific Sessions of American Heart Association   Nov 2002   
Tbx1 is regulated by forkhead proteins through a sonic hedgehog-responsive enhancer [Invited]
Maeda J, Yamagishi H, Srivastava D
Society for Developmental Biology Southwest & Gulf Regional Meeting   Sep 2002   
Tissue-specific regulation of Tbx1 during cardiovascular and pharyngeal arch development
Yamagishi H, Maeda J, Tonghuan Hu, Yamagishi C, Srivastava D
Weinstein Cardiovascular Development Conference   May 2002   
Sonic hedgehog is essential for first pharyngeal arch development
Maeda J, Yamagishi C, Yamagishi H, Srivastava D
Weinstein Cardiovascular Development Conference   May 2002   

Teaching Experience

 

Works

 
EEP小委員会委員
The Others   Oct 2003 - Sep 2005

Research Grants & Projects

 
T-box遺伝子ファミリー機能解析による先天性心血管疾患発症機構の解明
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2019    Investigator(s): 山岸 敬幸
動物モデルを用いた先天性心臓流出路異常の予防と新たな治療への基礎的研究(基盤B)
Grant-in-Aid for Scientific Research
Project Year: 2013 - 2015
心臓流出路を形成する細胞の発生分化と相互作用を制御する分子機構(基盤B)
Grant-in-Aid for Scientific Research
Project Year: 2010 - 2012
細胞内カルシウムシグナル伝達による心臓発生の領域別制御とその分子機構の解明(基盤B)
Grant-in-Aid for Scientific Research
Project Year: 2007 - 2009
心臓流出路の発生における前方心臓領域細胞と転写因子Tbx1の機能(基盤C)
Grant-in-Aid for Scientific Research
Project Year: 2005 - 2006