1997年
巣状・微小メサンギウム増殖を示す小児期IgA腎症における柴苓湯治療のプロスペクティブコントロールスタディ
日腎会誌
- 巻
- 39
- 号
- 5
- 開始ページ
- 503
- 終了ページ
- 506
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.14842/jpnjnephrol1959.39.503
- 出版者・発行元
- Japanese Society of Nephrology
To determine the effect of the Chinese herbal medicine, Sairei-to (TJ-114) in children with newly diagnosed IgA nephropathy showing focal/minimal mesangial proliferation, we undertook a prospective controlled study. One hundred and one patients were randomly assigned to receive Sairei-to for 2 years (group 1) or no drug for 2 years (group 2) . Forty-six of the 50 patients in group 1 and 48 of the 51 patients in group 2 completed their trial. At entry, the two groups of patients did not differ in their clinical, laboratory and pathologic findings. At the end of the trial, urinary protein excretion and hematuria were significantl y reduced in group 1, but were unchanged in group 2. Twenty-one group 1 patients (46%) had normal urine, but only 5 group 2 patients (10%) had normal urine at the end of the trial (p<0.001). Blood pressure and creatinine clearance were normal at the end of the trial in all but one group 2 patient, who developed chronic renal failure. The present study demonstrates that 2-year Sairei-to treatment early in the course of disease is effective in children with IgA nephropathy showing focal/minimal mesangial proliferation.
- リンク情報
- ID情報
-
- DOI : 10.14842/jpnjnephrol1959.39.503
- ISSN : 0385-2385
- CiNii Articles ID : 130004170393