We examined body core and skin temperatures and thermal comfort in young Japanese women suffering from unusual coldness (C, n=6). They were selected by interview asking whether they often felt severe coldness even in an air-conditioned environment (20-26degreesC) and compared with women not suffering from coldness (N, n=6). Experiments were conducted twice for each subject: 120-min exposure at 23.5degreesC or 29.5degreesC after a 40-min baseline at 29.5degreesC. Mean skin temperature decreased (P<0.05) from 33.6±0.1°C (mean ± SE) to 31.1±0.1°C and from 33.5±0.1°C to 31.1±0.1°C in C and N during the 23.5°C exposure. Fingertip temperature in C decreased more than in N (P<0.05; from 35.2+/-0.1degreesC to 23.6+/-0.2degreesC and from 35.5+/-0.1degreesC to 25.6+/-0.6degreesC). Those temperatures during the 29.5degreesC exposure remained at the baseline levels. Rectal temperature during the 23.5degreesC exposure was maintained at the baseline level in both groups (from 36.9+/-0.2degreesC to 36.8+/-0.1degreesC and 37.1+/-0.1degreesC to 37.0+/-0.1degreesC in C and N). The rating scores of cold discomfort for both the body and extremities were greater (P<0.05) in C than in N. Thus the augmented thermal sensitivity of the body to cold and activated vasoconstriction of the extremities during cold exposure could be the mechanism for the severe coldness felt in C.