2021年3月26日
Universal Relation between Instantaneous Diffusivity and Radius of Gyration of Proteins in Aqueous Solution.
Physical review letters
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- ,
- ,
- 巻
- 126
- 号
- 12
- 開始ページ
- 128101
- 終了ページ
- 128101
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1103/PhysRevLett.126.128101
Protein conformational fluctuations are highly complex and exhibit long-term correlations. Here, molecular dynamics simulations of small proteins demonstrate that these conformational fluctuations directly affect the protein's instantaneous diffusivity D_{I}. We find that the radius of gyration R_{g} of the proteins exhibits 1/f fluctuations that are synchronous with the fluctuations of D_{I}. Our analysis demonstrates the validity of the local Stokes-Einstein-type relation D_{I}∝1/(R_{g}+R_{0}), where R_{0}∼0.3 nm is assumed to be a hydration layer around the protein. From the analysis of different protein types with both strong and weak conformational fluctuations, the validity of the Stokes-Einstein-type relation appears to be a general property.
- リンク情報
- ID情報
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- DOI : 10.1103/PhysRevLett.126.128101
- PubMed ID : 33834804