1995年10月
INCREASE IN CYSTINE TRANSPORT ACTIVITY AND GLUTATHIONE LEVEL IN MOUSE PERITONEAL-MACROPHAGES EXPOSED TO OXIDIZED LOW-DENSITY-LIPOPROTEIN
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ,
- ,
- ,
- ,
- ,
- 巻
- 215
- 号
- 1
- 開始ページ
- 154
- 終了ページ
- 159
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1006/bbrc.1995.2446
- 出版者・発行元
- ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
The transport of cystine has been investigated in mouse peritoneal macrophages incubated with oxidized low-density lipoprotein (oxi-LDL; low-density lipoprotein, LDL). The transport activity for cystine was potently induced by oxi-LDL but not by native or acetylated LDL. The response of the cells to oxi-LDL was dependent on the extent of oxidative modification of LDL. The transport activity for other amino acids was not induced by oxi-LDL. GSH content increased in macrophages incubated with oxi-LDL and this increase was accounted for by the induction of the cystine transport activity because the increase was completely blocked by glutamate or homocysteate which shared the transport system for cystine and thus inhibited the uptake of cystine competitively. (C) 1995 Academic Press, Inc.
- リンク情報
- ID情報
-
- DOI : 10.1006/bbrc.1995.2446
- ISSN : 0006-291X
- Web of Science ID : WOS:A1995RY30800021