論文

査読有り
1995年10月

INCREASE IN CYSTINE TRANSPORT ACTIVITY AND GLUTATHIONE LEVEL IN MOUSE PERITONEAL-MACROPHAGES EXPOSED TO OXIDIZED LOW-DENSITY-LIPOPROTEIN

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • H SATO
  • ,
  • Y TAKENAKA
  • ,
  • K FUJIWARA
  • ,
  • M YAMAGUCHI
  • ,
  • K ABE
  • ,
  • S BANNAI

215
1
開始ページ
154
終了ページ
159
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1006/bbrc.1995.2446
出版者・発行元
ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS

The transport of cystine has been investigated in mouse peritoneal macrophages incubated with oxidized low-density lipoprotein (oxi-LDL; low-density lipoprotein, LDL). The transport activity for cystine was potently induced by oxi-LDL but not by native or acetylated LDL. The response of the cells to oxi-LDL was dependent on the extent of oxidative modification of LDL. The transport activity for other amino acids was not induced by oxi-LDL. GSH content increased in macrophages incubated with oxi-LDL and this increase was accounted for by the induction of the cystine transport activity because the increase was completely blocked by glutamate or homocysteate which shared the transport system for cystine and thus inhibited the uptake of cystine competitively. (C) 1995 Academic Press, Inc.

リンク情報
DOI
https://doi.org/10.1006/bbrc.1995.2446
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1995RY30800021&DestApp=WOS_CPL
ID情報
  • DOI : 10.1006/bbrc.1995.2446
  • ISSN : 0006-291X
  • Web of Science ID : WOS:A1995RY30800021

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