1995年5月
INDUCTION OF STRESS PROTEINS IN MOUSE PERITONEAL-MACROPHAGES BY THE ANTIRHEUMATIC AGENTS GOLD SODIUM THIOMALATE AND AURANOFIN
BIOCHEMICAL PHARMACOLOGY
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- 巻
- 49
- 号
- 10
- 開始ページ
- 1453
- 終了ページ
- 1457
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/0006-2952(95)00033-V
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Gold sodium thiomalate and auranofin, anti-rheumatic gold-containing compounds, induced some stress proteins in cultured mouse peritoneal macrophages. The enhanced synthesis of two proteins, heme oxygenase (a 34-kDa protein) and a 23-kDa protein, was particularly prominent. The 23-kDa protein induced by the gold compounds was identical to that found in macrophages exposed to oxidative stress and was suggested to have antioxidant activity. Intraperitoneal injection of gold sodium thiomalate and oral administration of auranofin to mice induced enhanced synthesis of these proteins in peritoneal macrophages analyzed ex vivo. These data suggest that increased synthesis of these proteins may have a role in mediating the pharmacologic effect of these agents.
- リンク情報
- ID情報
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- DOI : 10.1016/0006-2952(95)00033-V
- ISSN : 0006-2952
- Web of Science ID : WOS:A1995RA12400015