2008年10月
Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats
NEUROREPORT
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- 巻
- 19
- 号
- 16
- 開始ページ
- 1589
- 終了ページ
- 1592
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1097/WNR.0b013e328312181c
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
Altered glutamate signaling is associated with Parkinson's disease. To study the involvement of the cystine/glutamate antiporter in the pathogenesis of Parkinson's disease, we developed new polyclonal antibodies recognizing xCT, the specific subunit of this antiporter. The striatal xCT protein expression level was investigated in a hemi-Parkinson rat model, using semiquantitative western blotting. We observed time-dependent changes after a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway with increased expression levels in the deafferented striatum after 3 weeks. Twelve weeks postlesion, expression levels returned to normal. These data suggest, for the first time, an involvement of the cystine/glutamate antiporter in determining the aberrant glutamate neurotransmission in the striatum of a parkinsonian brain. NeuroReport 19:1589--1592 (C) Wolters Kluwer Health | Lippincott Williams & Wilkins.
- リンク情報
- ID情報
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- DOI : 10.1097/WNR.0b013e328312181c
- ISSN : 0959-4965
- Web of Science ID : WOS:000260438100007