高橋雄 (Yu Takahashi) - マイポータル

基本情報

所属: 厚生労働省国立医薬品食品衛生研究所毒性部室長

学位: 博士（理学）(東京大学大学院)

J-GLOBAL ID: 200901020332137440
researchmap会員ID: 5000066942

研究分野

ライフサイエンス / 発生生物学 /

学歴

- 1991年

東京大学大学院, 理学系研究科, 動物学専攻
- 1991年

University of Tokyo, Graduate school of Science, Department of Zoology

論文

Diverse unintended on-target mutations induced by zygote genome-editing using CRISPR/Cas9 system

Toshime Igarashi, Yukuto Yasuhiko, Ryuichi Ono, Erika Tachihara, Miki Uchiyama, Atsuya Takagi, Yu Takahashi, Makiko Kuwagata, Satoshi Kitajima

Fundamental Toxicological Sciences 8(5) 161-167 2021年10月査読有り
Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo.

Takahashi Y, Yasuhiko Y, Takahashi J, Takada S, Johnson RL, Saga Y, Kanno J

Developmental biology 380 172-184 2013年8月査読有り
The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.

Development. 2010年
Mesp-family genes are required for segmental patterning and segmental border formation

Yumiko Saga, Yu Takahashi

SOMITOGENESIS 638 113-123 2008年査読有り
Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm (PSM) specific enhancer of Mesp.

Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, Saga Y

Development 135 3511-3519 2008年査読有り
Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation.

Takahashi Y, Takagi A, Hiraoka S, Koseki H, Kanno J, Rawls A, Saga Y

Dev Dyn 236 1484-1494 2007年査読有り
Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.

Takahashi ,Y, Yasuhiko ,Y, Kitajima ,S, Kannno, J, Saga ,Y

Dev. Biol. 304 593-603 2007年査読有り
Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2.

Nakajima Y, Morimoto M, Takahashi Y, Koseki H, Saga Y

Development (Cambridge, England) 133(13) 2517-2525 2006年7月査読有り
Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression.

Yasuhiko, Y, Haraguchi, S, Kitajima, S, Takahashi, Y, Kanno, J, Saga ,Y

Proc.Natl.Acad.Sci.USA 103(103) 3651-3656 2006年査読有り
Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostrocaudal patterning of somites.

Takahashi, Y, Kitajima S, Inoue T, Kanno, J, Saga Y

Development 132 787-796 2005年査読有り
Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling.

Ishikawa A, Kitajima S, Takahashi Y, Kokubo H, Kanno J, Inoue T, Saga Y

Mech Dev 121 1443-53 2004年
Feedback loops comprising DII1, DII3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites

Y Takahashi, T Inoue, A Gossler, Y Saga

DEVELOPMENT 130(18) 4259-4268 2003年9月
The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesis

J Rhee, Y Takahashi, Y Saga, J Wilson-Rawls, A Rawls

DEVELOPMENTAL BIOLOGY 254(2) 248-261 2003年2月
Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis

A Nomura-Kitabayashi, Y Takahashi, S Kitajima, T Inoue, H Takeda, Y Saga

DEVELOPMENT 129(10) 2473-2481 2002年5月
Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method

O Ohara, T Nagase, G Mitsui, H Kohga, R Kikuno, S Hiraoka, Y Takahashi, S Kitajima, Y Saga, H Koseki

DNA RESEARCH 9(2) 47-57 2002年4月
Mesp2 initiates somite segmentation through the Notch signalling pathway

Y Takahashi, K Koizumi, A Takagi, S Kitajima, T Inoue, H Koseki, Y Saga

NATURE GENETICS 25(4) 390-396 2000年8月
Significant role of laminin-1 in branching morphogenesis of mouse salivary epithelium cultured in basement membrane matrix

Y Hosokawa, Y Takahashi, Y Kadoya, S Yamashina, M Nomizu, Y Yamada, H Nogawa

DEVELOPMENT GROWTH & DIFFERENTIATION 41(2) 207-216 1999年4月

MISC

Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites (vol 132, pg 787, 2005)

Yu Takahashi, Shuichi Hiraoka, Satoshi Kitajima, Tohru Inoue, Jun Kanno, Yumiko Saga

DEVELOPMENT 135(23) 3969-3969 2008年12月
A notch modulator Dll3 partially substitutes for roles of Mesp2 in rostro-caudal patterning of somites

Y. Takahashi, S. Kitajima, Y. Yasuhiko, J. Kanno, Y. Saga

MECHANISMS OF DEVELOPMENT 122 S151-S152 2005年9月
Genetic dissection of notch functions in rostrocaudal patterning of somites.

Y Takahashi, T Inoue, A Gossler, Y Saga

DEVELOPMENTAL BIOLOGY 259(2) 461-461 2003年7月
SUBSTITUTION FOR MESENCHYME BY BASEMENT-MEMBRANE-LIKE SUBSTRATUM AND EPIDERMAL GROWTH-FACTOR IN INDUCING BRANCHING MORPHOGENESIS OF MOUSE SALIVARY EPITHELIUM

H NOGAWA, Y TAKAHASHI

DEVELOPMENT 112(3) 855-861 1991年7月

所属学協会

2021年4月 - 現在

日本動物学会
日本分子生物学会
日本発生生物学会
The Molecular Biology Society of Japan
The Japanese Society of Developmental Biologists

高橋雄

基本情報

研究分野

学歴

論文

MISC

所属学協会

メニュー

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