論文

査読有り
2007年2月1日

Experimental regeneration of canine larynx: A trial with tissue engineering techniques

Acta Oto-Laryngologica
  • Masaru Yamashita
  • ,
  • Koichi Omori
  • ,
  • Shin Ichi Kanemaru
  • ,
  • Akhmar Magrufov
  • ,
  • Yoshihiro Tamura
  • ,
  • Hiroo Umeda
  • ,
  • Masanao Kishimoto
  • ,
  • Tatsuo Nakamura
  • ,
  • Juichi Ito

127
SUPPL. 557
開始ページ
66
終了ページ
72
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/00016480601068014
出版者・発行元
TAYLOR & FRANCIS AS

Conclusion: Since this tissue engineering technique is cost-effective and is less invasive to patients, it may replace conventional approaches in laryngeal reconstructive surgeries. Objective: Laryngeal cancer is one of the most prevalent cancers in the head and neck region, and frequently requires surgical resection. Although there are many ways to reconstruct the larynx after resection, donor tissue is usually required. Recently, tissue engineering techniques have become widely accepted in clinical medicine and have already been applied to some organs. This animal experiment was designed to elucidate the efficacy of laryngeal regeneration using tissue engineering technique. Materials and methods: A bioartificial scaffold was designed from a replica of a canine larynx. A dental cast was used to replicate the intricate inside shape of the larynx. After copying its shape on a polypropylene mesh sheet, this sheet was coated with spongy collagen from porcine skin. A hemilaryngectomy was performed on beagle dogs under general anesthesia. Then the scaffold, preclotted with a mixture of peripheral blood and bone marrow-derived stromal cells, was implanted and fixed. The postoperative status was examined fiberscopically. Results: On the eighth day after the operation, the surface of the implant was covered with soft tissue. Finally, the implant was completely covered with regenerated mucosa. © 2007 Taylor & Francis.

リンク情報
DOI
https://doi.org/10.1080/00016480601068014
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17453449
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000244923100018&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33947313976&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33947313976&origin=inward
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33947313976&origin=inward
ID情報
  • DOI : 10.1080/00016480601068014
  • ISSN : 0001-6489
  • eISSN : 1651-2553
  • PubMed ID : 17453449
  • SCOPUS ID : 33947313976
  • Web of Science ID : WOS:000244923100018

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