Shigeo Koido

Profile Information

Affiliation: Jikei University

Degree: (BLANK)(Jikei University)

J-GLOBAL ID: 200901051478255812
researchmap Member ID: 5000067989

Research Interests

Research Areas

Research History

1987

Faculty of Medicine, Jikei University

Education

2002 - Present

東京慈恵会医科大学附属柏病院消化器・肝臓内科
1998 - 2002

Dept. of Adult Oncology, Harvard Medical School, Dana-Farber Cancer Institute.
- 1993

Jikei University
1993

Jikei University
- 1987

Jikei University
1987

School of Medicine, Faculty of Medicine, Jikei University

Awards

Papers

180

Dendritic cell vaccination in combination with erlotinib in a patient with inoperable lung adenocarcinoma: a case report.

Takuya Kosumi, Masanori Kobayashi, Shigetaka Shimodaira, Haruo Sugiyama, Shigeo Koido

Journal of medical case reports, 18(1) 88-88, Feb 10, 2024 Peer-reviewedLast author
Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease.

Shizuka Suzuki, Kan Uchiyama, Yutaro Motoi, Yuuki Yoshii, Yukari Inoue, Takahiro Kubota, Shunichi Odahara, Yuichiro Ohtaki, Shinichiro Takami, Zensho Ito …

BMC gastroenterology, 23(1) 239-239, Jul 15, 2023 Peer-reviewed
Impact of Bifidobacterium adolescentis in patients with abdominal aortic aneurysm: a cross-sectional study.

Eisaku Ito, Takao Ohki, Naoki Toya, Hikaru Nakagawa, Ayako Horigome, Toshitaka Odamaki, Jin-Zhong Xiao, Shigeo Koido, Yuriko Nishikawa, Toshifumi Ohkusa …

Bioscience of microbiota, food and health, 42(1) 81-86, 2023 Peer-reviewed
Clinical features, therapeutic outcomes and recovery period of long COVID.

Kazuki Takakura, Machi Suka, Mikio Kajihara, Shigeo Koido

Journal of medical virology, 95(1) e28316, Nov 22, 2022 Peer-reviewedLast author
Dysbiosis of the Fecal and Biliary Microbiota in Biliary Tract Cancer.

Zensho Ito, Shigeo Koido, Kumiko Kato, Toshitaka Odamaki, Sankichi Horiuchi, Takafumi Akasu, Masayuki Saruta, Taigo Hata, Yu Kumagai, Shuichi Fujioka …

Cancers, 14(21), Oct 31, 2022 Peer-reviewed
The Detection of Immunity against WT1 and SMAD4P130L of EpCAM+ Cancer Cells in Malignant Pleural Effusion.

Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato Jr, Sohsuke Yamada, Haruo Sugiyama …

International journal of molecular sciences, 23(20), Oct 12, 2022 Peer-reviewed
Usefulness of Bifidobacterium longum BB536 in Elderly Individuals with Chronic Constipation: A Randomized Controlled Trial.

Tsutomu Takeda, Daisuke Asaoka, Shuko Nojiri, Naotake Yanagisawa, Yuji Nishizaki, Taro Osada, Shigeo Koido, Akihito Nagahara, Noriko Katsumata, Toshitaka Odamaki …

The American journal of gastroenterology, 118(3) 561-568, Oct 3, 2022 Peer-reviewed
The insoluble excretion of multi-matrix system mesalazine preparations in patients with ulcerative colitis

Ohtaki Yuichiro, Uchiyama Kan, Kamiya Hirotaka, Moriizumi Eri, Yamada Moe, Aoki Yuma, Watanabe Toshimune, Kiryu Sachie, Suzuki Sizuka, Matsumoto Yoshihiro …

BMC Gastroenterology, 22(1) 390-390, Aug 18, 2022 Peer-reviewed
The stimulatory effect of fusobacteria on dendritic cells under aerobic or anaerobic conditions.

Shigeo Koido, Sankichi Horiuchi, Shin Kan, Tsuuse Bito, Zensho Ito, Kan Uchiyama, Masayuki Saruta, Nobuhiro Sato, Toshifumi Ohkusa

Scientific reports, 12(1) 10698-10698, Jun 23, 2022 Peer-reviewedLead authorCorresponding author
Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial.

Daisuke Asaoka, Jinzhong Xiao, Tsutomu Takeda, Naotake Yanagisawa, Takahiro Yamazaki, Yoichiro Matsubara, Hideki Sugiyama, Noemi Endo, Motoyuki Higa, Koji Kasanuki …

Journal of Alzheimer's disease : JAD, May 7, 2022 Peer-reviewed
マイクロバイオーム解析による消化器疾患の病態解明と応用胆道がんにおける糞便および、胆汁細菌叢のディスバイオシス

伊藤善翔, 小井戸薫雄, 大草敏史

日本消化器病学会雑誌, 119(臨増総会) A166-A166, Mar, 2022
Growth of various obligate and facultative anaerobic intestinal bacteria in cell culture medium under aerobic and anaerobic culture conditions

Toshifumi OHKUSA, Shigeo KOIDO, Sankichi HORIUCHI, Shin KAN, Zensho ITO, Yuriko NISHIKAWA, Nobuhiro SATO

Bioscience of Microbiota, Food and Health, 41(3) 145-148, 2022 Peer-reviewed
Impact of qualitative endoscopic ultrasonography on fatty pancreas at a referral medical center.

Atsushi Kawamura, Kazuki Takakura, Yuichi Torisu, Yuji Kinoshita, Yoichi Tomita, Masanori Nakano, Takashi Yamauchi, Machi Suka, Kazuki Sumiyama, Shigeo Koido …

JGH open : an open access journal of gastroenterology and hepatology, 6(1) 44-49, Jan, 2022 Peer-reviewed
Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma.

Sachie Kiryu, Zensho Ito, Machi Suka, Tsuuse Bito, Shin Kan, Kan Uchiyama, Masayuki Saruta, Taigo Hata, Yuki Takano, Shuichi Fujioka …

BMC cancer, 21(1) 1197-1197, Nov 10, 2021 Peer-reviewedLast authorCorresponding author
Pancreatic tuberculosis in an immunocompetent young female mimicking a malignant tumor: A case report and diagnostic radiological investigation.

Tomomi Miyamoto, Kazuya Tone, Shunsuke Inaki, Ryo Saito, Miku Maeda, Yuko Nagano, Takuya Akutsu, Atsuki Furube, Mina Gochi, Kenji Motohashi …

Clinical imaging, 81 114-117, Oct 12, 2021 Peer-reviewed
転移性肝腫瘍から肝不全を来した十二指腸癌の1例

戸田明世, 伊藤善翔, 石川将史, 桐生幸苗, 中田正裕, 大瀧雄一朗, 鈴木静香, 松本喜弘, 小井戸薫雄, 猿田雅之

日本内科学会関東地方会, 668回 34-34, May, 2021
胆道がんにおける腸内、胆汁細菌叢のディスバイオシス

伊藤善翔, 小井戸薫雄, 加藤久美子, 小田巻俊孝, 清水金忠, 西川百合子, 佐藤信紘, 大草敏史

腸内細菌学雑誌, 35(2) 113-113, Apr, 2021
【腸内細菌とがんとの関連、その最新情報】膵疾患と腸内細菌

伊藤善翔, 小井戸薫雄, 大草敏史

腸内細菌学雑誌, 35(1) 13-18, Jan, 2021
消化管疾患とマイクロバイオームのクロストーク胆道がんにおける腸内、口腔、胆汁細菌叢のディスバイオシス

伊藤善翔, 小井戸薫雄, 加藤久美子, 小田巻俊孝, 清水金忠, 西川百合子, 佐藤信紘, 大草敏史

日本消化管学会雑誌, 5(Suppl.) 175-175, Jan, 2021
Long-term outcomes of antibiotic combination therapy for ulcerative colitis.

Yuriko Nishikawa, Nobuhiro Sato, Shintaro Tsukinaga, Kan Uchiyama, Shigeo Koido, Dai Ishikawa, Toshifumi Ohkusa

Therapeutic advances in chronic disease, 12 20406223211028790-20406223211028790, 2021 Peer-reviewed

Misc.

439

腸内細菌と樹状細胞—Intestinal Bacteria and Dendritic Cells—特集腸内細菌と免疫,その最新情報

小井戸薫雄, 伊藤善翔, 闞鑫, 尾藤通世, 堀内三吉, 内山幹, 大草敏史

腸内細菌学雑誌 = Journal of intestinal microbiology, 36(3) 135-141, Jul, 2022
マイクロバイオーム解析による消化器疾患の病態解明と応用胆道がんにおける糞便および、胆汁細菌叢のディスバイオシス

伊藤善翔, 小井戸薫雄, 大草敏史

日本消化器病学会雑誌, 119(臨増総会) A166-A166, Mar, 2022
Intestinal Bacteria and Dendritic Cells

小井戸薫雄, 伊藤善翔, Kan Shin, 尾藤通世, 堀内三吉, 内山幹, 大草敏史

腸内細菌学雑誌, 36(3), 2022
Bifidobacterium breve MCC1274 improves cognitive function in patients with mild cognitive impairment (MCI): Part 1: Results of cognitive function and imaging analysis

浅岡大介, 清水金忠, 清水金忠, 竹田努, 小井戸薫雄, 大野和也, 勝又紀子, 勝又紀子, 永原章仁, 大草敏史 …

腸内細菌学雑誌, 36(2), 2022
Investigation of relationship between clinical symptoms and gut microbiota composition in older patients with chronic constipation and the therapeutic effect of Bifidobacterium longum BB536

竹田努, 浅岡大介, 長田太郎, 野尻宗子, 柳澤尚武, 西崎祐史, 小井戸薫雄, 永原章仁, 勝又紀子, 勝又紀子 …

腸内細菌学雑誌, 36(2), 2022
Bifidobacterium breve MCC1274 improves cognitive function in patients with mild cognitive impairment (MCI): Part 2: Results of gut microbiota analysis

大野和也, 浅岡大介, 竹田努, 小井戸薫雄, 勝又紀子, 勝又紀子, 小田巻俊孝, 小田巻俊孝, 清水金忠, 清水金忠 …

腸内細菌学雑誌, 36(2), 2022
胆道がんにおける糞便および,胆汁細菌叢のディスバイオシス

伊藤善翔, 小井戸薫雄, 大草敏史, 大草敏史

日本消化器病学会雑誌(Web), 119, 2022
高齢者の慢性便秘症患者を対象とした便通異常改善効果に対するBifidobacterium longum BB536のランダム化二重盲検プラセボ対照並行群間比較試験

竹田努, 浅岡大介, 長田太郎, 野尻宗子, 柳澤尚武, 西崎祐史, 小井戸薫雄, 永原章仁, 小田巻俊孝, 清水金忠 …

日本消化器病学会雑誌, 118(臨増大会) A689-A689, Oct, 2021
腸管IgA反応性およびIgA結合菌の変化はIPMNの悪性進展を示唆する

對田尚, 宮内栄治, 伊藤善翔, 内山幹, 小井戸薫雄, 荒川廣志, 大草敏史, 大野博司

日本消化器病学会雑誌, 118(臨増大会) A743-A743, Oct, 2021
転移性肝腫瘍から肝不全を来した十二指腸癌の1例

戸田明世, 伊藤善翔, 石川将史, 桐生幸苗, 中田正裕, 大瀧雄一朗, 鈴木静香, 松本喜弘, 小井戸薫雄, 猿田雅之

日本内科学会関東地方会, 668回 34-34, May, 2021
胆道がんにおける腸内、胆汁細菌叢のディスバイオシス

伊藤善翔, 小井戸薫雄, 加藤久美子, 小田巻俊孝, 清水金忠, 西川百合子, 佐藤信紘, 大草敏史

腸内細菌学雑誌, 35(2) 113-113, Apr, 2021
Relationship between abdominal aortic aneurysm and intestinal microbiota-research for pathogenic bacteria of aortic aneurysm-

伊藤栄作, 大木隆生, 戸谷直樹, 中川光, 秋葉直志, 堀米綾子, 小田巻俊孝, 小田巻俊孝, 清水金忠, 清水金忠 …

腸内細菌学雑誌, 35(2), 2021
Disbiosis of intestinal, oral and bile flora in chorangiocarcinoma

伊藤善翔, 小井戸薫雄, 加藤久美子, 小田巻俊孝, 小田巻俊孝, 清水金忠, 清水金忠, 西川百合子, 佐藤信紘, 大草敏史 …

日本消化管学会雑誌, 5(Supplement), 2021
腸管IgA反応性およびIgA結合菌の変化はIPMNの悪性進展を示唆する

對田尚, 對田尚, 宮内栄治, 伊藤善翔, 内山幹, 小井戸薫雄, 荒川廣志, 大草敏史, 大草敏史, 大野博司 …

日本消化器病学会雑誌(Web), 118, 2021
高齢者の慢性便秘症患者を対象とした便通異常改善効果に対するBifidobacterium longum BB536のランダム化二重盲検プラセボ対照並行群間比較試験

竹田努, 浅岡大介, 長田太郎, 野尻宗子, 柳澤尚武, 西崎祐史, 小井戸薫雄, 永原章仁, 小田巻俊孝, 清水金忠 …

日本消化器病学会雑誌(Web), 118, 2021
潰瘍性大腸炎患者におけるpH依存型メサラジン製剤不溶排泄の実態調査

大瀧雄一朗, 杉山悦郎, 鈴木静香, 星野優, 伊藤善翔, 内山幹, 小井戸薫雄, 猿田雅之

日本消化器病学会雑誌, 117(臨増大会) A705-A705, Oct, 2020
3.消化器疾患に関する腸内細菌叢の関与

小井戸薫雄

日本臨床腸内微生物学会誌, 22(1) 7-9, 2020
Splenic flexure syndrome (Payr disease)

小井戸薫雄

日本臨床, 2020
潰瘍性大腸炎患者におけるpH依存型メサラジン製剤不溶排泄の実態調査

大瀧雄一朗, 杉山悦郎, 鈴木静香, 星野優, 伊藤善翔, 内山幹, 小井戸薫雄, 猿田雅之

日本消化器病学会雑誌(Web), 117, 2020
胃良悪性境界病変併存多発胃過形成ポリープに対するH.pylori除菌療法後に急速に発育する進行胃癌を認めた1例

山本純平, 荒井千香子, 竹村大輝, 番大和, 小山誠太, 安達世, 荒川廣志, 赤須貴文, 星野優, 伊藤善翔 …

Progress of Digestive Endoscopy, 96(Suppl.) s116-s116, Dec, 2019

Books and Other Publications

新・医用放射線科学講座診療画像機器学第2版

荒川哲, 石蔵文信, 市川勝弘, 稲本一夫, 上原真澄, 遠藤哲朗, 川又雅次, 小井戸薫雄, 五味勉, 小栁慶二, 佐藤直高, 鈴木克己, 鈴木英幹, 高橋哲彦, 高橋康幸, 田島廣之, 田中秀明, 田中利恵, 堂本拓哉, 中村正, 根岸徹, 橋本憲幸, 馬場理香, 平間信, 細羽実, 松本政雄, 宮地利明, 村瀬研也, 山岸順一, 山﨑達也, 岡部哲夫, 小倉敏裕, 石田隆行 (Role: Joint author)

医歯薬出版, Jan 25, 2017 (ISBN: 4263206479)

Presentations

血中ウイルス抗原陰性生検組織陽性のサイトメガロウイルス感染合併潰瘍性大腸炎の臨床病理学的特徴

第95回日本消化器病学会, 2009
チオプリン製剤不耐の日本人炎症性腸疾患患者におけるThiopurine-5-methyltransferaseおよびInosine triphospatase pyrophosphohydrase遺伝子の検討

第95回日本消化器病学会, 2009
肝血管肉腫に対する抗腫瘍免疫の誘導

第95回日本消化器病学会, 2009
トール様受容体を刺激した樹状細胞と熱処理した大腸癌細胞の融合細胞は効果的な細胞傷害性T細胞を誘導する

第95回日本消化器病学会, 2009
膵臓癌に対する塩酸ゲムシタビンとWT1ペプチドワクチン併用療法の有効性

日本消化器内視鏡学会, 2009
肝癌細胞に発現するチトクロームP450分子の抗腫瘍免疫誘導における意義

第45回肝臓病学会, 2009
肝血管肉腫に対する抗腫瘍免疫の誘導

第45回肝臓病学会, 2009
Assessment of telomerase inactivation in T cell responses and antitumor immunity

The 96th annual meeting of The American association of immunologists, 2009
Adverse reactions of azathioprine/6-mercaptopurine treatment, thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease.

Digestive Disease Week 2009, 2009
Fusions of human dendritic cells and hepatocellular carcinoma cells induce cytotoxic and regulatory T cells in vitro.

Keystone Symposia, 2009
Fusions of human dendritic cells and pancreatic carcinoma cells induce antigen-specific antitumor immune responses.

Digestive Disease Week 2009, 2009
Dendritic cells engineered to secrete interleukin-12 delivered into sarcoma results in the cross-priming of CD8+ T cells response against hemoglobin-beta.

第12回日本がん免疫学会総会, 2008
アロ癌細胞株と自己樹状細胞との融合細胞にて誘導されたMUC1特異的細胞障害性Ｔ細胞の特徴

第94会日本消化器病学会総会, 2008
樹状細胞と肝細胞癌との融合細胞ワクチンによる免疫応答の誘導

第50回日本消化器病学会大会 JDDW, 2008
DC.IL-12 therapy elicits protective immunity against the tumor-associated vasculature.

第67回日本癌学会学術総会, 2008
Establishment of many types of primary cancer cell lines; Colon, pancreas, melanoma, and metastatic brain tumors.

第67回日本癌学会学術総会, 2008
Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells.

第67回日本癌学会学術総会, 2008
DCワクチンと5-FU併用のNK細胞を介する抗腫瘍増強効果

第２１回日本バイオセラピィ学会, 2008
固形腫瘍拒絶抗原としてのHemoglobin-βの効果

第２１回日本バイオセラピィ学会, 2008
OK-432は樹状細胞と大腸癌細胞の融合細胞の融合効率を増強し,自己大腸癌に対する効果的CTLを誘導する.

第93会日本消化器病学会総会, 2007

Professional Memberships

Research Projects

進行膵癌における腫瘍免疫微小環境の再構築を目指した複合的免疫化学療法の開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

小井戸薫雄, 村橋睦了
RNA vaccine that exerts antitumor effect via non-canonical antigen presentation pathway

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

ITO MASAKI
Development of combined immunochemotherapy based on personalized immunological analysis in the pancreatic tumor microenvironments

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Koido Shigeo
膵癌微少環境における個別化免疫解析に基づく複合的免疫化学療法の開発

文部科学省科学研究費基盤研究 (C), Apr, 2019 - Mar, 2022

小井戸薫雄
膵臓がん標準化学療法の治療効果を規定する腸内細菌叢の同定

科学研究費助成事業奨励研究, 奨励研究, 日本学術振興会, 2019 - 2019

闞鑫, 小井戸薫雄
Selection of immunochemotherapy for patients with advanced pancreatic cancer

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Koido Shigeo
Development of cancer vaccine using adjuvant function encrypted artificial antigens

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Masaki Ito, SHIBA KIYOTAKA
Quantitative anlysis on antigenic peptides from the tumor antigen and its application to a biomarker for cancer immunotherapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

HOMMA SADAMU, IWAMOTO Takeo, KOIDO Shigeo
Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

KOIDO Shigeo, HOMMA Sadamu
Development of a novel cancer immunotherapy using the artificial proteins consisted in the functional peptide motifs.

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2011

ITO Masaki, HOMMA Sadamu, KOIDO Shigeo, SHIBA Kiyotaka
Immunotherapy targeting tumor vascular cells using iPS cell-derived vaccine

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2011

HOMMA Sadamu, KOIDO Shigeo, ITO Masaki
Studies on generation of peptide vaccine against cancer stem cells of pancreatic cancer using proteomic analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

HOMMA Sadamu
Mucosa-associated bacteria in ulcerative colitis before and after new antibiotic combination therapy : DNA polymorphism analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

OHKUSA Toshifumi, KOIDO Shigeo, ODAHARA Shunichi, KOMITA HIDEO
Mucosa-associated bacteria in ulcerative colitis before and after new antibiotic combination therapy : DNA polymorphism analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

OHKUSA Toshifumi, KOIDO Shigeo, ODAHARA Shunichi, KOMITA HIDEO
Induction of antitumor immunity by fusions of dendritic cells and pancreatic cancer stem cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

KOIDO Shigeo, HONMA Sadamu
A novel vaccines based on dendritic/tumor fusion cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2005

KOIDO Shigeo
Fusions of Cancer and Dendritic Cells as a novel Cancer vaccine

Grant-in-Aid for Scientific Research, 2000
大腸癌の他臓器転移における新しい腫瘍マーカー

科学研究費助成事業奨励研究(A), 奨励研究(A), 日本学術振興会, 1997 - 1998

小井戸薫雄
大腸癌の他臓器転移における新しい腫瘍マーカー

科学研究費助成事業, 奨励研究(A), 文部科学省科学研究費奨励研究 (A), 1997 - 1998

小井戸薫雄
アジュバント機能が包含された人工タンパク質抗原を用いたがんワクチンの開発

文部科学省科学研究費基盤研究 (C)

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